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ONTOLOGY REPORT - ANNOTATIONS


Term:autophagosome assembly
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Accession:GO:0000045 term browser browse the term
Definition:The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
Synonyms:exact_synonym: autophagic vacuole assembly;   autophagosome biosynthesis;   autophagosome formation
 narrow_synonym: PAS formation
 related_synonym: autophagic vacuole formation


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autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ambra1 autophagy/beclin 1 regulator 1 JBrowse link 2 91,730,138 91,918,849 RGD:2290270
G Atg101 autophagy related 101 JBrowse link 15 101,284,301 101,290,947 RGD:2290270
G Atg12 autophagy related 12 JBrowse link 18 46,732,417 46,741,724 RGD:2290270
G Atg13 autophagy related 13 JBrowse link 2 91,674,612 91,710,597 RGD:2290270
G Atg14 autophagy related 14 JBrowse link 14 47,540,893 47,568,434 RGD:2290270
G Atg16l1 autophagy related 16-like 1 (S. cerevisiae) JBrowse link 1 87,756,007 87,792,428 RGD:2290270
G Atg16l2 autophagy related 16-like 2 (S. cerevisiae) JBrowse link 7 101,286,325 101,302,267 RGD:2290270
G Atg2a autophagy related 2A JBrowse link 19 6,241,478 6,262,304 RGD:2290270
G Atg2b autophagy related 2B JBrowse link 12 105,613,539 105,685,297 RGD:2290270
G Atg3 autophagy related 3 JBrowse link 16 45,158,829 45,188,538 RGD:2290270
G Atg4b autophagy related 4B, cysteine peptidase JBrowse link 1 93,754,905 93,789,606 RGD:2290270
G Atg5 autophagy related 5 JBrowse link 10 44,268,322 44,364,299 RGD:2290270
G Atg7 autophagy related 7 JBrowse link 6 114,643,097 114,860,614 RGD:2290270
G Atg9a autophagy related 9A JBrowse link 1 75,180,861 75,192,010 RGD:2290270
G Atg9b autophagy related 9B JBrowse link 5 24,384,181 24,392,143 RGD:2290270
G Bag3 BCL2-associated athanogene 3 JBrowse link 7 128,523,583 128,546,981 RGD:2290270
G Becn1 beclin 1, autophagy related JBrowse link 11 101,288,258 101,302,286 RGD:2290270
G Becn2 beclin 2 JBrowse link 1 175,920,329 175,922,225 RGD:2290270
G Ctsd cathepsin D JBrowse link 7 142,375,910 142,387,827 RGD:2290270
G Elapor1 endosome-lysosome associated apoptosis and autophagy regulator 1 JBrowse link 3 108,455,679 108,536,745 RGD:2290270
G Emc6 ER membrane protein complex subunit 6 JBrowse link 11 73,175,503 73,177,042 RGD:2290270
G Epm2a epilepsy, progressive myoclonic epilepsy, type 2 gene alpha JBrowse link 10 11,342,691 11,459,664 RGD:2290270
G Gabarap gamma-aminobutyric acid receptor associated protein JBrowse link 11 69,991,370 69,994,949 RGD:2290270
G Gabarapl1 gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 JBrowse link 6 129,533,192 129,542,331 RGD:2290270
G Gabarapl2 gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 JBrowse link 8 111,940,703 111,952,915 RGD:2290270
G Irgm1 immunity-related GTPase family M member 1 JBrowse link 11 48,865,245 48,871,420 RGD:2290270
G Irgm2 immunity-related GTPase family M member 2 JBrowse link 11 58,214,977 58,222,783 RGD:2290270
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 2 155,276,364 155,278,073 RGD:2290270
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 8 121,590,438 121,598,760 RGD:2290270
G Nsfl1c NSFL1 (p97) cofactor (p47) JBrowse link 2 151,494,182 151,511,310 RGD:2290270
