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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA catabolic process, endonucleolytic
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Accession:GO:0000737 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
Synonyms:exact_synonym: DNA breakdown, endonucleolytic;   DNA degradation, endonucleolytic;   endonucleolytic DNA catabolism;   endonucleolytic degradation of DNA


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DNA catabolic process, endonucleolytic term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnase1 deoxyribonuclease 1 ISS
ISO
IBA
PMID:29191910
(MGI:6094744|PMID:29191910)
PMID:21873635
RGD PMID:29191910, PMID:29191910, PMID:21873635 MGI:6094744, RGD:13464261, RGD:13792537 NCBI chr10:11,757,681...11,760,672
Ensembl chr10:11,757,682...11,760,620
JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:156,429,521...156,438,066
Ensembl chr  X:156,429,585...156,438,066
JBrowse link
G Dnase1l2 deoxyribonuclease 1 like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,812,335...13,814,514
Ensembl chr10:13,812,707...13,814,304
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 ISS
ISO
IBA
PMID:29191910
(MGI:6094744|PMID:29191910)
PMID:21873635
RGD PMID:29191910, PMID:29191910, PMID:21873635 MGI:6094744, RGD:13464261, RGD:13792537 NCBI chr15:18,710,492...18,736,476
Ensembl chr15:18,710,492...18,736,473
JBrowse link
G Endog endonuclease G IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Exog exo/endonuclease G IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:128,133,398...128,153,110
Ensembl chr 8:128,133,431...128,153,110
JBrowse link
G Fbh1 F-box DNA helicase 1 ISO (PMID:23361013) RGD PMID:23361013 NCBI chr17:70,399,093...70,437,151
Ensembl chr17:70,399,049...70,437,144
JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit ISO (PMID:23361013) RGD PMID:23361013 NCBI chr 1:220,862,474...220,867,973
Ensembl chr 1:220,862,386...220,867,815
JBrowse link
G Rexo4 REX4 homolog, 3'-5' exonuclease ISO
IBA
(PMID:21602889)
PMID:21873635
RGD PMID:21602889, PMID:21873635 RGD:13792537 NCBI chr 3:5,500,578...5,510,908
Ensembl chr 3:5,500,589...5,510,908
JBrowse link
G Setmar SET domain and mariner transposase fusion gene ISO (PMID:20521842), (PMID:21491884), (PMID:24573677) RGD PMID:20521842, PMID:21491884, PMID:24573677 NCBI chr 4:140,092,346...140,104,495
Ensembl chr 4:140,092,352...140,105,316
JBrowse link
G Spo11 SPO11, initiator of meiotic double stranded breaks IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:170,991,573...171,008,226
Ensembl chr 3:170,994,038...171,013,185
JBrowse link
apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor subunit alpha IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dffb DNA fragmentation factor subunit beta IDA
IEA
IBA
ISO
GO_REF:0000002
PMID:21873635
(PMID:15572351), (PMID:22253444)
InterPro
RGD
PMID:15572351, PMID:22253444, PMID:11425895, PMID:21873635 GO_REF:0000002, RGD:628524, RGD:13792537 NCBI chr 5:171,250,559...171,261,875
Ensembl chr 5:171,249,633...171,262,119
JBrowse link
G Dicer1 dicer 1 ribonuclease III IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 TAS
ISO
IBA
(MGI:2385551|PMID:12050166)
PMID:21873635
(PMID:23229555)
RGD PMID:12050166, PMID:23229555, PMID:9665719, PMID:21873635 MGI:2385551, RGD:728743, RGD:13792537 NCBI chr15:18,710,492...18,736,476
Ensembl chr15:18,710,492...18,736,473
JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:26,022,855...26,025,523
Ensembl chr19:26,022,849...26,025,532
JBrowse link
G Dnase2b deoxyribonuclease 2 beta IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:252,436,363...252,475,506
Ensembl chr 2:252,436,332...252,451,999
JBrowse link
G Endog endonuclease G IBA
ISO
PMID:21873635
MGI:3034030|MGI:3514265 (MGI:3029597|PMID:14663139)
RGD PMID:14663139, PMID:21873635 MGI:3029597, RGD:13792537 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Exog exo/endonuclease G IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:128,133,398...128,153,110
Ensembl chr 8:128,133,431...128,153,110
JBrowse link
G Foxl2 forkhead box L2 ISO (PMID:16153597) RGD PMID:16153597 NCBI chr 8:107,194,492...107,197,644
Ensembl chr 8:107,194,551...107,195,675
JBrowse link
negative regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor subunit alpha ISO (PMID:15572351)
MGI:2179456 (MGI:2182584|PMID:10601318), (MGI:3029597|PMID:14663139)
RGD PMID:10601318, PMID:14663139, PMID:15572351 MGI:2182584, MGI:3029597 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 IMP RGD PMID:27184051 RGD:13781945 NCBI chr 5:166,409,460...166,430,291
Ensembl chr 5:166,409,461...166,430,254
JBrowse link
G Pam16 presequence translocase associated motor 16 IDA RGD PMID:24069394 RGD:13462066 NCBI chr10:11,146,359...11,153,936
Ensembl chr10:11,146,359...11,153,936
JBrowse link
positive regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator ISO
IEA
(PMID:11350920)
GO_REF:0000107
RGD
Ensembl
PMID:11350920 GO_REF:0000107 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Endog endonuclease G IMP RGD PMID:16407272 RGD:9685355 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Hsf1 heat shock transcription factor 1 IMP RGD PMID:21192280 RGD:10403035 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 IMP RGD PMID:15125883 RGD:10402776 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il6 interleukin 6 ISO (PMID:28433754) RGD PMID:28433754 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 ISO MGI:1306796 (MGI:3577148|PMID:15703386) RGD PMID:15703386 MGI:3577148 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 ISO MGI:1349414 (MGI:3577148|PMID:15703386) RGD PMID:15703386 MGI:3577148 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO (PMID:12082630) RGD PMID:12082630 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cidea cell death-inducing DFFA-like effector a ISO (MGI:1203887|PMID:9564035) RGD PMID:9564035 MGI:1203887 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        cellular catabolic process 2177
          cellular macromolecule catabolic process 1132
            DNA catabolic process 36
              DNA catabolic process, endonucleolytic 27
                apoptotic DNA fragmentation + 19
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        heterocycle metabolic process 5619
          nucleobase-containing compound metabolic process 5488
            nucleic acid metabolic process 4984
              DNA metabolic process 923
                DNA catabolic process 36
                  DNA catabolic process, endonucleolytic 27
                    apoptotic DNA fragmentation + 19
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.