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ONTOLOGY REPORT - ANNOTATIONS


Term:SNARE binding
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Accession:GO:0000149 term browser browse the term
Definition:Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
Synonyms:exact_synonym: SNAP receptor binding
 xref: reactome:R-HSA-210426 "Glutamate synaptic vesicle docking and priming";   reactome:R-HSA-210430 "release of L-Glutamate at the synapse";   reactome:R-HSA-265166 "Exocytosis of Insulin";   reactome:R-HSA-372505 "Acetylcholine synaptic vesicle docking and priming";   reactome:R-HSA-372529 "Release of acetylcholine at the synapse";   reactome:R-HSA-374899 "Release of noradrenaline at the synapse";   reactome:R-HSA-374922 "Noradrenalin synaptic vesicle docking and priming";   reactome:R-HSA-376357 "Vamp7 associated Lysosome to Plasma membrane transport";   reactome:R-HSA-376364 "Vamp8 associated secretory vesicle to plasma membrane transport";   reactome:R-HSA-376369 "Vamp2 associated secretory vesicle to plasma membrane transport";   reactome:R-HSA-380574 "Dopamine synaptic vesicle docking and priming";   reactome:R-HSA-380869 "Release of docked dopamine loaded synaptic vesicle";   reactome:R-HSA-380901 "Release of docked serotonin loaded synaptic vesicle";   reactome:R-HSA-380905 "Serotonin loaded synaptic vesicle docking and priming";   reactome:R-HSA-888589 "Release of GABA at the synapse";   reactome:R-HSA-9023173 "Insulin secretory granule docks at the plasma membrane";   reactome:R-HSA-917744 "GABA loaded synaptic vesicle Docking and Priming"


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SNARE binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy6 adenylate cyclase 6 JBrowse link 7 140,270,678 140,291,722 RGD:8553247
G Ankrd27 ankyrin repeat domain 27 JBrowse link 1 91,857,048 91,958,763 RGD:1624291
RGD:13792537
RGD:8554110
G Baiap3 BAI1-associated protein 3 JBrowse link 10 14,601,133 14,613,881 RGD:1624291
G Capn10 calpain 10 JBrowse link 9 100,104,000 100,112,833 RGD:8553339
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:632372
G Cav2 caveolin 2 JBrowse link 4 44,573,264 44,580,640 RGD:632372
G Cplx1 complexin 1 JBrowse link 14 2,194,895 2,226,610 RGD:727333
RGD:13792537
RGD:2311133
RGD:2311128
G Cplx2 complexin 2 JBrowse link 17 10,756,871 10,828,811 RGD:727333
RGD:13792537
RGD:7205655
G Cplx3 complexin 3 JBrowse link 8 62,379,502 62,386,264 RGD:1624291
RGD:13792537
G Cplx4 complexin 4 JBrowse link 18 61,657,216 61,672,641 RGD:1624291
RGD:13792537
G Exoc3 exocyst complex component 3 JBrowse link 1 31,700,953 31,731,726 RGD:13792537
G Exoc3l1 exocyst complex component 3-like 1 JBrowse link 19 37,245,269 37,252,789 RGD:13792537
G Exoc3l2 exocyst complex component 3-like 2 JBrowse link 1 80,372,708 80,404,275 RGD:13792537
G Exoc3l4 exocyst complex component 3-like 4 JBrowse link 6 135,866,132 135,880,724 RGD:13792537
G Gosr2 golgi SNAP receptor complex member 2 JBrowse link 10 91,735,772 91,756,123 RGD:13792537
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link 2 179,584,302 179,704,629 RGD:633462
G Kcnb1 potassium voltage-gated channel subfamily B member 1 JBrowse link 3 163,850,785 163,935,610 RGD:10047372
G LOC100910446 syntaxin-7-like JBrowse link 1 23,542,376 23,560,911 RGD:13792537
G LOC103690878 syntaxin-3-like JBrowse link X 79,742,224 79,743,117 RGD:13792537
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:13792537
G Myo5a myosin VA JBrowse link 8 82,038,966 82,156,507 RGD:1581734