G Pacs2 phosphofurin acidic cluster sorting protein 2 JBrowse link 12 113,014,454 113,074,401 RGD:2290270
G Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 JBrowse link 18 30,265,615 30,348,126 RGD:2290270
G Psen1 presenilin 1 JBrowse link 12 83,688,152 83,735,095 RGD:2290270
G Rab19 RAB19, member RAS oncogene family JBrowse link 6 39,380,709 39,390,666 RGD:2290270
G Rab1a RAB1A, member RAS oncogene family JBrowse link 11 20,201,412 20,226,856 RGD:2290270
G Rab1b RAB1B, member RAS oncogene family JBrowse link 19 5,099,207 5,106,996 RGD:2290270
G Rab23 RAB23, member RAS oncogene family JBrowse link 1 33,719,896 33,742,564 RGD:2290270
G Rab33b RAB33B, member RAS oncogene family JBrowse link 3 51,483,966 51,496,228 RGD:2290270
G Rab43 RAB43, member RAS oncogene family JBrowse link 6 87,788,853 87,812,164 RGD:2290270
G Rab7 RAB7, member RAS oncogene family JBrowse link 6 87,999,106 88,045,270 RGD:2290270
G Rb1cc1 RB1-inducible coiled-coil 1 JBrowse link 1 6,214,634 6,276,375 RGD:2290270
G Rufy4 RUN and FYVE domain containing 4 JBrowse link 1 74,124,433 74,148,230 RGD:2290270
G Sting1 stimulator of interferon response cGAMP interactor 1 JBrowse link 18 35,733,678 35,740,554 RGD:2290270
G Stx12 syntaxin 12 JBrowse link 4 132,854,064 132,884,458 RGD:2290270
G Synpo2 synaptopodin 2 JBrowse link 3 123,076,519 123,236,168 RGD:2290270
G Tmem41b transmembrane protein 41B JBrowse link 7 109,971,215 109,986,804 RGD:2290270
G Trappc8 trafficking protein particle complex 8 JBrowse link 18 20,817,211 20,896,425 RGD:2290270
G Trp53inp1 transformation related protein 53 inducible nuclear protein 1 JBrowse link 4 11,156,441 11,174,379 RGD:2290270
G Trp53inp2 transformation related protein 53 inducible nuclear protein 2 JBrowse link 2 155,381,811 155,389,847 RGD:2290270
G Ubqln1 ubiquilin 1 JBrowse link 13 58,176,156 58,215,653 RGD:2290270
G Ubqln2 ubiquilin 2 JBrowse link X 153,498,232 153,501,562 RGD:2290270
G Ubxn2a UBX domain protein 2A JBrowse link 12 4,876,979 4,907,716 RGD:2290270
G Ubxn2b UBX domain protein 2B JBrowse link 4 6,191,105 6,219,788 RGD:2290270
G Ulk1 unc-51 like kinase 1 JBrowse link 5 110,784,489 110,810,120 RGD:2290270
G Vmp1 vacuole membrane protein 1 JBrowse link 11 86,583,854 86,684,000 RGD:2290270
G Wdr45 WD repeat domain 45 JBrowse link X 7,721,987 7,728,201 RGD:2290270
G Wdr45b WD repeat domain 45B JBrowse link 11 121,327,203 121,354,447 RGD:2290270
G Wipi1 WD repeat domain, phosphoinositide interacting 1 JBrowse link 11 109,573,521 109,611,389 RGD:2290270
G Wipi2 WD repeat domain, phosphoinositide interacting 2 JBrowse link 5 142,629,533 142,669,672 RGD:2290270
engulfment of target by autophagosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 5 144,876,495 144,965,899 RGD:2290270
negative regulation of autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Becn1 beclin 1, autophagy related JBrowse link 11 101,288,258 101,302,286 RGD:2290270
G Chmp4b charged multivesicular body protein 4B JBrowse link 2 154,657,026 154,694,783 RGD:2290270
G Ehmt2 euchromatic histone lysine N-methyltransferase 2 JBrowse link 17 34,898,463 34,914,073 RGD:2290270
G Fez1 fasciculation and elongation protein zeta 1 (zygin I) JBrowse link 9 36,821,398 36,878,926 RGD:2290270
G Fez2 fasciculation and elongation protein zeta 2 (zygin II) JBrowse link 17 78,369,212 78,418,152 RGD:2290270
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 15 91,672,791 91,816,124 RGD:2290270
