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ONTOLOGY REPORT - ANNOTATIONS


Term:mitophagy
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Accession:GO:0000423 term browser browse the term
Definition:The selective autophagy process in which a mitochondrion is degraded by macroautophagy.
Comment:Note that this terms refers to the macroautophagy process and is named by common usage. Be aware that there are a separate micromitophagy and mitophagy by induced vacuole formation processes.
Synonyms:exact_synonym: macromitophagy


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mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ambra1 autophagy and beclin 1 regulator 1 JBrowse link 3 80,634,470 80,830,068 RGD:1624291
G Atg13 autophagy related 13 JBrowse link 3 80,580,549 80,614,554 RGD:1624291
RGD:13792537
G Atg14 autophagy related 14 JBrowse link 15 24,343,418 24,374,776 RGD:1624291
RGD:13792537
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:1624291
RGD:13792537
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:1624291
negative regulation of mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
G Rnf41 ring finger protein 41 JBrowse link 7 2,827,242 2,854,230 RGD:1624291
G Tigar TP53 induced glycolysis regulatory phosphatase JBrowse link 4 159,635,145 159,654,108 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Usp30 ubiquitin specific peptidase 30 JBrowse link 12 48,262,663 48,316,580 RGD:13208875
negative regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:1624291
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vps13c vacuolar protein sorting 13 homolog C JBrowse link 8 73,682,814 73,843,290 RGD:1624291
RGD:1600115
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:1624291
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:1600115
RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:1624291
positive regulation of mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:13432560
G Vps13d vacuolar protein sorting 13 homolog D JBrowse link 5 162,891,451 163,119,239 RGD:1624291
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc37 cell division cycle 37 JBrowse link 8 22,160,922 22,173,797 RGD:1624291
RGD:1600115
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link X 21,474,627 21,603,348 RGD:1600115
RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Tomm7 translocase of outer mitochondrial membrane 7 JBrowse link 4 7,835,949 7,842,790 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19335
    cellular process 17239
      process utilizing autophagic mechanism 430
        autophagy 430
          autophagy of mitochondrion 72
            mitophagy 23
              negative regulation of mitophagy + 6
              positive regulation of mitophagy + 11
              regulation of mitophagy + 17
Path 2
Term Annotations click to browse term
  biological_process 19335
    cellular process 17239
      cellular component organization 6221
        organelle organization 3831
          organelle disassembly 98
            mitochondrion disassembly 72
              autophagy of mitochondrion 72
                mitophagy 23
                  negative regulation of mitophagy + 6
                  positive regulation of mitophagy + 11
                  regulation of mitophagy + 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.