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ONTOLOGY REPORT - ANNOTATIONS


Term:G2/M transition of mitotic cell cycle
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Accession:GO:0000086 term browser browse the term
Definition:The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
Synonyms:exact_synonym: mitotic G2/M transition


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G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:1624291
G Arpp19 cAMP-regulated phosphoprotein 19 JBrowse link 8 81,949,577 81,972,054 RGD:1624291
RGD:1600115
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:1624291
RGD:1600115
G Brsk1 BR serine/threonine kinase 1 JBrowse link 1 72,701,281 72,727,061 RGD:1624291
G Brsk2 BR serine/threonine kinase 2 JBrowse link 1 214,918,757 214,940,883 RGD:1624291
RGD:1600115
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:1624291
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:1624291
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:1624291
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:1624291
G Ccny cyclin Y JBrowse link 17 62,332,537 62,462,644 RGD:1624291
G Cdc25a cell division cycle 25A JBrowse link 8 117,953,223 117,971,552 RGD:13792537
G Cdc25b cell division cycle 25B JBrowse link 3 123,731,539 123,741,696 RGD:13792537
G Cdc25c cell division cycle 25C JBrowse link 18 27,528,768 27,550,316 RGD:1624291
RGD:13792537
G Cdc5l cell division cycle 5-like JBrowse link 9 17,949,764 17,988,514 RGD:619664
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:13792537
G Cdk14 cyclin-dependent kinase 14 JBrowse link 4 25,825,567 26,419,443 RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Cdkn2b cyclin-dependent kinase inhibitor 2B JBrowse link 5 107,834,353 107,857,428 RGD:1624291
RGD:1600115
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:1624291
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
G Cit citron rho-interacting serine/threonine kinase JBrowse link 12 46,334,669 46,494,152 RGD:628497
G Ensa endosulfine alpha JBrowse link 2 197,752,544 197,759,882 RGD:1600115
G Fbxl12 F-box and leucine-rich repeat protein 12 JBrowse link 8 21,656,636 21,662,755 RGD:13792537
G Fbxl15 F-box and leucine-rich repeat protein 15 JBrowse link 1 266,075,782 266,078,023 RGD:1624291
RGD:1600115
G Fbxl21 F-box and leucine-rich repeat protein 21 JBrowse link 17 8,505,771 8,520,208 RGD:13792537
G Fbxl22 F-box and leucine-rich repeat protein 22 JBrowse link 8 72,198,043 72,204,730 RGD:13792537
G Fbxl3 F-box and leucine-rich repeat protein 3 JBrowse link 15 93,647,307 93,667,395 RGD:13792537
G Fbxl6 F-box and leucine-rich repeat protein 6 JBrowse link 7 117,602,056 117,604,954 RGD:13792537
G Fbxl7 F-box and leucine-rich repeat protein 7 JBrowse link 2 79,067,907 79,439,987 RGD:1624291
G Fbxl8 F-box and leucine-rich repeat protein 8 JBrowse link 19 37,216,696 37,225,701 RGD:13792537
G Foxm1 forkhead box M1 JBrowse link 4 161,685,236 161,697,633 RGD:1600115
RGD:13792537
RGD:1624291
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:728684
G Kat14 lysine acetyltransferase 14 JBrowse link 3 138,508,899 138,549,437 RGD:1624291
G Kdm8 lysine demethylase 8 JBrowse link 1 196,838,460 196,854,192 RGD:1600115
RGD:1624291
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 JBrowse link 5 147,927,145 147,953,093 RGD:1600115
G Lats1 large tumor suppressor kinase 1 JBrowse link 1 1,784,078 1,817,310 RGD:1624291
G LOC100360828 cAMP-regulated phosphoprotein 19-like JBrowse link 8 119,105,962 119,106,371 RGD:1600115
G Mastl microtubule associated serine/threonine kinase-like JBrowse link 17 89,839,562 89,875,855 RGD:1624291
RGD:1600115
G Nes nestin JBrowse link 2 187,343,109 187,352,972 RGD:1624291
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:1624291
RGD:1600115
G Plk1 polo-like kinase 1 JBrowse link 1 192,115,990 192,125,969 RGD:1600115
RGD:1624291
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:1624291
G Skp2 S-phase kinase associated protein 2 JBrowse link 2 58,506,146 58,534,211 RGD:1624291
RGD:13792537
G Taf2 TATA-box binding protein associated factor 2 JBrowse link 7 94,698,987 94,755,924 RGD:1624291
G Tpd52l1 TPD52 like 1 JBrowse link 1 28,454,949 28,578,736 RGD:1624291
G Ush1c USH1 protein network component harmonin JBrowse link 1 102,207,096 102,256,779 RGD:1624291
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:1624291
mitotic cytokinesis checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:1600115
G Chmp4c charged multivesicular body protein 4C JBrowse link 2 93,574,554 93,641,497 RGD:1600115
RGD:1624291
G Vps4a vacuolar protein sorting 4 homolog A JBrowse link 19 39,230,050 39,243,298 RGD:1624291
RGD:1600115
