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ONTOLOGY REPORT - ANNOTATIONS


Term:G2/M transition of mitotic cell cycle
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Accession:GO:0000086 term browser browse the term
Definition:The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
Synonyms:exact_synonym: mitotic G2/M transition


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G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 7 93,147,217 93,355,231 RGD:9068941
G ARPP19 cAMP regulated phosphoprotein 19 JBrowse link 15 49,813,313 49,835,051 RGD:9068941
G BIRC5 baculoviral IAP repeat containing 5 JBrowse link 17 77,842,724 77,854,159 RGD:9068941
G BRSK1 BR serine/threonine kinase 1 JBrowse link 19 61,021,479 61,046,190 RGD:9068941
G BRSK2 BR serine/threonine kinase 2 JBrowse link 11 1,473,129 1,521,339 RGD:9068941
G CALM1 calmodulin 1 JBrowse link 14 90,367,086 90,378,361 RGD:9068941
G CALM2 calmodulin 2 JBrowse link 2A 48,204,518 48,220,697 RGD:9068941
G CALM3 calmodulin 3 JBrowse link 19 52,121,687 52,131,135 RGD:9068941
G CCNA2 cyclin A2 JBrowse link 4 125,153,810 125,161,370 RGD:9068941
G CCNY cyclin Y JBrowse link 10 35,950,490 36,273,282 RGD:9068941
G CDC25C cell division cycle 25C JBrowse link 5 139,795,138 139,843,395 RGD:9068941
G CDK14 cyclin dependent kinase 14 JBrowse link 7 96,210,658 96,817,952 RGD:9068941
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 37,436,963 37,445,599 RGD:9068941
G CDKN2B cyclin dependent kinase inhibitor 2B JBrowse link 9 22,455,662 22,462,156 RGD:9068941
G CHEK1 checkpoint kinase 1 JBrowse link 11 124,359,218 124,410,385 RGD:9068941
G CHEK2 checkpoint kinase 2 JBrowse link 22 27,455,226 27,512,555 RGD:9068941
G CIT citron rho-interacting serine/threonine kinase JBrowse link 12 120,641,747 120,832,511 RGD:9068941
G FBXL15 F-box and leucine rich repeat protein 15 JBrowse link 10 102,488,353 102,492,301 RGD:9068941
G FBXL7 F-box and leucine rich repeat protein 7 JBrowse link 5 15,643,666 16,075,623 RGD:9068941
G FOXM1 forkhead box M1 JBrowse link 12 2,910,028 2,930,503 RGD:9068941
G GADD45A growth arrest and DNA damage inducible alpha JBrowse link 1 68,880,912 68,884,188 RGD:9068941
G KAT14 lysine acetyltransferase 14 JBrowse link 20 18,082,402 18,128,470 RGD:9068941
G KDM8 lysine demethylase 8 JBrowse link 16 27,577,230 27,595,164 RGD:9068941
G LATS1 large tumor suppressor kinase 1 JBrowse link 6 152,182,394 152,239,276 RGD:9068941
G MASTL microtubule associated serine/threonine kinase like JBrowse link 10 27,626,892 27,658,180 RGD:9068941
G NES nestin JBrowse link 1 135,835,456 135,844,094 RGD:9068941
G PLCB1 phospholipase C beta 1 JBrowse link 20 7,887,773 8,636,019 RGD:9068941
G PLK1 polo like kinase 1 JBrowse link 16 23,928,773 23,940,779 RGD:9068941
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D JBrowse link 17 59,824,566 59,887,015 RGD:9068941
G SKP2 S-phase kinase associated protein 2 JBrowse link 5 79,460,989 79,493,000 RGD:9068941
G TAF2 TATA-box binding protein associated factor 2 JBrowse link 8 119,170,327 119,271,405 RGD:9068941
G TPD52L1 TPD52 like 1 JBrowse link 6 127,062,800 127,172,174 RGD:9068941
G USH1C USH1 protein network component harmonin JBrowse link 11 17,233,854 17,284,256 RGD:9068941
G WNT10B Wnt family member 10B JBrowse link 12 40,659,106 40,665,734 RGD:9068941
mitotic cytokinesis checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CHMP4C charged multivesicular body protein 4C JBrowse link 8 79,879,823 79,906,859 RGD:9068941
G VPS4A vacuolar protein sorting 4 homolog A JBrowse link 16 68,946,466 69,085,714 RGD:9068941
G ZFYVE19 zinc finger FYVE-type containing 19 JBrowse link 15 37,999,283 38,006,744 RGD:9068941
mitotic DNA replication checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CLSPN claspin JBrowse link 1 36,168,444 36,218,544 RGD:9068941
G NAE1 NEDD8 activating enzyme E1 subunit 1 JBrowse link 16 66,221,829 66,246,648 RGD:9068941