G Napa NSF attachment protein alpha JBrowse link 1 77,994,227 78,012,846 RGD:70701
RGD:633462
RGD:11558001
G Napb NSF attachment protein beta JBrowse link 3 143,017,571 143,063,904 RGD:633462
G Nbas NBAS subunit of NRZ tethering complex JBrowse link 6 38,474,773 38,777,146 RGD:1624291
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase JBrowse link 10 91,879,608 91,986,242 RGD:1600115
G Picalm phosphatidylinositol binding clathrin assembly protein JBrowse link 1 154,377,229 154,458,966 RGD:13506237
RGD:13792537
RGD:1624291
RGD:1600115
G Sec24a SEC24 homolog A, COPII coat complex component JBrowse link 10 37,138,539 37,215,899 RGD:13792537
G Sec24b SEC24 homolog B, COPII coat complex component JBrowse link 2 230,286,886 230,356,887 RGD:13792537
G Sec24c SEC24 homolog C, COPII coat complex component JBrowse link 15 4,035,196 4,057,209 RGD:1624291
RGD:13792537
G Sec24d SEC24 homolog D, COPII coat complex component JBrowse link 2 227,455,704 227,562,801 RGD:1624291
RGD:13792537
G Septin8 septin 8 JBrowse link 10 38,877,422 38,906,480 RGD:13702278
G Snap25 synaptosome associated protein 25 JBrowse link 3 129,697,408 129,788,417 RGD:730202
RGD:12793053
RGD:12793015
RGD:1624291
RGD:70701
RGD:4892592
G Snap91 synaptosome associated protein 91 JBrowse link 8 94,447,558 94,564,772 RGD:13506237
RGD:13792537
G Snapin SNAP-associated protein JBrowse link 2 189,878,159 189,880,743 RGD:1624291
RGD:13792537
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:1624291
G Stx11 syntaxin 11 JBrowse link 1 7,039,160 7,064,870 RGD:13792537
G Stx12 syntaxin 12 JBrowse link 5 151,044,050 151,072,893 RGD:13792537
G Stx16 syntaxin 16 JBrowse link 3 172,154,739 172,183,699 RGD:13792537
G Stx17 syntaxin 17 JBrowse link 5 63,866,346 63,926,276 RGD:8553381
RGD:13792537
RGD:1624291
G Stx1a syntaxin 1A JBrowse link 12 24,682,050 24,710,002 RGD:1581734
RGD:13792537
RGD:12793053
RGD:12793015
RGD:1624291
RGD:70701
RGD:4892592
G Stx1b syntaxin 1B JBrowse link 1 199,251,842 199,270,465 RGD:13792537
G Stx2 syntaxin 2 JBrowse link 12 31,324,203 31,360,249 RGD:1298910
RGD:13792537
G Stx2_v1 syntaxin 2, variant 1 RGD:1298910
G Stx2_v2 syntaxin 2, variant 2 RGD:1298910
G Stx2_v3 syntaxin 2, variant 3 RGD:1298910
G Stx2_v4 syntaxin 2, variant 4 RGD:1298910
G Stx3 syntaxin 3 JBrowse link 1 228,137,781 228,195,004 RGD:13792537
G Stx4 syntaxin 4 JBrowse link 1 199,287,384 199,295,606 RGD:634161
RGD:13792537
RGD:1624291
RGD:1600115
G Stx5 syntaxin 5 JBrowse link 1 224,939,497 224,955,658 RGD:13792537
G Stx6 syntaxin 6 JBrowse link 13 72,804,218 72,850,757 RGD:13792537
G Stx7 syntaxin 7 JBrowse link 1 22,241,655 22,281,850 RGD:4892614
RGD:13792537
RGD:1624291
G Stx8 syntaxin 8 JBrowse link 10 54,512,922 54,753,302 RGD:13792537
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:2311128
RGD:2311133
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:13702278
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:7205652
RGD:13792537
RGD:11535104
RGD:11079189
RGD:10047386
RGD:7241021
RGD:7205655
G Syt10 synaptotagmin 10 JBrowse link 7 130,769,039 130,827,030 RGD:1624291
RGD:13792537
G Syt11 synaptotagmin 11 JBrowse link 2 188,112,301 188,138,180 RGD:1624291
RGD:13792537
G Syt12 synaptotagmin 12 JBrowse link 1 219,690,013 219,719,359 RGD:13792537
G Syt13 synaptotagmin 13 JBrowse link 3 81,814,287 81,852,454 RGD:13792537
G Syt15 synaptotagmin 15 JBrowse link 16 10,554,136 10,564,934 RGD:13792537
G Syt17 synaptotagmin 17 JBrowse link 1 188,034,614 188,101,590 RGD:13792537
G Syt2 synaptotagmin 2 JBrowse link 13 51,569,248 51,577,824 RGD:13792537
