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Term:activation of MAPK activity
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Accession:GO:0000187 term browser browse the term
Definition:The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
Synonyms:exact_synonym: MAPK activation;   activation of MAP kinase
 narrow_synonym: activation of MAPK activity during sporulation


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activation of MAPK activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra2b adrenoceptor alpha 2B JBrowse link 3 119,805,941 119,809,987 RGD:1304238
G Alk ALK receptor tyrosine kinase JBrowse link 6 22,696,415 23,203,791 RGD:1600115
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:12790656
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:1304268
RGD:631797
G Avpi1 arginine vasopressin-induced 1 JBrowse link 1 261,365,590 261,371,519 RGD:1624291
RGD:13792537
RGD:1600115
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1600115
RGD:1624291
G C1qtnf2 C1q and TNF related 2 JBrowse link 10 29,067,102 29,084,035 RGD:1624291
RGD:1600115
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:728220
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:1624291
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:1600115
RGD:1624291
G Cspg4 chondroitin sulfate proteoglycan 4 JBrowse link 8 61,532,465 61,567,510 RGD:1600115
RGD:1624291
G Cxcl17 C-X-C motif chemokine ligand 17 JBrowse link 1 82,267,381 82,279,145 RGD:1624291
RGD:1600115
G Drd4 dopamine receptor D4 JBrowse link 1 214,278,296 214,282,818 RGD:1600115
RGD:1624291
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:1624291
G Epgn epithelial mitogen JBrowse link 14 18,627,103 18,635,135 RGD:1624291
RGD:1600115
G Erp29 endoplasmic reticulum protein 29 JBrowse link 12 40,619,377 40,625,884 RGD:1624291
RGD:1600115
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
G Fcer1a Fc fragment of IgE receptor Ia JBrowse link 13 91,727,253 91,737,106 RGD:1624291
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:1624291
RGD:1600115
G Fgf10 fibroblast growth factor 10 JBrowse link 2 51,673,480 51,747,533 RGD:1624291
RGD:1600115
G Frs2 fibroblast growth factor receptor substrate 2 JBrowse link 7 60,128,506 60,210,482 RGD:1624291
RGD:1600115
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:1624291
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:1600115
RGD:1624291
G Gfral GDNF family receptor alpha like JBrowse link 8 83,235,647 83,282,635 RGD:1600115
RGD:1624291
G Ghr growth hormone receptor JBrowse link 2 53,149,225 53,413,954 RGD:8553732
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:1624291
RGD:1600115
G Gpr39 G protein-coupled receptor 39 JBrowse link 13 42,008,642 42,220,737 RGD:1624291
G Grm1 glutamate metabotropic receptor 1 JBrowse link 1 4,753,141 5,165,859 RGD:1600115
RGD:1624291
G Grm4 glutamate metabotropic receptor 4 JBrowse link 20 6,745,682 6,791,521 RGD:1624291
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:1624291
RGD:1600115
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
RGD:1600115
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G Inava innate immunity activator JBrowse link 13 53,088,438 53,108,713 RGD:1624291
RGD:1600115
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:13792537
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
RGD:13792537
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:1624291
RGD:1600115
G Iqgap3 IQ motif containing GTPase activating protein 3 JBrowse link 2 187,447,477 187,489,630 RGD:1624291
RGD:1600115
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,127,403 47,281,387 RGD:2302385
G Kars lysyl-tRNA synthetase JBrowse link 19 44,212,205 44,231,209 RGD:1624291
RGD:13792537
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:1624291
RGD:1600115
G LOC100911248 crk-like protein-like JBrowse link 11 87,778,338 87,815,049 RGD:1600115
G Lpar1 lysophosphatidic acid receptor 1 JBrowse link 5 75,557,038 75,678,067 RGD:1624291
RGD:1600115
G Lpar2 lysophosphatidic acid receptor 2 JBrowse link 16 21,343,313 21,348,913 RGD:1624291
G Lpar3 lysophosphatidic acid receptor 3 JBrowse link 2 252,090,634 252,159,221 RGD:1624291
RGD:1600115
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:1600115
G Madd MAP-kinase activating death domain JBrowse link 3 79,960,301 80,003,023 RGD:1600115
RGD:1624291
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:2293305
RGD:13792537
RGD:1600115
RGD:1624291
RGD:8553538
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:8553538
RGD:13792537
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:1624291
RGD:13792537
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:13792537
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:8553940
RGD:13792537
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:1624291
RGD:13792537
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:1600115
RGD:13792537
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:1624291
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:724475
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:1624291
RGD:1600115
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:1624291
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:1600115
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:1600115
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:1624291
G Mos MOS proto-oncogene, serine/threonine kinase JBrowse link 5 16,746,085 16,747,392 RGD:1600115
RGD:1624291
G Muc20 mucin 20, cell surface associated JBrowse link 11 71,222,602 71,236,223 RGD:1624291
RGD:13792537
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:1600115
RGD:1624291
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:1624291
RGD:1600115
G Ntrk3 neurotrophic receptor tyrosine kinase 3 JBrowse link 1 139,890,537 140,262,503 RGD:1624291
RGD:1600115
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:1600115
G Pde6g phosphodiesterase 6G JBrowse link 10 109,620,499 109,625,214 RGD:1624291
RGD:13792537
G Pde6h phosphodiesterase 6H JBrowse link 4 170,947,723 170,963,046 RGD:1624291
RGD:13792537
G Pla2g1b phospholipase A2 group IB JBrowse link 12 46,879,346 46,890,234 RGD:1624291
G Plce1 phospholipase C, epsilon 1 JBrowse link 1 257,156,023 257,465,440 RGD:1600115
RGD:1624291
G Prdx2 peroxiredoxin 2 JBrowse link 19 26,084,816 26,090,095 RGD:1624291
RGD:1600115
G Prok1 prokineticin 1 JBrowse link 2 209,986,503 209,994,438 RGD:1624291
