ONTOLOGY REPORT - ANNOTATIONS


Term:multiple myeloma
go back to main search page
Accession:DOID:9538 term browser browse the term
Definition:A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Synonyms:exact_synonym: Kahler Disease;   Multiple Myelomas;   Myeloma-Multiples;   Myelomatoses;   Myelomatosis;   Plasma Cell Myeloma;   Plasma Cell Myelomas
 narrow_synonym: AL;   AL AMYLOIDOSIS;   AMYLOIDOSIS, SYSTEMIC;   Multiple Myeloma, Translocation 11,14 Type
 related_synonym: Multiple Myeloma, Resistance To;   Multiple Myeloma, t(11;14) Type, Susceptibility To
 primary_id: MESH:D009101;   RDO:0005994
 alt_id: OMIM:254500
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants       view all columns           Sort by:
 
multiple myeloma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:11081075
RGD:11081144
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:11038914
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:11035276
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:11040544
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:8554872
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:11554173
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:11353847
RGD:11554173
G Bcl2l10 BCL2 like 10 JBrowse link 8 82,288,705 82,294,750 RGD:14392808
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:11554173
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:8554872
G Btg1 BTG anti-proliferation factor 1 JBrowse link 7 37,812,831 37,815,088 RGD:11554173
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:11038794
G Cbx7 chromobox 7 JBrowse link 7 121,136,067 121,153,503 RGD:11352716
RGD:11554173
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:11554173
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:1581171
RGD:8554872
RGD:11554173
RGD:11353784
RGD:7240710
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:1581171
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:1581171
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:11522720
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:11352240
RGD:11352268
RGD:11352251
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:11352814
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:11354971
RGD:11554173
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:8554872
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:11252185
RGD:11554173
G Cfhr1 complement factor H-related 1 JBrowse link 13 56,862,666 56,877,650 RGD:11040544
G Chi3l1 chitinase 3 like 1 JBrowse link 13 51,022,844 51,030,797 RGD:4892645
G Crbn cereblon JBrowse link 4 138,864,910 138,885,786 RGD:11554173
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:11554173
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:11554173
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:11352247
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:11352726
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:11352748
RGD:11352804
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:11352804
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:11041181
G Ephx1 epoxide hydrolase 1 JBrowse link 13 99,271,390 99,300,580 RGD:11252116
RGD:11554173
RGD:11252122
RGD:11252121
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:10450871
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:11252199
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:11049149
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:11040778
RGD:11040938
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:11554173
RGD:8554872
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:11040544
G Flt3lg fms-related tyrosine kinase 3 ligand JBrowse link 1 101,126,006 101,131,413 RGD:11075232
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:11352777
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:10450826
RGD:10450846
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:10755413
RGD:11075094
RGD:10755419
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:10450846
RGD:11554173
RGD:10450847
G Hfe homeostatic iron regulator JBrowse link 17 43,661,276 43,669,327 RGD:8694350
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:11353882
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:8554872
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:11554173
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:11354981
RGD:11520780
G Idh1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic JBrowse link 9 71,882,108 71,911,645 RGD:8554872
G Idh2 isocitrate dehydrogenase (NADP(+)) 2, mitochondrial JBrowse link 1 141,874,354 141,893,674 RGD:8554872
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:11041888
RGD:11049458
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:11049156
RGD:11059513
RGD:11051973
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:11051973
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:11051973
RGD:11522764
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:11040938
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:11554173
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:11526161
RGD:11554173
RGD:11530055
