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ONTOLOGY REPORT - ANNOTATIONS


Term:cytoplasmic exosome (RNase complex)
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Accession:GO:0000177 term browser browse the term
Definition:A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Synonyms:exact_synonym: cytoplasmic exosome (ribonuclease complex);   cytoplasmic exosome multienzyme ribonuclease complex;   prokaryotic exosome multienzyme ribonuclease complex


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cytoplasmic exosome (RNase complex) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Carhsp1 calcium regulated heat stable protein 1 JBrowse link 10 7,041,510 7,055,107 RGD:1624291
RGD:1600115
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease JBrowse link 15 83,466,330 83,494,107 RGD:13792537
G Dis3l DIS3-like exosome 3'-5' exoribonuclease JBrowse link 8 69,771,211 69,807,880 RGD:1600115
RGD:13792537
RGD:1624291
G Exosc2 exosome component 2 JBrowse link 3 10,151,734 10,161,997 RGD:13792537
G Exosc3 exosome component 3 JBrowse link 5 60,866,498 60,871,734 RGD:1624291
RGD:13792537
G Exosc4 exosome component 4 JBrowse link 7 117,390,302 117,393,044 RGD:13792537
G Exosc5 exosome component 5 JBrowse link 1 82,452,104 82,461,607 RGD:13792537
G Exosc6 exosome component 6 JBrowse link 19 43,190,879 43,193,164 RGD:13792537
G Exosc7 exosome component 7 JBrowse link 8 132,204,628 132,229,968 RGD:13792537
G Exosc8 exosome component 8 JBrowse link 2 143,925,643 143,932,240 RGD:13792537
G Exosc9 exosome component 9 JBrowse link 2 123,264,679 123,275,623 RGD:13792537
G Gtpbp1 GTP binding protein 1 JBrowse link 7 120,923,274 120,947,723 RGD:8553842
mitochondrial degradosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 JBrowse link 14 113,530,470 113,561,645 RGD:1624291
G Supv3l1 Suv3 like RNA helicase JBrowse link 20 32,057,530 32,080,170 RGD:1600115
RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19951
    intracellular 13934
      exosome (RNase complex) 28
        cytoplasmic exosome (RNase complex) 14
          bacterial degradosome 0
          mitochondrial degradosome 2
Path 2
Term Annotations click to browse term
  cellular_component 19951
    protein-containing complex 5828
      catalytic complex 1451
        exoribonuclease complex 29
          exosome (RNase complex) 28
            cytoplasmic exosome (RNase complex) 14
              bacterial degradosome 0
              mitochondrial degradosome 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.