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ONTOLOGY REPORT - ANNOTATIONS


Term:mitophagy
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Accession:GO:0000423 term browser browse the term
Definition:The selective autophagy process in which a mitochondrion is degraded by macroautophagy.
Comment:Note that this terms refers to the macroautophagy process and is named by common usage. Be aware that there are a separate micromitophagy and mitophagy by induced vacuole formation processes.
Synonyms:exact_synonym: macromitophagy


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mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AMBRA1 autophagy and beclin 1 regulator 1 JBrowse link 11 46,396,412 46,594,055 RGD:2290271
G ATG13 autophagy related 13 JBrowse link 11 46,617,276 46,676,019 RGD:2290271
G ATG14 autophagy related 14 JBrowse link 14 55,366,391 55,411,830 RGD:2290271
G BECN1 beclin 1 JBrowse link 17 42,810,132 42,824,316 RGD:2290271
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 6 161,347,417 162,727,802 RGD:2290271
G SQSTM1 sequestosome 1 JBrowse link 5 179,806,393 179,838,078 RGD:2290271
negative regulation of mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CLEC16A C-type lectin domain containing 16A JBrowse link 16 10,944,488 11,193,272 RGD:2290271
G RNF41 ring finger protein 41 JBrowse link 12 56,202,179 56,221,982 RGD:2290271
G TIGAR TP53 induced glycolysis regulatory phosphatase JBrowse link 12 4,321,213 4,360,028 RGD:2290271
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:2290271
G TSC2 TSC complex subunit 2 JBrowse link 16 2,047,804 2,089,491 RGD:2290271
G USP30 ubiquitin specific peptidase 30 JBrowse link 12 109,023,089 109,088,026 RGD:2290271
negative regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HTRA2 HtrA serine peptidase 2 JBrowse link 2 74,529,405 74,533,556 RGD:2290271
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G VPS13C vacuolar protein sorting 13 homolog C JBrowse link 15 61,852,389 62,060,465 RGD:2290271
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HDAC6 histone deacetylase 6 JBrowse link X 48,801,398 48,824,982 RGD:2290271
G MFN2 mitofusin 2 JBrowse link 1 11,980,181 12,013,515 RGD:2290271
G OPTN optineurin JBrowse link 10 13,100,082 13,138,308 RGD:2290271
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 6 161,347,417 162,727,802 RGD:2290271
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 7 99,027,435 99,144,118 RGD:2290271
positive regulation of mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G VPS13D vacuolar protein sorting 13 homolog D JBrowse link 1 12,230,030 12,512,047 RGD:2290271
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CDC37 cell division cycle 37 JBrowse link 19 10,391,128 10,403,568 RGD:2290271
G HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link X 53,532,096 53,686,723 RGD:2290271
G PINK1 PTEN induced kinase 1 JBrowse link 1 20,633,458 20,651,511 RGD:2290271
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 6 161,347,417 162,727,802 RGD:2290271
G TOMM7 translocase of outer mitochondrial membrane 7 JBrowse link 7 22,812,632 22,822,849 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17988
    cellular process 16264
      process utilizing autophagic mechanism 521
        autophagy 521
          autophagy of mitochondrion 79
            mitophagy 23
              negative regulation of mitophagy + 7
              positive regulation of mitophagy + 11
              regulation of mitophagy + 18
Path 2
Term Annotations click to browse term
  biological_process 17988
    cellular process 16264
      cellular component organization 6500
        organelle organization 4027
          organelle disassembly 104
            mitochondrion disassembly 79
              autophagy of mitochondrion 79
                mitophagy 23
                  negative regulation of mitophagy + 7
                  positive regulation of mitophagy + 11
                  regulation of mitophagy + 18
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.