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ONTOLOGY REPORT - ANNOTATIONS


Term:exosome (RNase complex)
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Accession:GO:0000178 term browser browse the term
Definition:A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Comment:Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
Synonyms:exact_synonym: exosome (ribonucleasease complex);   exosome multienzyme ribonuclease complex


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exosome (RNase complex) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease JBrowse link 15 83,466,330 83,494,107 RGD:13792537
G Dis3l DIS3-like exosome 3'-5' exoribonuclease JBrowse link 8 69,771,211 69,807,880 RGD:13792537
G Dis3l2 DIS3-like 3'-5' exoribonuclease 2 JBrowse link 9 93,767,837 94,161,106 RGD:13792537
G Exosc1 exosome component 1 JBrowse link 1 261,169,798 261,179,865 RGD:1624291
G Exosc10 exosome component 10 JBrowse link 5 165,374,964 165,398,195 RGD:1624291
G Exosc2 exosome component 2 JBrowse link 3 10,151,734 10,161,997 RGD:13792537
RGD:1624291
G Exosc3 exosome component 3 JBrowse link 5 60,866,498 60,871,734 RGD:1624291
RGD:13792537
G Exosc4 exosome component 4 JBrowse link 7 117,390,302 117,393,044 RGD:1624291
G Exosc5 exosome component 5 JBrowse link 1 82,452,104 82,461,607 RGD:1624291
G Exosc6 exosome component 6 JBrowse link 19 43,190,879 43,193,164 RGD:1624291
G Exosc7 exosome component 7 JBrowse link 8 132,204,628 132,229,968 RGD:1624291
G Exosc8 exosome component 8 JBrowse link 2 143,925,643 143,932,240 RGD:1624291
G Exosc9 exosome component 9 JBrowse link 2 123,264,679 123,275,623 RGD:1600115
RGD:1624291
G Mphosph6 M phase phosphoprotein 6 JBrowse link 19 50,357,314 50,367,137 RGD:1624291
G Mtrex Mtr4 exosome RNA helicase JBrowse link 2 44,726,716 44,787,013 RGD:1624291
G Zfc3h1 zinc finger, C3H1-type containing JBrowse link 7 58,365,979 58,424,326 RGD:1624291
G Zfp36 zinc finger protein 36 JBrowse link 1 85,380,088 85,382,565 RGD:1624291
RGD:1600115
cytoplasmic exosome (RNase complex) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Carhsp1 calcium regulated heat stable protein 1 JBrowse link 10 7,041,510 7,055,107 RGD:1624291
RGD:1600115
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease JBrowse link 15 83,466,330 83,494,107 RGD:13792537
G Dis3l DIS3-like exosome 3'-5' exoribonuclease JBrowse link 8 69,771,211 69,807,880 RGD:1600115
RGD:13792537
RGD:1624291
G Exosc2 exosome component 2 JBrowse link 3 10,151,734 10,161,997 RGD:13792537
G Exosc3 exosome component 3 JBrowse link 5 60,866,498 60,871,734 RGD:1624291
RGD:13792537
G Exosc4 exosome component 4 JBrowse link 7 117,390,302 117,393,044 RGD:13792537
G Exosc5 exosome component 5 JBrowse link 1 82,452,104 82,461,607 RGD:13792537
G Exosc6 exosome component 6 JBrowse link 19 43,190,879 43,193,164 RGD:13792537
G Exosc7 exosome component 7 JBrowse link 8 132,204,628 132,229,968 RGD:13792537
G Exosc8 exosome component 8 JBrowse link 2 143,925,643 143,932,240 RGD:13792537
G Exosc9 exosome component 9 JBrowse link 2 123,264,679 123,275,623 RGD:13792537
G Gtpbp1 GTP binding protein 1 JBrowse link 7 120,923,274 120,947,723 RGD:8553842
mitochondrial degradosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 JBrowse link 14 113,530,470 113,561,645 RGD:1624291
G Supv3l1 Suv3 like RNA helicase JBrowse link 20 32,057,530 32,080,170 RGD:1600115
RGD:1624291
RGD:13792537
nuclear exosome (RNase complex) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07064102.1 RGD:13792537
G AABR07064998.2 RGD:13792537
G AABR07065012.1 RGD:13792537
G AABR07065013.1 RGD:13792537
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease JBrowse link 15 83,466,330 83,494,107 RGD:1624291
RGD:13792537
G Exosc1 exosome component 1 JBrowse link 1 261,169,798 261,179,865 RGD:13792537
G Exosc10 exosome component 10 JBrowse link 5 165,374,964 165,398,195 RGD:1624291
RGD:13792537
G Exosc2 exosome component 2 JBrowse link 3 10,151,734 10,161,997 RGD:1624291
RGD:13792537
G Exosc3 exosome component 3 JBrowse link 5 60,866,498 60,871,734 RGD:1624291
RGD:13792537
G Exosc4 exosome component 4 JBrowse link 7 117,390,302 117,393,044 RGD:13792537
G Exosc5 exosome component 5 JBrowse link 1 82,452,104 82,461,607 RGD:13792537
G Exosc6 exosome component 6 JBrowse link 19 43,190,879 43,193,164 RGD:13792537
G Exosc7 exosome component 7 JBrowse link 8 132,204,628 132,229,968 RGD:13792537
G Exosc8 exosome component 8 JBrowse link 2 143,925,643 143,932,240 RGD:13792537
G Exosc9 exosome component 9 JBrowse link 2 123,264,679 123,275,623 RGD:1624291
RGD:13792537
G Mphosph6 M phase phosphoprotein 6 JBrowse link 19 50,357,314 50,367,137 RGD:1624291
RGD:13792537
G Mtrex Mtr4 exosome RNA helicase JBrowse link 2 44,726,716 44,787,013 RGD:1624291
G Nvl nuclear VCP-like JBrowse link 13 99,410,026 99,468,783 RGD:1624291
G Wdr74 WD repeat domain 74 JBrowse link 1 224,933,906 224,938,659 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19809
    intracellular 13790
      exosome (RNase complex) 27
        cytoplasmic exosome (RNase complex) + 14
        nuclear exosome (RNase complex) + 19
Path 2
Term Annotations click to browse term
  cellular_component 19809
    protein-containing complex 5770
      catalytic complex 1432
        exoribonuclease complex 28
          exosome (RNase complex) 27
            cytoplasmic exosome (RNase complex) + 14
            nuclear exosome (RNase complex) + 19
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.