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ONTOLOGY REPORT - ANNOTATIONS


Term:Hrd1p ubiquitin ligase complex
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Accession:GO:0000836 term browser browse the term
Definition:A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).
Synonyms:related_synonym: HRD1 ubiquitin ligase complex


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Hrd1p ubiquitin ligase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Syvn1 synoviolin 1 JBrowse link 1 221,409,281 221,416,229 RGD:13792537
Hrd1p ubiquitin ligase ERAD-L complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor JBrowse link 4 113,887,030 113,890,103 RGD:13792537
G Derl1 derlin 1 JBrowse link 7 97,737,176 97,759,852 RGD:13792537
G Derl2 derlin 2 JBrowse link 10 57,641,682 57,653,554 RGD:13792537
G Derl3 derlin 3 JBrowse link 20 13,692,102 13,707,645 RGD:13792537
G LOC103694875 derlin-3 RGD:13792537
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link 6 115,572,683 115,616,904 RGD:1600115
RGD:13792537
RGD:1624291
G Sel1l2 SEL1L2 adaptor subunit of ERAD E3 ligase JBrowse link 3 134,281,809 134,406,560 RGD:13792537
G Syvn1 synoviolin 1 JBrowse link 1 221,409,281 221,416,229 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19949
    protein-containing complex 5829
      membrane protein complex 1228
        ER ubiquitin ligase complex 8
          Hrd1p ubiquitin ligase complex 8
            Hrd1p ubiquitin ligase ERAD-L complex 8
            Hrd1p ubiquitin ligase ERAD-M complex 0
Path 2
Term Annotations click to browse term
  cellular_component 19949
    protein-containing complex 5829
      catalytic complex 1451
        transferase complex 810
          ubiquitin ligase complex 304
            cytoplasmic ubiquitin ligase complex 23
              ER ubiquitin ligase complex 8
                Hrd1p ubiquitin ligase complex 8
                  Hrd1p ubiquitin ligase ERAD-L complex 8
                  Hrd1p ubiquitin ligase ERAD-M complex 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.