G Zfyve19 zinc finger FYVE-type containing 19 JBrowse link 3 111,013,856 111,021,841 RGD:1624291
RGD:13792537
mitotic DNA replication checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07049960.1 RGD:13792537
G Cdc6 cell division cycle 6 JBrowse link 10 86,819,477 86,833,301 RGD:13792537
G Clspn claspin JBrowse link 5 144,577,670 144,617,507 RGD:1624291
RGD:13792537
G Hus1 HUS1 checkpoint clamp component JBrowse link 14 89,194,086 89,208,825 RGD:13792537
G LOC103690165 checkpoint protein HUS1B JBrowse link 17 34,691,084 34,694,690 RGD:13792537
G Nae1 NEDD8 activating enzyme E1 subunit 1 JBrowse link 19 653,510 680,378 RGD:1600115
RGD:1624291
G Orc1 origin recognition complex, subunit 1 JBrowse link 5 128,186,651 128,212,901 RGD:13792537
G Rad17 RAD17 checkpoint clamp loader component JBrowse link 2 30,634,353 30,664,618 RGD:13792537
G Ticrr TOPBP1-interacting checkpoint and replication regulator JBrowse link 1 141,391,738 141,433,615 RGD:13792537
G Topbp1 DNA topoisomerase II binding protein 1 JBrowse link 8 111,790,655 111,835,224 RGD:13792537
G Zfp830 zinc finger protein 830 JBrowse link 10 70,118,250 70,119,714 RGD:1624291
RGD:13792537
RGD:1600115
mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07049960.1 RGD:13792537
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:1624291
G Brsk1 BR serine/threonine kinase 1 JBrowse link 1 72,701,281 72,727,061 RGD:1624291
G Brsk2 BR serine/threonine kinase 2 JBrowse link 1 214,918,757 214,940,883 RGD:8554801
G Ccng1 cyclin G1 JBrowse link 10 25,903,925 25,910,298 RGD:2316029
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:1624291
RGD:13792537
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1600115
RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Clspn claspin JBrowse link 5 144,577,670 144,617,507 RGD:1624291
RGD:13792537
G Donson DNA replication fork stabilization factor DONSON JBrowse link 11 31,834,608 31,847,751 RGD:1624291
G Foxn3 forkhead box N3 JBrowse link 6 123,183,720 123,577,719 RGD:1624291
G Foxo4 forkhead box O4 JBrowse link X 71,155,284 71,162,158 RGD:1624291
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
RGD:1600115
G Ier3 immediate early response 3 JBrowse link 20 3,438,798 3,440,002 RGD:1624291
G LOC100302465 hypothetical LOC100302465 JBrowse link 1 206,324,763 206,417,143 RGD:1624291
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase JBrowse link 4 147,744,673 147,756,462 RGD:1624291
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1624291
RGD:13792537
RGD:1600115
G Mrnip MRN complex interacting protein JBrowse link 10 35,680,687 35,704,685 RGD:1624291
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:1624291
RGD:13792537
RGD:1600115
G Nop53 NOP53 ribosome biogenesis factor JBrowse link 1 77,836,522 77,843,991 RGD:1624291
G Syf2 SYF2 pre-mRNA-splicing factor JBrowse link 5 153,269,638 153,277,562 RGD:1624291
G Taok1 TAO kinase 1 JBrowse link 10 62,542,870 62,630,341 RGD:1600115
RGD:1624291
G Taok2 TAO kinase 2 JBrowse link 1 198,301,789 198,354,601 RGD:1600115
RGD:1624291
G Taok3 TAO kinase 3 JBrowse link 12 45,037,951 45,116,593 RGD:1600115
RGD:1624291
G Ticrr TOPBP1-interacting checkpoint and replication regulator JBrowse link 1 141,391,738 141,433,615 RGD:13792537
G Topbp1 DNA topoisomerase II binding protein 1 JBrowse link 8 111,790,655 111,835,224 RGD:13792537
G Trim39 tripartite motif-containing 39 JBrowse link 20 2,500,691 2,514,546 RGD:1600115
RGD:1624291
mitotic G2/M transition checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:1624291
RGD:1600115
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1624291
RGD:1600115
negative regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aven apoptosis and caspase activation inhibitor JBrowse link 3 103,980,612 104,117,193 RGD:13792537
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:2316109
G Fhl1 four and a half LIM domains 1 JBrowse link X 159,112,516 159,172,528 RGD:1624291
RGD:1600115
G Gpr132 G protein-coupled receptor 132 JBrowse link 6 137,652,213 137,671,658 RGD:1624291
RGD:13792537
G LOC100911456 migration and invasion-inhibitory protein-like JBrowse link 5 164,548,657 164,555,842 RGD:1600115
G Miip migration and invasion inhibitory protein JBrowse link 5 164,672,464 164,679,503 RGD:1600115
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 JBrowse link 15 47,211,682 47,270,343 RGD:1624291
G Rad21 RAD21 cohesin complex component JBrowse link 7 91,511,755 91,538,673 RGD:1624291
G Usp47 ubiquitin specific peptidase 47 JBrowse link 1 176,854,589 176,937,763 RGD:1624291
positive regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:1624291
G Camk2d calcium/calmodulin-dependent protein kinase II delta JBrowse link 2 230,900,907 231,132,207 RGD:2303063
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:1624291
