Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:MAPK cascade
go back to main search page
Accession:GO:0000165 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
Comment:MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
Synonyms:exact_synonym: MAP kinase cascade;   MAP kinase kinase kinase cascade;   MAPK signal transduction;   MAPKKK cascade;   mitogen-activated protein kinase cascade
 narrow_synonym: ERK/MAPK cascade;   MAPKKK cascade during sporulation
 related_synonym: MAPK signaling;   MAPK signalling
 xref: MIPS_funcat:30.01.05.01.03;   Wikipedia:MAPK_cascade;   Wikipedia:Mitogen-activated_protein_kinase
 only_in_taxon: NCBITaxon:2759 ! Eukaryota


show annotations for term's descendants       view all columns           Sort by:
 
MAPK cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Artn artemin JBrowse link NW_004936474 25,252,510 25,254,221 RGD:9068941
G Sbk2 SH3 domain binding kinase family member 2 JBrowse link NW_004936886 739,863 745,971 RGD:9068941
activation of MAPK activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Drd4 dopamine receptor D4 JBrowse link NW_004936888 468,334 471,254 RGD:9068941
G Fpr1 formyl peptide receptor 1 JBrowse link NW_004937026 155,550 156,608 RGD:9068941
G Prok2 prokineticin 2 JBrowse link NW_004936603 3,299,736 3,419,539 RGD:9068941
G Sbk2 SH3 domain binding kinase family member 2 JBrowse link NW_004936886 739,863 745,971 RGD:9068941
ERK1 and ERK2 cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl11 C-C motif chemokine ligand 11 JBrowse link NW_004936538 835,436 848,907 RGD:9068941
G Mt3 metallothionein 3 JBrowse link NW_004936475 8,864,512 8,866,516 RGD:9068941
inactivation of MAPK activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dusp4 dual specificity phosphatase 4 JBrowse link NW_004936573 765,954 778,524 RGD:9068941
negative regulation of ERK1 and ERK2 cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Camk2n1 calcium/calmodulin dependent protein kinase II inhibitor 1 JBrowse link NW_004936474 6,463,691 6,466,641 RGD:9068941
G Dusp4 dual specificity phosphatase 4 JBrowse link NW_004936573 765,954 778,524 RGD:9068941
positive regulation of ERK1 and ERK2 cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alkal2 ALK and LTK ligand 2 JBrowse link NW_004936532 146,648 154,475 RGD:9068941
G Ccl11 C-C motif chemokine ligand 11 JBrowse link NW_004936538 835,436 848,907 RGD:9068941
G Ccl15 C-C motif chemokine ligand 15 JBrowse link NW_004936490 298,270 302,147 RGD:9068941
G Mif macrophage migration inhibitory factor JBrowse link NW_004936619 1,207,058 1,208,010 RGD:9068941
G Mt3 metallothionein 3 JBrowse link NW_004936475 8,864,512 8,866,516 RGD:9068941
G Pla2g2a phospholipase A2 group IIA JBrowse link NW_004936474 6,091,978 6,095,961 RGD:9068941
G Sstr4 somatostatin receptor 4 JBrowse link NW_004936620 2,575,880 2,577,761 RGD:9068941
positive regulation of ERK5 cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alkal2 ALK and LTK ligand 2 JBrowse link NW_004936532 146,648 154,475 RGD:9068941
positive regulation of JNK cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eda2r ectodysplasin A2 receptor JBrowse link NW_004936635 1,303,855 1,335,766 RGD:9068941
positive regulation of JUN kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link NW_004936740 228,377 242,318 RGD:9068941
positive regulation of MAP kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC101968601 signal transducer CD24 JBrowse link NW_004936491 16,706,745 16,707,010 RGD:9068941
G LOC101969021 somatotropin JBrowse link NW_004936541 4,524,397 4,528,234 RGD:9068941
G Mif macrophage migration inhibitory factor JBrowse link NW_004936619 1,207,058 1,208,010 RGD:9068941
regulation of MAPK cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC101968601 signal transducer CD24 JBrowse link NW_004936491 16,706,745 16,707,010 RGD:9068941
regulation of stress-activated MAPK cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Page4 PAGE family member 4 JBrowse link NW_004936721 1,347,679 1,350,598 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 327
    signaling 119
      signal transduction 111
        intracellular signal transduction 45
          MAPK cascade 19
            ERK1 and ERK2 cascade + 9
            ERK5 cascade + 1
            MAPK cascade involved in ascospore formation 0
            MAPK cascade involved in axon regeneration + 0
            MAPK cascade involved in innate immune response 0
            negative regulation of MAPK cascade + 2
            pheromone response MAPK cascade + 0
            positive regulation of MAPK cascade + 15
            regulation of MAPK cascade + 18
            stress-activated MAPK cascade + 3
Path 2
Term Annotations click to browse term
  biological_process 327
    metabolic process 218
      nitrogen compound metabolic process 197
        organonitrogen compound metabolic process 121
          protein metabolic process 101
            protein modification process 68
              cellular protein modification process 68
                protein phosphorylation 36
                  signal transduction by protein phosphorylation 19
                    MAPK cascade 19
                      ERK1 and ERK2 cascade + 9
                      ERK5 cascade + 1
                      MAPK cascade involved in ascospore formation 0
                      MAPK cascade involved in axon regeneration + 0
                      MAPK cascade involved in innate immune response 0
                      negative regulation of MAPK cascade + 2
                      pheromone response MAPK cascade + 0
                      positive regulation of MAPK cascade + 15
                      regulation of MAPK cascade + 18
                      stress-activated MAPK cascade + 3
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.