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Term:Prp19 complex
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Accession:GO:0000974 term browser browse the term
Definition:A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
Synonyms:narrow_synonym: Prp19/CDC5 complex;   nineteen complex
 related_synonym: NTC

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Prp19 complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcas2 BCAS2, pre-mRNA processing factor JBrowse link 2 205,662,633 205,670,514 RGD:13792537
G Cdc5l cell division cycle 5-like JBrowse link 9 17,949,764 17,988,514 RGD:1624291
G Crnkl1 crooked neck pre-mRNA splicing factor 1 JBrowse link 6 18,349,226 18,351,540 RGD:13792537
G Ctnnbl1 catenin, beta like 1 JBrowse link 3 154,212,245 154,373,170 RGD:1624291
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:1624291
G Isy1 ISY1 splicing factor homolog JBrowse link 4 119,721,659 119,742,349 RGD:13792537
G LOC102548514 crooked neck-like protein 1-like JBrowse link 3 140,125,232 140,141,730 RGD:13792537
G Plrg1 pleiotropic regulator 1 JBrowse link 2 182,040,338 182,056,669 RGD:13792537
G Polr2a RNA polymerase II subunit A JBrowse link 10 56,339,277 56,364,888 RGD:1624291
G Prpf19 pre-mRNA processing factor 19 JBrowse link 1 226,947,065 226,958,147 RGD:1624291
G Rbm22 RNA binding motif protein 22 JBrowse link 18 55,828,158 55,839,421 RGD:13792537
G Syf2 SYF2 pre-mRNA-splicing factor JBrowse link 5 153,269,638 153,277,562 RGD:13792537
G U2af2 U2 small nuclear RNA auxiliary factor 2 JBrowse link 1 72,312,260 72,329,828 RGD:1624291
G Xab2 XPA binding protein 2 JBrowse link 12 2,158,391 2,170,397 RGD:13792537

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  cellular_component 19843
    protein-containing complex 5779
      Prp19 complex 14
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.