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ONTOLOGY REPORT - ANNOTATIONS


Term:MAPK cascade
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Accession:GO:0000165 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
Comment:MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
Synonyms:exact_synonym: MAP kinase cascade;   MAP kinase kinase kinase cascade;   MAPK signal transduction;   MAPKKK cascade;   mitogen-activated protein kinase cascade
 narrow_synonym: ERK/MAPK cascade;   MAPKKK cascade during sporulation
 related_synonym: MAPK signaling;   MAPK signalling
 xref: Wikipedia:MAPK_cascade;   Wikipedia:Mitogen-activated_protein_kinase
 only_in_taxon: NCBITaxon:2759 ! Eukaryota


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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 130250
    signaling 46545
      signal transduction 42135
        intracellular signal transduction 18987
          MAPK cascade 6392
            ERK1 and ERK2 cascade + 2698
            ERK5 cascade + 39
            MAPK cascade involved in ascospore formation 0
            MAPK cascade involved in axon regeneration + 0
            MAPK cascade involved in innate immune response 0
            negative regulation of MAPK cascade + 1392
            pheromone response MAPK cascade + 0
            positive regulation of MAPK cascade + 4236
            regulation of MAPK cascade + 5786
            stress-activated MAPK cascade + 2109
Path 2
Term Annotations click to browse term
  biological_process 130250
    metabolic process 79327
      nitrogen compound metabolic process 66728
        organonitrogen compound metabolic process 46103
          protein metabolic process 39971
            protein modification process 28008
              cellular protein modification process 28008
                protein phosphorylation 14548
                  signal transduction by protein phosphorylation 6451
                    MAPK cascade 6392
                      ERK1 and ERK2 cascade + 2698
                      ERK5 cascade + 39
                      MAPK cascade involved in ascospore formation 0
                      MAPK cascade involved in axon regeneration + 0
                      MAPK cascade involved in innate immune response 0
                      negative regulation of MAPK cascade + 1392
                      pheromone response MAPK cascade + 0
                      positive regulation of MAPK cascade + 4236
                      regulation of MAPK cascade + 5786
                      stress-activated MAPK cascade + 2109
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.