G Syt3 synaptotagmin 3 JBrowse link 1 100,379,236 100,407,862 RGD:7241021
RGD:13792537
RGD:11079189
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:7241021
RGD:13792537
RGD:11535104
G Syt5 synaptotagmin 5 JBrowse link 1 72,859,806 72,867,934 RGD:1624291
RGD:13792537
G Syt6 synaptotagmin 6 JBrowse link 2 206,064,181 206,119,034 RGD:13792537
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:1624291
RGD:13792537
G Syt8 synaptotagmin 8 JBrowse link 1 215,605,408 215,607,602 RGD:13792537
G Syt9 synaptotagmin 9 JBrowse link 1 171,592,703 171,769,780 RGD:1624291
RGD:13792537
G Tnfaip2 TNF alpha induced protein 2 JBrowse link 6 135,890,869 135,903,647 RGD:13792537
G Trim9 tripartite motif-containing 9 JBrowse link 6 92,660,026 92,760,036 RGD:631246
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:2311133
G Uvrag UV radiation resistance associated JBrowse link 1 163,844,804 164,101,568 RGD:1624291
RGD:13792537
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:70701
RGD:12793053
RGD:12793015
RGD:1624291
G Vamp3 vesicle-associated membrane protein 3 JBrowse link 5 168,126,157 168,136,628 RGD:4892592
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:13792537
G Vps50 VPS50 subunit of EARP/GARPII complex JBrowse link 4 28,441,255 28,551,784 RGD:1624291
G Vti1a vesicle transport through interaction with t-SNAREs 1A JBrowse link 1 276,310,072 276,508,635 RGD:13792537
G Vti1b vesicle transport through interaction with t-SNAREs 1B JBrowse link 6 102,340,261 102,353,612 RGD:1624291
RGD:13792537
RGD:1600115
syntaxin binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07053516.1 RGD:13792537
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:1624291
G Abcc9 ATP binding cassette subfamily C member 9 JBrowse link 4 176,806,098 176,928,540 RGD:1598641
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Baiap3 BAI1-associated protein 3 JBrowse link 10 14,601,133 14,613,881 RGD:1624291
G Bet1 Bet1 golgi vesicular membrane trafficking protein JBrowse link 4 29,082,368 29,092,638 RGD:8553381
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:1624291
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:632372
G Cav2 caveolin 2 JBrowse link 4 44,573,264 44,580,640 RGD:632372
G Cplx3 complexin 3 JBrowse link 8 62,379,502 62,386,264 RGD:1600115
G Cplx4 complexin 4 JBrowse link 18 61,657,216 61,672,641 RGD:1600115
G Doc2b double C2 domain beta JBrowse link 10 63,921,255 63,952,944 RGD:1600115
RGD:1624291
G Golga2 golgin A2 JBrowse link 3 11,317,328 11,337,569 RGD:1624291
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 JBrowse link 5 135,860,578 135,870,535 RGD:1624291
G Napa NSF attachment protein alpha JBrowse link 1 77,994,227 78,012,846 RGD:1624291
RGD:13792537
RGD:633462
G Napb NSF attachment protein beta JBrowse link 3 143,017,571 143,063,904 RGD:1624291
RGD:13792537
RGD:633462
RGD:1600115
G Napg NSF attachment protein gamma JBrowse link 18 58,325,319 58,344,071 RGD:13792537
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase JBrowse link 10 91,879,608 91,986,242 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
G Rab4a RAB4A, member RAS oncogene family JBrowse link 19 56,585,598 56,613,078 RGD:2306283
G Scfd1 sec1 family domain containing 1 JBrowse link 6 72,124,408 72,202,703 RGD:633773
RGD:13792537
RGD:8553381
RGD:2312423
G Scfd2 sec1 family domain containing 2 JBrowse link 14 36,216,002 36,543,661 RGD:13792537
G Sec22b SEC22 homolog B, vesicle trafficking protein JBrowse link 2 200,076,079 200,096,861 RGD:8553381