RGD:13792537
G Prok2 prokineticin 2 JBrowse link 4 132,157,556 132,171,244 RGD:13792537
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:1624291
RGD:1600115
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:1624291
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:1600115
RGD:1624291
G Sbk2 SH3 domain binding kinase family, member 2 JBrowse link 1 72,425,728 72,433,494 RGD:13792537
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1580336
RGD:13792537
RGD:1624291
RGD:1600115
G Shc2 SHC adaptor protein 2 JBrowse link 7 12,948,952 12,971,174 RGD:1600115
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:1624291
RGD:1600115
G Spag9 sperm associated antigen 9 JBrowse link 10 81,693,736 81,827,562 RGD:1624291
G Stk39 serine threonine kinase 39 JBrowse link 3 54,359,449 54,625,702 RGD:727300
RGD:1624291
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1624291
G Tdgf1 teratocarcinoma-derived growth factor 1 JBrowse link 8 119,215,266 119,220,909 RGD:1624291
RGD:1600115
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:1624291
RGD:13792537
RGD:1600115
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:1579859
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
RGD:1600115
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:2291838
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
activation of JUN kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:1600115
RGD:1624291
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:1298803
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1624291
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1624291
RGD:1600115
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:1624291
RGD:1600115
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:1624291
RGD:1600115
G Ern2 endoplasmic reticulum to nucleus signaling 2 JBrowse link 1 192,126,023 192,142,865 RGD:1624291
RGD:1600115
G Fcer1a Fc fragment of IgE receptor Ia JBrowse link 13 91,727,253 91,737,106 RGD:1624291
G Fgd4 FYVE, RhoGEF and PH domain containing 4 JBrowse link 11 88,699,222 88,796,677 RGD:1299389
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:1624291
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:2298577
RGD:13792537
RGD:2298708
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:2298561
RGD:1624291
RGD:13792537
RGD:2298565
RGD:2298577
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:1624291
G Map3k10 mitogen activated protein kinase kinase kinase 10 JBrowse link 1 84,473,178 84,491,689 RGD:13792537
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:1624291
RGD:13792537
G Map3k12 mitogen activated protein kinase kinase kinase 12 JBrowse link 7 144,102,275 144,120,306 RGD:1600115
RGD:1624291
RGD:13792537
G Map3k13 mitogen-activated protein kinase kinase kinase 13 JBrowse link 11 82,744,391 82,938,357 RGD:13792537
RGD:1624291
G Map3k20 mitogen-activated protein kinase kinase kinase 20 JBrowse link 3 58,965,025 59,120,507 RGD:1624291
G Map3k21 mitogen-activated protein kinase kinase kinase 21 JBrowse link 19 58,744,995 58,779,408 RGD:13792537
G Map3k9 mitogen-activated protein kinase kinase kinase 9 JBrowse link 6 105,455,461 105,518,974 RGD:13792537
G Map4k1 mitogen activated protein kinase kinase kinase kinase 1 JBrowse link 1 87,937,126 87,959,514 RGD:1600115
RGD:1624291
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 JBrowse link 1 221,710,622 221,726,274 RGD:1624291
RGD:1600115
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 10 14,259,394 14,299,276 RGD:1624291
RGD:13673827
RGD:13792537
G Mdfi MyoD family inhibitor JBrowse link 9 15,166,118 15,184,469 RGD:1624291
G Mdfic MyoD family inhibitor domain containing JBrowse link 4 42,202,546 42,282,499 RGD:1624291
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
RGD:1600115
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
RGD:1600115
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:13792537
G Spag9 sperm associated antigen 9 JBrowse link 10 81,693,736 81,827,562 RGD:1624291
RGD:13792537
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1624291
RGD:1600115
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:1624291
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1600115
RGD:1624291
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:2292645

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    cellular process 17125
      signal transduction 6837
        signal transduction by protein phosphorylation 870
          MAPK cascade 850
            positive regulation of MAPK cascade 567
              positive regulation of MAP kinase activity 237
                activation of MAPK activity 121
                  activation of JUN kinase activity 36
                  activation of MAPK activity by adrenergic receptor signaling pathway 0
                  activation of MAPK activity involved in cell wall organization or biogenesis 0
                  activation of MAPK activity involved in conjugation with cellular fusion 0
                  activation of MAPK activity involved in osmosensory signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 19245
    metabolic process 11438
      organic substance metabolic process 10836
        macromolecule metabolic process 9317
          cellular macromolecule metabolic process 8037
            cellular protein metabolic process 5268
              cellular protein modification process 3844
                regulation of protein modification process 1917
                  regulation of protein phosphorylation 1504
                    regulation of protein kinase activity 754
                      regulation of protein serine/threonine kinase activity 487
                        positive regulation of protein serine/threonine kinase activity 320
                          positive regulation of MAP kinase activity 237
                            activation of MAPK activity 121
                              activation of JUN kinase activity 36
                              activation of MAPK activity by adrenergic receptor signaling pathway 0
                              activation of MAPK activity involved in cell wall organization or biogenesis 0
                              activation of MAPK activity involved in conjugation with cellular fusion 0
                              activation of MAPK activity involved in osmosensory signaling pathway 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.