G Mtm1 X-linked myotubular myopathy gene 1 JBrowse link X 71,210,767 71,315,413 RGD:2290270
G Nupr1 nuclear protein transcription regulator 1 JBrowse link 7 126,623,246 126,625,470 RGD:2290270
G Phf23 PHD finger protein 23 JBrowse link 11 69,995,766 70,000,011 RGD:2290270
G Pink1 PTEN induced putative kinase 1 JBrowse link 4 138,313,409 138,326,296 RGD:2290270
G Scfd1 Sec1 family domain containing 1 JBrowse link 12 51,377,513 51,450,104 RGD:2290270
G Sec22b SEC22 homolog B, vesicle trafficking protein JBrowse link 3 97,901,227 97,922,318 RGD:2290270
G Smcr8 Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) JBrowse link 11 60,777,525 60,788,287 RGD:2290270
G Tmem39a transmembrane protein 39a JBrowse link 16 38,558,698 38,592,162 RGD:2290270
positive regulation of autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Becn1 beclin 1, autophagy related JBrowse link 11 101,288,258 101,302,286 RGD:2290270
G Elapor1 endosome-lysosome associated apoptosis and autophagy regulator 1 JBrowse link 3 108,455,679 108,536,745 RGD:2290270
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 JBrowse link 2 32,925,215 32,961,668 RGD:2290270
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha JBrowse link 2 18,842,255 18,998,291 RGD:2290270
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta JBrowse link 11 97,715,157 97,744,704 RGD:2290270
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase, type II, gamma JBrowse link 10 127,197,067 127,211,628 RGD:2290270
G Rab3gap1 RAB3 GTPase activating protein subunit 1 JBrowse link 1 127,868,755 127,943,876 RGD:2290270
G Rab3gap2 RAB3 GTPase activating protein subunit 2 JBrowse link 1 185,204,088 185,286,756 RGD:2290270
G Ralb v-ral simian leukemia viral oncogene B JBrowse link 1 119,470,305 119,504,782 RGD:2290270
G Sh3glb1 SH3-domain GRB2-like B1 (endophilin) JBrowse link 3 144,683,678 144,720,556 RGD:2290270
G Ulk1 unc-51 like kinase 1 JBrowse link 5 110,784,489 110,810,120 RGD:2290270
protein lipidation involved in autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg16l1 autophagy related 16-like 1 (S. cerevisiae) JBrowse link 1 87,756,007 87,792,428 RGD:2290270
G Atg5 autophagy related 5 JBrowse link 10 44,268,322 44,364,299 RGD:2290270
G Irgm1 immunity-related GTPase family M member 1 JBrowse link 11 48,865,245 48,871,420 RGD:9068941
G Irgm2 immunity-related GTPase family M member 2 JBrowse link 11 58,214,977 58,222,783 RGD:2290270
G Wipi2 WD repeat domain, phosphoinositide interacting 2 JBrowse link 5 142,629,533 142,669,672 RGD:2290270
protein localization to phagophore assembly site term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg13 autophagy related 13 JBrowse link 2 91,674,612 91,710,597 RGD:2290270
G Atg16l1 autophagy related 16-like 1 (S. cerevisiae) JBrowse link 1 87,756,007 87,792,428 RGD:2290270
G Atg9a autophagy related 9A JBrowse link 1 75,180,861 75,192,010 RGD:2290270
G Atg9b autophagy related 9B JBrowse link 5 24,384,181 24,392,143 RGD:2290270
G Mfn2 mitofusin 2 JBrowse link 4 147,873,586 147,904,909 RGD:2290270
G Pacs2 phosphofurin acidic cluster sorting protein 2 JBrowse link 12 113,014,454 113,074,401 RGD:2290270
G Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 JBrowse link 18 30,265,615 30,348,126 RGD:2290270
G Stx17 syntaxin 17 JBrowse link 4 48,124,906 48,186,507 RGD:2290270