G Septin5 septin 5 JBrowse link 11 86,516,377 86,522,169 RGD:1302866
G Snap23 synaptosome associated protein 23 JBrowse link 3 112,333,972 112,362,960 RGD:634161
RGD:13792537
RGD:1624291
G Snap25 synaptosome associated protein 25 JBrowse link 3 129,697,408 129,788,417 RGD:13792537
G Snap29 synaptosome associated protein 29 JBrowse link 11 87,827,633 87,858,107 RGD:13792537
G Snap47 synaptosome associated protein 47 JBrowse link 10 45,757,196 45,798,734 RGD:13792537
G Sptan1 spectrin, alpha, non-erythrocytic 1 JBrowse link 3 8,534,437 8,599,259 RGD:2306291
G Stx16 syntaxin 16 JBrowse link 3 172,154,739 172,183,699 RGD:1624291
G Stx6 syntaxin 6 JBrowse link 13 72,804,218 72,850,757 RGD:1624291
G Stx7 syntaxin 7 JBrowse link 1 22,241,655 22,281,850 RGD:1624291
G Stx8 syntaxin 8 JBrowse link 10 54,512,922 54,753,302 RGD:1624291
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:629534
RGD:13792537
RGD:1624291
G Stxbp2 syntaxin binding protein 2 JBrowse link 12 2,180,101 2,191,863 RGD:730001
RGD:13792537
G Stxbp3 syntaxin binding protein 3 JBrowse link 2 211,595,763 211,638,756 RGD:2306290
RGD:13792537
RGD:1624291
G Stxbp4 syntaxin binding protein 4 JBrowse link 10 78,005,745 78,168,641 RGD:1624291
G Stxbp5 syntaxin binding protein 5 JBrowse link 1 3,858,917 4,011,684 RGD:1624291
RGD:13792537
G Stxbp5l syntaxin binding protein 5-like JBrowse link 11 66,246,624 66,566,331 RGD:1624291
RGD:13792537
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:61762
RGD:13792537
RGD:11535116
G Syt10 synaptotagmin 10 JBrowse link 7 130,769,039 130,827,030 RGD:13792537
G Syt12 synaptotagmin 12 JBrowse link 1 219,690,013 219,719,359 RGD:13792537
G Syt17 synaptotagmin 17 JBrowse link 1 188,034,614 188,101,590 RGD:13792537
G Syt2 synaptotagmin 2 JBrowse link 13 51,569,248 51,577,824 RGD:61762
RGD:13792537
G Syt3 synaptotagmin 3 JBrowse link 1 100,379,236 100,407,862 RGD:61762
RGD:13792537
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:61762
RGD:11535113
RGD:11535116
G Syt5 synaptotagmin 5 JBrowse link 1 72,859,806 72,867,934 RGD:61762
RGD:13792537
G Syt6 synaptotagmin 6 JBrowse link 2 206,064,181 206,119,034 RGD:61762
RGD:13792537
RGD:1624291
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:61762
G Syt8 synaptotagmin 8 JBrowse link 1 215,605,408 215,607,602 RGD:61762
G Syt9 synaptotagmin 9 JBrowse link 1 171,592,703 171,769,780 RGD:13792537
G Tmed10 transmembrane p24 trafficking protein 10 JBrowse link 6 109,169,739 109,205,004 RGD:1624291
G Tmed9 transmembrane p24 trafficking protein 9 JBrowse link 17 9,560,735 9,565,249 RGD:1624291
G Txlna taxilin alpha JBrowse link 5 147,830,514 147,846,193 RGD:1600115
G Txlnb taxilin beta JBrowse link 1 12,915,781 12,961,680 RGD:1600115
G Txlng taxilin gamma JBrowse link X 33,599,643 33,648,525 RGD:1600115
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:11535093
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:11535093
G Unc13c unc-13 homolog C JBrowse link 8 80,202,736 80,656,363 RGD:11535093
G Vamp1 vesicle-associated membrane protein 1 JBrowse link 4 157,726,941 157,733,644 RGD:13792537
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:1624291
RGD:13792537
G Vamp3 vesicle-associated membrane protein 3 JBrowse link 5 168,126,157 168,136,628 RGD:13792537
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:4892614
G Vamp8 vesicle-associated membrane protein 8 JBrowse link 4 100,250,301 100,252,756 RGD:4892614
RGD:13792537
G Vps11 VPS11 core subunit of CORVET and HOPS complexes JBrowse link 8 48,677,492 48,692,295 RGD:1624291
