ONTOLOGY REPORT - ANNOTATIONS


Term:diabetic neuropathy
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Accession:DOID:9743 term browser browse the term
Definition:Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
Synonyms:exact_synonym: Asymmetric Diabetic Proximal Motor Neuropathy;   Diabetic Amyotrophies;   Diabetic Amyotrophy;   Diabetic Asymmetric Polyneuropathies;   Diabetic Asymmetric Polyneuropathy;   Diabetic Autonomic Neuropathies;   Diabetic Autonomic Neuropathy;   Diabetic Mononeuropathies;   Diabetic Mononeuropathy;   Diabetic Mononeuropathy Simplex;   Diabetic Mononeuropathy Simplices;   Diabetic Neuralgia;   Diabetic Neuralgias;   Painful Diabetic Neuropathies;   Painful Diabetic Neuropathy;   Symmetric Diabetic Proximal Motor Neuropathy;   diabetic neuropathies
 primary_id: MESH:D003929
 alt_id: RDO:0004047
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diabetic neuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra2b adrenoceptor alpha 2B JBrowse link 3 119,805,941 119,809,987 RGD:2313542
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:8695979
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:1626089
RGD:8548642
G Aldh2 aldehyde dehydrogenase 2 family member JBrowse link 12 40,466,418 40,498,813 RGD:2311150
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:5509623
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:10053667
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:5129222
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:4891134
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:11561957
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:2311441
RGD:11554173
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:11554173
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:8661787
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:2307060
G Cd63 Cd63 molecule JBrowse link 7 3,320,250 3,335,583 RGD:2314203
G Chrm2 cholinergic receptor, muscarinic 2 JBrowse link 4 64,089,028 64,091,090 RGD:11554173
G Cnr1 cannabinoid receptor 1 JBrowse link 5 49,307,584 49,333,064 RGD:2314631
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:2313898
G F7 coagulation factor VII JBrowse link 16 81,824,610 81,834,923 RGD:2312401
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:2315860
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:2315614
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:2313744
G Grm5 glutamate metabotropic receptor 5 JBrowse link 1 151,207,846 151,785,038 RGD:11554173
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:2313570
RGD:11554173
G Hhip Hedgehog-interacting protein JBrowse link 19 31,525,134 31,614,487 RGD:11552601
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:2311489
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:2306687
RGD:8549454
RGD:2313764
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:7401217
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2307344
RGD:11554173
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:11554173
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462056
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:2311567
G Mbp myelin basic protein JBrowse link 18 79,326,738 79,437,310 RGD:7327194
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:11554173
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:11554173
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:11554173
G Mpz myelin protein zero JBrowse link 13 89,524,204 89,530,070 RGD:9685782
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:5508379
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:5508379
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:2313218
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:10053667
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:11554173
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:5508379
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:5510012
RGD:5683915
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6483583
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:2311667
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:1642588
RGD:5508311
G Retn resistin JBrowse link 12 2,201,909 2,203,649 RGD:7207161
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:11554173
G Sord sorbitol dehydrogenase JBrowse link 3 114,176,127 114,207,368 RGD:1601362
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:2308808
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2302086
RGD:11554173
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:2302086
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:2302086
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:2312493
RGD:11554173
RGD:7777098
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:7401217
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 JBrowse link 5 3,783,247 3,836,485 RGD:10043378
G Ucp2 uncoupling protein 2 JBrowse link 1 165,506,375 165,512,744 RGD:2313516
G Ucp3 uncoupling protein 3 JBrowse link 1 165,482,912 165,495,895 RGD:2313516
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:2312761
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:11079183
Diabetic Foot term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:5686889
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:6767555
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6906887
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:7207269
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:8662463
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:8549356
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:2313575
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:8694068
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:8547813
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:2311669
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:7777174

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14875
    disease of anatomical entity 14051
      nervous system disease 9116
        peripheral nervous system disease 2009
          diabetic neuropathy 66
            Diabetic Foot 11
            Herrmann Syndrome 0
            diabetic autonomic neuropathy 0
            diabetic polyneuropathy 0
Path 2
Term Annotations click to browse term
  disease 14875
    Nutritional and Metabolic Diseases 4249
      disease of metabolism 4249
        acquired metabolic disease 2671
          carbohydrate metabolism disease 1739
            glucose metabolism disease 1739
              diabetes mellitus 1329
                Diabetes Complications 398
                  diabetic neuropathy 66
                    Diabetic Foot 11
                    Herrmann Syndrome 0
                    diabetic autonomic neuropathy 0
                    diabetic polyneuropathy 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.