ONTOLOGY REPORT - ANNOTATIONS


Term:syncytium formation by plasma membrane fusion
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Accession:GO:0000768 term browser browse the term
Definition:The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
Synonyms:broad_synonym: cell fusion


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syncytium formation by plasma membrane fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ervfrd-1 endogenous retrovirus group FRD member 1, envelope JBrowse link 12 25,161,130 25,168,182 RGD:1624291
RGD:1600115
G Synb syncytin b JBrowse link 15 51,174,986 51,222,929 RGD:1624291
G Vash2 vasohibin 2 JBrowse link 13 109,521,190 109,552,607 RGD:1624291
macrophage fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:2289375
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrb3 adhesion G protein-coupled receptor B3 JBrowse link 9 31,280,623 32,022,535 RGD:1624291
RGD:1600115
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:1624291
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:1624291
RGD:1600115
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:1298731
G Cast calpastatin JBrowse link 2 1,452,111 1,561,669 RGD:1298731
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
RGD:1600115
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:1624291
RGD:1600115
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B JBrowse link 1 85,112,819 85,120,840 RGD:1624291
RGD:1600115
G Fer1l5 fer-1-like family member 5 JBrowse link 9 42,943,362 42,998,126 RGD:1600115
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
RGD:1600115
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:1624291
G Mymk myomaker, myoblast fusion factor JBrowse link 3 5,608,243 5,617,689 RGD:1624291
G Mymx myomixer, myoblast fusion factor JBrowse link 9 17,781,397 17,783,074 RGD:1624291
RGD:13792537
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:1624291
RGD:1600115
G Myof myoferlin JBrowse link 1 256,585,410 256,734,727 RGD:1600115
G Neo1 neogenin 1 JBrowse link 8 63,649,871 63,756,394 RGD:1624291
G Nphs1 NPHS1 adhesion molecule, nephrin JBrowse link 1 88,922,346 88,950,560 RGD:1600115
RGD:1624291
G Pitx2 paired-like homeodomain 2 JBrowse link 2 233,602,732 233,621,059 RGD:1624291
G Plekho1 pleckstrin homology domain containing O1 JBrowse link 2 198,112,104 198,120,202 RGD:1624291
RGD:1600115
G Tanc1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 JBrowse link 3 45,683,773 45,917,687 RGD:1624291
RGD:1600115
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
RGD:1600115
myoblast fusion involved in skeletal muscle regeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Cd9 CD9 molecule JBrowse link 4 157,977,163 158,010,091 RGD:1600115
RGD:1624291
G Mymk myomaker, myoblast fusion factor JBrowse link 3 5,608,243 5,617,689 RGD:1624291
G Mymx myomixer, myoblast fusion factor JBrowse link 9 17,781,397 17,783,074 RGD:1624291
G Ptgfrn prostaglandin F2 receptor inhibitor JBrowse link 2 203,423,143 203,494,391 RGD:1600115
RGD:1624291
negative regulation of macrophage fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:1624291
negative regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:1624291
RGD:1600115
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:1624291
G Il36g interleukin 36, gamma JBrowse link 3 1,285,658 1,291,836 RGD:1624291
negative regulation of syncytium formation by plasma membrane fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nfe2 nuclear factor, erythroid 2 JBrowse link 7 144,872,739 144,880,092 RGD:1624291
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:1624291
RGD:1600115
osteoclast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd109 CD109 molecule JBrowse link 8 85,951,420 86,065,411 RGD:1624291
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Dcstamp dendrocyte expressed seven transmembrane protein JBrowse link 7 78,642,016 78,651,763 RGD:1624291
G Sbno2 strawberry notch homolog 2 JBrowse link 7 12,471,805 12,515,700 RGD:1624291
RGD:1600115
G Sh3pxd2a SH3 and PX domains 2A JBrowse link 1 267,039,654 267,245,868 RGD:1624291
RGD:1600115
G Tcta T-cell leukemia translocation altered JBrowse link 8 117,079,094 117,082,338 RGD:1624291
RGD:13792537
positive regulation of macrophage fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam9 ADAM metallopeptidase domain 9 JBrowse link 16 71,810,377 71,887,926 RGD:1624291
RGD:1600115
G Dcstamp dendrocyte expressed seven transmembrane protein JBrowse link 7 78,642,016 78,651,763 RGD:1624291
G Ocstamp osteoclast stimulatory transmembrane protein JBrowse link 3 162,073,573 162,080,487 RGD:1624291
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
G Tyrobp Tyro protein tyrosine kinase binding protein JBrowse link 1 88,875,370 88,879,305 RGD:1600115
RGD:1624291
positive regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link 7 115,766,484 115,828,514 RGD:1624291
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:13792659
G Cd53 Cd53 molecule JBrowse link 2 209,489,279 209,537,098 RGD:1624291
RGD:1600115
G Cxcl12 C-X-C motif chemokine ligand 12 JBrowse link 4 149,261,044 149,273,891 RGD:1624291
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:1624291
RGD:1600115
G Ehd1 EH-domain containing 1 JBrowse link 1 221,644,867 221,667,242 RGD:1624291
RGD:1600115
G Ehd2 EH-domain containing 2 JBrowse link 1 77,847,599 77,865,870 RGD:1624291
RGD:1600115
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:1624291
RGD:1600115
G Flt3lg fms-related tyrosine kinase 3 ligand JBrowse link 1 101,126,006 101,131,413 RGD:1624291
RGD:1600115
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:1624291
RGD:1600115
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:1624291
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:1600115
RGD:1624291
G Myf5 myogenic factor 5 JBrowse link 7 49,729,533 49,732,974 RGD:13792537
G Myf6 myogenic factor 6 JBrowse link 7 49,739,643 49,741,490 RGD:13792537
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:1624291
RGD:13792537
RGD:1600115
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:13792537
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:1624291
RGD:1600115
G Ripor2 RHO family interacting cell polarization regulator 2 JBrowse link 17 42,324,594 42,549,907 RGD:1624291
RGD:1600115
G Scgb3a1 secretoglobin, family 3A, member 1 JBrowse link 10 35,133,561 35,134,868 RGD:1624291
RGD:13792537
G Tnfsf14 TNF superfamily member 14 JBrowse link 9 9,761,363 9,765,461 RGD:1624291
RGD:1600115
positive regulation of syncytium formation by plasma membrane fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Camk1 calcium/calmodulin-dependent protein kinase I JBrowse link 4 145,289,300 145,300,146 RGD:1624291
RGD:1600115
G Gcm1 glial cells missing transcription factor 1 JBrowse link 8 85,355,766 85,369,002 RGD:1624291
RGD:1600115
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:1624291
RGD:1600115
regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17928
    cellular process 16079
      syncytium formation 67
        syncytium formation by plasma membrane fusion 65
          macrophage fusion + 8
          myoblast fusion + 47
          negative regulation of syncytium formation by plasma membrane fusion + 6
          osteoclast fusion 6
          positive regulation of syncytium formation by plasma membrane fusion + 29
          regulation of syncytium formation by plasma membrane fusion + 34
Path 2
Term Annotations click to browse term
  biological_process 17928
    developmental process 6340
      anatomical structure development 5947
        anatomical structure morphogenesis 2746
          anatomical structure formation involved in morphogenesis 1167
            syncytium formation 67
              syncytium formation by plasma membrane fusion 65
                macrophage fusion + 8
                myoblast fusion + 47
                negative regulation of syncytium formation by plasma membrane fusion + 6
                osteoclast fusion 6
                positive regulation of syncytium formation by plasma membrane fusion + 29
                regulation of syncytium formation by plasma membrane fusion + 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.