G ZNF830 zinc finger protein 830 JBrowse link 17 22,115,803 22,117,467 RGD:9068941
mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BLM BLM RecQ like helicase JBrowse link 15 88,607,157 88,707,864 RGD:9068941
G BRSK1 BR serine/threonine kinase 1 JBrowse link 19 61,021,479 61,046,190 RGD:9068941
G C10H10orf90 chromosome 10 C10orf90 homolog JBrowse link 10 127,258,584 127,505,349 RGD:9068941
G CCNG1 cyclin G1 JBrowse link 5 165,591,279 165,598,728 RGD:9068941
G CDK1 cyclin dependent kinase 1 JBrowse link 10 59,647,993 59,664,434 RGD:9068941
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 JBrowse link 17 9,738,144 9,748,989 RGD:9068941
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 37,436,963 37,445,599 RGD:9068941
G CLSPN claspin JBrowse link 1 36,168,444 36,218,544 RGD:9068941
G DONSON DNA replication fork stabilization factor DONSON JBrowse link 21 33,317,147 33,328,132 RGD:9068941
G FOXN3 forkhead box N3 JBrowse link 14 89,134,673 89,468,817 RGD:9068941
G FOXO4 forkhead box O4 JBrowse link X 70,422,504 70,429,971 RGD:9068941
G HMGA2 high mobility group AT-hook 2 RGD:9068941
G IER3 immediate early response 3 JBrowse link 6 31,357,853 31,359,205 RGD:9068941
G MBD4 methyl-CpG binding domain 4, DNA glycosylase JBrowse link 3 133,842,156 133,851,450 RGD:9068941
G MRE11 MRE11 homolog, double strand break repair nuclease JBrowse link 11 92,908,403 92,985,966 RGD:9068941
G MRNIP MRN complex interacting protein JBrowse link 5 182,299,111 182,340,717 RGD:9068941
G NBN nibrin JBrowse link 8 88,575,198 88,626,200 RGD:9068941
G NOP53 NOP53 ribosome biogenesis factor JBrowse link 19 53,393,238 53,404,708 RGD:9068941
G SYF2 SYF2 pre-mRNA splicing factor JBrowse link 1 25,397,241 25,406,817 RGD:9068941
G TAOK1 TAO kinase 1 JBrowse link 17 27,737,904 27,898,436 RGD:9068941
G TAOK2 TAO kinase 2 JBrowse link 16 30,347,229 30,365,647 RGD:9068941
G TAOK3 TAO kinase 3 JBrowse link 12 119,109,642 119,332,679 RGD:9068941
G TRIM39 tripartite motif containing 39 JBrowse link 6 30,975,260 30,992,628 RGD:9068941
mitotic G2/M transition checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRCA1 BRCA1 DNA repair associated JBrowse link 17 14,429,601 14,506,815 RGD:9068941
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 JBrowse link 17 9,738,144 9,748,989 RGD:9068941
negative regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CHEK1 checkpoint kinase 1 JBrowse link 11 124,359,218 124,410,385 RGD:9068941
G FHL1 four and a half LIM domains 1 JBrowse link X 135,538,152 135,602,375 RGD:9068941
G GPR132 G protein-coupled receptor 132 JBrowse link 14 105,482,545 105,498,527 RGD:9068941
G PINX1 PIN2 (TERF1) interacting telomerase inhibitor 1 RGD:9068941
G RAD21 RAD21 cohesin complex component JBrowse link 8 116,063,503 116,092,421 RGD:9068941
G RFPL1 ret finger protein like 1 JBrowse link 22 28,289,366 28,292,184 RGD:9068941
G USP47 ubiquitin specific peptidase 47 JBrowse link 11 11,703,617 11,821,074 RGD:9068941
positive regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APP amyloid beta precursor protein JBrowse link 21 25,683,236 25,995,262 RGD:9068941
G BRD4 bromodomain containing 4 JBrowse link 19 15,752,096 15,789,630 RGD:9068941
G CAMK2D calcium/calmodulin dependent protein kinase II delta JBrowse link 4 116,520,393 116,836,244 RGD:9068941
G CCNB1 cyclin B1 JBrowse link 5 46,394,362 46,405,332 RGD:9068941
G CCND1 cyclin D1 JBrowse link 11 68,029,134 68,041,553 RGD:9068941
G CDC7 cell division cycle 7 JBrowse link 1 92,902,323 92,927,203 RGD:9068941
G CDK1 cyclin dependent kinase 1 JBrowse link 10 59,647,993 59,664,434 RGD:9068941
G CDK4 cyclin dependent kinase 4 JBrowse link 12 31,434,594 31,438,876 RGD:9068941
G DBF4B DBF4 zinc finger B JBrowse link 17 12,744,110 12,790,302 RGD:9068941
G DTL denticleless E3 ubiquitin protein ligase homolog JBrowse link 1 192,466,408 192,535,071 RGD:9068941
G FBXO5 F-box protein 5 JBrowse link 6 155,481,767 155,494,689 RGD:9068941