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:1624291
RGD:1600115
G Cdc25a cell division cycle 25A JBrowse link 8 117,953,223 117,971,552 RGD:13792537
G Cdc25b cell division cycle 25B JBrowse link 3 123,731,539 123,741,696 RGD:13792537
G Cdc25c cell division cycle 25C JBrowse link 18 27,528,768 27,550,316 RGD:13792537
G Cdc7 cell division cycle 7 JBrowse link 14 3,826,658 3,846,891 RGD:1624291
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:1624291
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:1624291
RGD:1600115
G Dbf4b DBF4 zinc finger B JBrowse link 10 90,710,468 90,723,313 RGD:1624291
G Dtl denticleless E3 ubiquitin protein ligase homolog JBrowse link 13 110,219,276 110,257,345 RGD:1624291
G Fbxo5 F-box protein 5 JBrowse link 1 42,461,277 42,467,646 RGD:1624291
G Hspa2 heat shock protein family A (Hsp70) member 2 JBrowse link 6 99,433,575 99,436,288 RGD:1624291
G Mecp2 methyl CpG binding protein 2 JBrowse link X 156,650,389 156,713,813 RGD:1600115
RGD:1624291
G Mta3 metastasis associated 1 family, member 3 JBrowse link 6 6,904,449 7,036,929 RGD:1624291
G Pbx1 PBX homeobox 1 JBrowse link 13 86,390,741 86,671,460 RGD:1624291
G Rab11a RAB11a, member RAS oncogene family JBrowse link 8 70,192,975 70,215,719 RGD:1624291
G Rad51b RAD51 paralog B JBrowse link 6 102,473,978 103,018,185 RGD:1624291
G Rad51c RAD51 paralog C JBrowse link 10 74,697,713 74,724,004 RGD:1624291
G Rcc2 regulator of chromosome condensation 2 JBrowse link 5 159,220,531 159,236,313 RGD:1624291
G Sin3a SIN3 transcription regulator family member A JBrowse link 8 61,748,590 61,803,314 RGD:1624291
G Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 JBrowse link 4 7,076,710 7,108,334 RGD:9586362
G Stox1 storkhead box 1 JBrowse link 20 32,276,857 32,353,677 RGD:1624291
G Vps4b vacuolar protein sorting 4 homolog B JBrowse link 13 26,825,261 26,850,460 RGD:1624291
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:1624291
positive regulation of transcription involved in G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Esrrb estrogen-related receptor beta JBrowse link 6 110,360,940 110,458,406 RGD:1624291
RGD:1600115
regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnb3 cyclin B3 JBrowse link X 16,300,752 16,402,206 RGD:1600115
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:13792537
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Cenpf centromere protein F JBrowse link 13 108,132,499 108,178,609 RGD:1624291
G Ctc1 CST telomere replication complex component 1 JBrowse link 10 55,596,172 55,616,873 RGD:1624291
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 JBrowse link 17 81,173,238 81,196,012 RGD:1624291
G Kcnh5 potassium voltage-gated channel subfamily H member 5 JBrowse link 6 97,872,831 98,157,087 RGD:1624291
G Kif14 kinesin family member 14 JBrowse link 13 53,350,073 53,421,992 RGD:1624291
G Pkia cAMP-dependent protein kinase inhibitor alpha JBrowse link 2 96,593,185 96,668,222 RGD:1624291
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:1625621
G Rnaseh2b ribonuclease H2, subunit B JBrowse link 15 45,422,010 45,472,792 RGD:1624291
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rint1 RAD50 interactor 1 JBrowse link 4 7,851,602 7,885,446 RGD:1624291
RGD:13792537
regulation of transcription involved in G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bach1 BTB domain and CNC homolog 1 JBrowse link 11 27,364,913 27,398,713 RGD:1624291
signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    cellular process 18452
      cell cycle process 1202
        cell cycle phase transition 428
          mitotic cell cycle phase transition 387
            G2/M transition of mitotic cell cycle 127
              negative regulation of G2/M transition of mitotic cell cycle + 50
              positive regulation of G2/M transition of mitotic cell cycle + 27
              regulation of G2/M transition of mitotic cell cycle + 87
              regulation of transcription involved in G2/M transition of mitotic cell cycle + 2
Path 2
Term Annotations click to browse term
  biological_process 19678
    cellular process 18452
      cell cycle 1527
        cell cycle process 1202
          cell cycle phase transition 428
            mitotic cell cycle phase transition 387
              G2/M transition of mitotic cell cycle 127
                negative regulation of G2/M transition of mitotic cell cycle + 50
                positive regulation of G2/M transition of mitotic cell cycle + 27
                regulation of G2/M transition of mitotic cell cycle + 87
                regulation of transcription involved in G2/M transition of mitotic cell cycle + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.