G Trappc8 trafficking protein particle complex 8 JBrowse link 18 20,817,211 20,896,425 RGD:2290270
G Wdr45 WD repeat domain 45 JBrowse link X 7,721,987 7,728,201 RGD:2290270
G Wdr45b WD repeat domain 45B JBrowse link 11 121,327,203 121,354,447 RGD:2290270
G Wipi1 WD repeat domain, phosphoinositide interacting 1 JBrowse link 11 109,573,521 109,611,389 RGD:2290270
G Wipi2 WD repeat domain, phosphoinositide interacting 2 JBrowse link 5 142,629,533 142,669,672 RGD:2290270
regulation of autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C9orf72 C9orf72, member of C9orf72-SMCR8 complex JBrowse link 4 35,191,285 35,226,153 RGD:2290270
G Ift20 intraflagellar transport 20 JBrowse link 11 78,536,361 78,541,732 RGD:2290270
G Ift88 intraflagellar transport 88 JBrowse link 14 57,424,064 57,517,936 RGD:2290270
G Mtmr3 myotubularin related protein 3 JBrowse link 11 4,480,867 4,594,863 RGD:2290270
G Nprl2 NPR2 like, GATOR1 complex subunit JBrowse link 9 107,542,177 107,545,706 RGD:2290270
G Nprl3 nitrogen permease regulator-like 3 JBrowse link 11 32,231,963 32,267,707 RGD:2290270
G Pikfyve phosphoinositide kinase, FYVE type zinc finger containing JBrowse link 1 65,186,640 65,278,696 RGD:2290270
G Rab1b RAB1B, member RAS oncogene family JBrowse link 19 5,099,207 5,106,996 RGD:2290270
G Rnf5 ring finger protein 5 JBrowse link 17 34,601,099 34,603,561 RGD:2290270
G Tbc1d12 TBC1D12: TBC1 domain family, member 12 JBrowse link 19 38,836,579 38,919,670 RGD:2290270
G Tbc1d14 TBC1 domain family, member 14 JBrowse link 5 36,490,604 36,586,271 RGD:2290270
G Ubqln2 ubiquilin 2 JBrowse link X 153,498,232 153,501,562 RGD:2290270
substrate localization to autophagosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 5 144,876,495 144,965,899 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23164
    cellular process 17043
      cellular component organization or biogenesis 6338
        cellular component biogenesis 3000
          cellular component assembly 2758
            organelle assembly 857
              autophagosome assembly 93
                engulfment of target by autophagosome 1
                negative regulation of autophagosome assembly 14
                positive regulation of autophagosome assembly 11
                protein lipidation involved in autophagosome assembly 5
                protein localization to phagophore assembly site 13
                regulation of autophagosome assembly + 36
                substrate localization to autophagosome 1
Path 2
Term Annotations click to browse term
  biological_process 23164
    cellular process 17043
      cellular component organization or biogenesis 6338
        cellular component organization 6150
          organelle organization 3786
            vacuole organization 174
              autophagosome organization 98
                autophagosome assembly 93
                  engulfment of target by autophagosome 1
                  negative regulation of autophagosome assembly 14
                  positive regulation of autophagosome assembly 11
                  protein lipidation involved in autophagosome assembly 5
                  protein localization to phagophore assembly site 13
                  regulation of autophagosome assembly + 36
                  substrate localization to autophagosome 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.