RGD:11530019
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:1581756
RGD:8554872
G Lig4 DNA ligase 4 JBrowse link 16 85,331,771 85,339,496 RGD:1600305
RGD:8554872
RGD:7240710
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:11554173
G Lrrc56 leucine rich repeat containing 56 JBrowse link 1 214,182,232 214,197,184 RGD:8554872
G Maf MAF bZIP transcription factor JBrowse link 19 48,179,826 48,200,995 RGD:13592920
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:11554173
G Mefv MEFV innate immuity regulator, pyrin JBrowse link 10 12,045,813 12,056,229 RGD:11531123
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:2317526
G Mir19a microRNA 19a JBrowse link 15 100,180,162 100,180,243 RGD:11554173
G Mir92a1 microRNA 92a-1 JBrowse link 15 100,180,586 100,180,663 RGD:11554173
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:10449397
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:11075095
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase JBrowse link 1 37,743,089 37,774,485 RGD:11075095
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:11554173
G Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:8554872
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:2298898
RGD:2298895
G Notch2 notch receptor 2 JBrowse link 2 200,187,184 200,320,403 RGD:1580763
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:10769348
RGD:11554173
RGD:10755419
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:11535049
RGD:8554872
G Nuak1 NUAK family kinase 1 JBrowse link 7 25,039,336 25,111,118 RGD:11554173
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:11554173
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:8554872
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:11552578
RGD:10450846
RGD:11040544
G Prame preferentially expressed antigen in melanoma JBrowse link X 106,082,984 106,091,256 RGD:11535030
RGD:11554173
G Psors1c2 psoriasis susceptibility 1 candidate 2 JBrowse link 20 3,727,817 3,728,805 RGD:11554173
G Pthlh parathyroid hormone-like hormone JBrowse link 4 181,663,425 181,674,181 RGD:11554173
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:8554872
G Ranbp2 RAN binding protein 2 JBrowse link 20
20
28,027,054
28,365,538
28,076,664
28,375,676
RGD:9835349
G Runx1 runt-related transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:6482834
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:1581238
RGD:11554173
G Sparc secreted protein acidic and cysteine rich JBrowse link 10 40,742,390 40,764,232 RGD:11554173
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581367
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:11038665
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:11062101
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11073605
RGD:11073614
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:10449450
RGD:10449453
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:11038719
G Tnfrsf13b TNF receptor superfamily member 13B JBrowse link 10 47,399,834 47,422,907 RGD:11554173
G Tnfrsf17 TNF receptor superfamily member 17 JBrowse link 10 4,252,097 4,258,335 RGD:2317306
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:11073716
RGD:8554872
RGD:11075073
RGD:11073728
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:11075094
RGD:11075095
G Ulk4 unc-51 like kinase 4 JBrowse link 8 129,631,003 129,919,080 RGD:11554173
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:11079182
G Xpo5 exportin 5 JBrowse link 9 17,125,201 17,163,170 RGD:11041735
G Xrcc4 X-ray repair cross complementing 4 JBrowse link 2 18,674,496 18,927,463 RGD:8698655
G Xrcc5 X-ray repair cross complementing 5 JBrowse link 9 79,659,275 79,748,050 RGD:8698655
plasmacytic leukemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:5490532
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:11038665

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14919
    syndrome 4713
      primary immunodeficiency disease 935
        lymphoproliferative syndrome 594
          multiple myeloma 105
            indolent myeloma 0
            non-secretory myeloma 0
            osteosclerotic myeloma 0
            plasmacytic leukemia 2
            refractory plasma cell neoplasm 0
            smoldering myeloma 0
Path 2
Term Annotations click to browse term
  disease 14919
    disease of anatomical entity 14083
      Immune & Inflammatory Diseases 3002
        immune system disease 2424
          Immunoproliferative Disorders 599
            lymphoproliferative syndrome 594
              lymphoma 337
                non-Hodgkin lymphoma 289
                  B-cell lymphoma 219
                    mature B-cell neoplasm 127
                      plasma cell neoplasm 110
                        multiple myeloma 105
                          indolent myeloma 0
                          non-secretory myeloma 0
                          osteosclerotic myeloma 0
                          plasmacytic leukemia 2
                          refractory plasma cell neoplasm 0
                          smoldering myeloma 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.