G HSPA2 heat shock protein family A (Hsp70) member 2 JBrowse link 14 63,373,462 63,376,240 RGD:9068941
G MECP2 methyl-CpG binding protein 2 JBrowse link X 153,458,248 153,527,854 RGD:9068941
G MTA3 metastasis associated 1 family member 3 JBrowse link 2A 43,444,119 43,694,314 RGD:9068941
G PBX1 PBX homeobox 1 JBrowse link 1 143,778,426 144,104,493 RGD:9068941
G RAB11A RAB11A, member RAS oncogene family JBrowse link 15 63,088,084 63,108,077 RGD:9068941
G RAD51B RAD51 paralog B JBrowse link 14 67,277,400 68,189,780 RGD:9068941
G RAD51C RAD51 paralog C JBrowse link 17 57,621,552 57,658,920 RGD:9068941
G RCC2 regulator of chromosome condensation 2 JBrowse link 1 17,409,432 17,440,769 RGD:9068941
G SIN3A SIN3 transcription regulator family member A JBrowse link 15 73,881,500 73,966,560 RGD:9068941
G SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 JBrowse link 7 154,977,708 155,013,783 RGD:9068941
G STOX1 storkhead box 1 JBrowse link 10 67,882,669 67,896,410 RGD:9068941
G VPS4B vacuolar protein sorting 4 homolog B JBrowse link 18 60,062,080 60,095,109 RGD:9068941
G WNT10B Wnt family member 10B JBrowse link 12 40,659,106 40,665,734 RGD:9068941
positive regulation of transcription involved in G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ESRRB estrogen related receptor beta JBrowse link 14 75,659,836 76,264,827 RGD:9068941
regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 22,420,748 22,447,243 RGD:9068941
G CENPF centromere protein F JBrowse link 1 195,025,577 195,086,518 RGD:9068941
G CTC1 CST telomere replication complex component 1 JBrowse link 17 48,142,864 48,165,537 RGD:9068941
G HACD1 3-hydroxyacyl-CoA dehydratase 1 JBrowse link 10 18,182,727 18,196,854 RGD:9068941
G KCNH5 potassium voltage-gated channel subfamily H member 5 JBrowse link 14 61,560,591 61,889,137 RGD:9068941
G KIF14 kinesin family member 14 JBrowse link 1 180,462,381 180,528,302 RGD:9068941
G PKIA cAMP-dependent protein kinase inhibitor alpha JBrowse link 8 76,677,518 76,766,673 RGD:9068941
G PRKCQ protein kinase C theta JBrowse link 10 6,440,316 6,528,828 RGD:9068941
G RNASEH2B ribonuclease H2 subunit B JBrowse link 13 50,804,013 50,839,440 RGD:9068941
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RINT1 RAD50 interactor 1 JBrowse link 7 110,252,778 110,287,708 RGD:9068941
regulation of transcription involved in G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BACH1 BTB domain and CNC homolog 1 JBrowse link 21 29,126,108 29,173,835 RGD:9068941
signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATM ATM serine/threonine kinase JBrowse link 11 106,584,228 106,728,457 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12491
    cellular process 11602
      cell cycle process 997
        cell cycle phase transition 363
          mitotic cell cycle phase transition 323
            G2/M transition of mitotic cell cycle 102
              negative regulation of G2/M transition of mitotic cell cycle + 38
              positive regulation of G2/M transition of mitotic cell cycle + 24
              regulation of G2/M transition of mitotic cell cycle + 70
              regulation of transcription involved in G2/M transition of mitotic cell cycle + 2
Path 2
Term Annotations click to browse term
  biological_process 12491
    cellular process 11602
      cell cycle 1246
        cell cycle process 997
          cell cycle phase transition 363
            mitotic cell cycle phase transition 323
              G2/M transition of mitotic cell cycle 102
                negative regulation of G2/M transition of mitotic cell cycle + 38
                positive regulation of G2/M transition of mitotic cell cycle + 24
                regulation of G2/M transition of mitotic cell cycle + 70
                regulation of transcription involved in G2/M transition of mitotic cell cycle + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.