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ONTOLOGY REPORT - ANNOTATIONS


Term:rDNA heterochromatin assembly
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Accession:GO:0000183 term browser browse the term
Definition:The assembly of chromatin characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of rDNA.
Synonyms:exact_synonym: chromatin silencing at ribosomal DNA;   heterochromatic silencing at rDNA;   rDNA chromatin silencing
 related_synonym: chromatin silencing at rDNA


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rDNA heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baz2a bromodomain adjacent to zinc finger domain 2A ISO (MGI:MGI:3587127|PMID:16085498), (MGI:MGI:3653583|PMID:16678107), (MGI:MGI:3852313|PMID:12198165), (MGI:MGI:3852588|PMID:19578370)
(MGI:MGI:4462332|PMID:20168299)
MGI PMID:12198165, PMID:16085498, PMID:16678107, PMID:19578370, PMID:20168299 MGI:MGI:3587127, MGI:MGI:3653583, MGI:MGI:3852313, MGI:MGI:3852588, MGI:MGI:4462332 NCBI chrNW_004936646:914,944...949,057 JBrowse link
G Bend3 BEN domain containing 3 ISO (PMID:26100909) UniProtKB PMID:26100909 NCBI chrNW_004936564:3,495,020...3,513,684 JBrowse link
G Rrp8 ribosomal RNA processing 8 ISO (PMID:18485871) UniProtKB PMID:18485871 NCBI chrNW_004936842:656,508...661,894 JBrowse link
G Sirt1 sirtuin 1 ISO (PMID:18485871) UniProtKB PMID:18485871 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 ISO (MGI:MGI:3587127|PMID:16085498) UniProtKB PMID:16085498 MGI:MGI:3587127 NCBI chrNW_004936535:4,857,816...4,890,266 JBrowse link
G Suv39h1 suppressor of variegation 3-9 homolog 1 ISO (PMID:18485871) UniProtKB PMID:18485871 NCBI chrNW_004936721:646,778...661,144 JBrowse link
G Ubtf upstream binding transcription factor ISO (MGI:MGI:3836497|PMID:19103806) MGI PMID:19103806 MGI:MGI:3836497 NCBI chrNW_004936541:671,178...687,485 JBrowse link
negative regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Phf2 PHD finger protein 2 ISO (PMID:20129925) UniProtKB PMID:20129925 NCBI chrNW_004936487:2,912,114...2,956,429 JBrowse link
G Phf8 PHD finger protein 8 ISO (PMID:20208542) UniProtKB PMID:20208542 NCBI chrNW_004936751:850,630...935,382 JBrowse link
regulation of ribosomal DNA heterochromatin assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101971629 core histone macro-H2A.1 NOT ISO (PMID:24071584) UniProtKB PMID:24071584 NCBI chrNW_004936597:2,496,489...2,556,352 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11962
    cellular process 11135
      cellular component organization or biogenesis 4887
        cellular component organization 4809
          chromatin organization 543
            chromatin remodeling 117
              heterochromatin assembly 41
                rDNA heterochromatin assembly 10
                  negative regulation of ribosomal DNA heterochromatin assembly 2
                  positive regulation of rDNA heterochromatin assembly 0
                  regulation of ribosomal DNA heterochromatin assembly + 3
Path 2
Term Annotations click to browse term
  biological_process 11962
    metabolic process 7653
      cellular metabolic process 7051
        cellular aromatic compound metabolic process 3743
          nucleobase-containing compound metabolic process 3574
            nucleic acid metabolic process 3288
              RNA metabolic process 2915
                regulation of RNA metabolic process 2500
                  negative regulation of RNA metabolic process 1159
                    negative regulation of RNA biosynthetic process 1068
                      negative regulation of nucleic acid-templated transcription 1066
                        negative regulation of transcription, DNA-templated 1062
                          chromatin organization involved in negative regulation of transcription 59
                            heterochromatin assembly 41
                              rDNA heterochromatin assembly 10
                                negative regulation of ribosomal DNA heterochromatin assembly 2
                                positive regulation of rDNA heterochromatin assembly 0
                                regulation of ribosomal DNA heterochromatin assembly + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.