G Vps18 VPS18 core subunit of CORVET and HOPS complexes JBrowse link 3 111,097,352 111,108,206 RGD:1624291
G Vps33b VPS33B, late endosome and lysosome associated JBrowse link 1 142,060,955 142,083,955 RGD:730029
G Vps52 VPS52 subunit of GARP complex JBrowse link 20 5,431,997 5,441,736 RGD:1624291
RGD:13792537
G Vps54 VPS54 subunit of GARP complex JBrowse link 14 106,153,407 106,207,715 RGD:13792537
syntaxin-1 binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cplx1 complexin 1 JBrowse link 14 2,194,895 2,226,610 RGD:70701
RGD:13792537
G Cplx2 complexin 2 JBrowse link 17 10,756,871 10,828,811 RGD:70701
RGD:13792537
G Dapk1 death associated protein kinase 1 JBrowse link 17 4,297,038 4,454,941 RGD:1624291
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
G Myo5a myosin VA JBrowse link 8 82,038,966 82,156,507 RGD:1581734
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase JBrowse link 10 91,879,608 91,986,242 RGD:1624291
RGD:1600115
G Prrt2 proline-rich transmembrane protein 2 JBrowse link 1 198,451,042 198,454,998 RGD:1600115
RGD:1624291
G Rnf40 ring finger protein 40 JBrowse link 1 199,037,472 199,052,823 RGD:633892
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:8553990
RGD:8553687
G Snap25 synaptosome associated protein 25 JBrowse link 3 129,697,408 129,788,417 RGD:730202
RGD:13792537
RGD:1600115
RGD:1624291
RGD:70701
RGD:1581734
G Snph syntaphilin JBrowse link 3 147,102,394 147,143,576 RGD:1600115
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:730238
RGD:13792537
RGD:1624291
RGD:70701
G Stxbp2 syntaxin binding protein 2 JBrowse link 12 2,180,101 2,191,863 RGD:730001
RGD:13792537
RGD:1600115
RGD:1624291
G Stxbp3 syntaxin binding protein 3 JBrowse link 2 211,595,763 211,638,756 RGD:1302922
RGD:13792537
G Stxbp5 syntaxin binding protein 5 JBrowse link 1 3,858,917 4,011,684 RGD:1299498
RGD:1624291
G Sybu syntabulin JBrowse link 7 83,600,614 83,670,121 RGD:1600115
G Synpr synaptoporin JBrowse link 15 14,558,613 14,885,790 RGD:13792537
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:70701
RGD:13792537
G Sypl1 synaptophysin-like 1 JBrowse link 6 52,265,920 52,286,037 RGD:13792537
G Sypl2 synaptophysin-like 2 JBrowse link 2 211,003,046 211,017,778 RGD:13792537
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:7205652
RGD:1624291
RGD:11535116
RGD:10047386
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:11535116
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:2311135
RGD:13792537
RGD:11535093
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:11535093
RGD:13792537
G Unc13c unc-13 homolog C JBrowse link 8 80,202,736 80,656,363 RGD:11535093
RGD:13792537
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:1581734
RGD:13792537
RGD:1624291
RGD:70701
G Vamp3 vesicle-associated membrane protein 3 JBrowse link 5 168,126,157 168,136,628 RGD:4892592
RGD:13792537
syntaxin-3 binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Stxbp2 syntaxin binding protein 2 JBrowse link 12 2,180,101 2,191,863 RGD:730001
RGD:13792537
RGD:1624291
RGD:1600115
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:11535116
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:11535116
G Vps33b VPS33B, late endosome and lysosome associated JBrowse link 1 142,060,955 142,083,955 RGD:730029

Term paths to the root
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Term Annotations click to browse term
  molecular_function 20216
    binding 16745
      protein binding 14229
        SNARE binding 127
          syntaxin binding + 83
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.