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ONTOLOGY REPORT - ANNOTATIONS


Term:response to acid chemical
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Accession:GO:0001101 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
Comment:This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.
Synonyms:broad_synonym: response to acid
 related_synonym: response to acid anion;   response to oxoanion


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cellular response to amino acid stimulus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL2L1 BCL2 like 1 JBrowse link 24 21,145,214 21,209,425 RGD:13508589
G CAPN2 calpain 2 JBrowse link 7 40,333,379 40,367,158 RGD:13508589
G CEBPB CCAAT enhancer binding protein beta JBrowse link 24 36,661,294 36,663,162 RGD:13508589
G COL1A1 collagen type I alpha 1 chain JBrowse link 9 26,183,852 26,199,927 RGD:13508589
G COL1A2 collagen type I alpha 2 chain JBrowse link 14 19,883,731 19,919,527 RGD:13508589
G COL3A1 collagen type III alpha 1 chain JBrowse link 36 30,488,250 30,526,367 RGD:13508589
G COL4A1 collagen type IV alpha 1 chain JBrowse link 22 58,511,210 58,651,949 RGD:13508589
G COL4A6 collagen type IV alpha 6 chain JBrowse link X 81,690,047 81,981,005 RGD:13508589
G COL5A2 collagen type V alpha 2 chain JBrowse link 36 30,538,863 30,677,450 RGD:13508589
G DNMT1 DNA methyltransferase 1 JBrowse link 20 50,872,213 50,928,352 RGD:13508589
G DNMT3A DNA methyltransferase 3 alpha JBrowse link 17 19,489,524 19,563,074 RGD:13508589
G EGFR epidermal growth factor receptor JBrowse link 18 5,983,669 6,044,092 RGD:13508589
G GLRA1 glycine receptor alpha 1 JBrowse link 4 57,443,094 57,541,494 RGD:13508589
G GLRA2 glycine receptor alpha 2 JBrowse link X 10,859,699 11,033,386 RGD:13508589
G IPO5 importin 5 JBrowse link 22 48,126,053 48,182,897 RGD:13508589
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 JBrowse link 21 25,981,170 25,986,942 RGD:13508589
G LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 JBrowse link 7 41,760,632 41,764,926 RGD:13508589
G LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 JBrowse link 32 21,820,853 21,834,443 RGD:13508589
G LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 JBrowse link 6 9,372,728 9,376,047 RGD:13508589
G LOC102156380 ragulator complex protein LAMTOR5 pseudogene JBrowse link 9 53,420,574 53,421,161 RGD:13508589
G MMP2 matrix metallopeptidase 2 JBrowse link 2 60,471,092 60,492,991 RGD:13508589
G PDGFC platelet derived growth factor C JBrowse link 15 54,143,637 54,239,962 RGD:13508589
G RPTOR regulatory associated protein of MTOR complex 1 JBrowse link 9 1,012,512 1,345,872 RGD:13508589
G RRAGB Ras related GTP binding B JBrowse link X 47,323,427 47,361,551 RGD:13508589
G RRAGC Ras related GTP binding C JBrowse link 15 3,875,193 3,892,501 RGD:13508589
G RRAGD Ras related GTP binding D JBrowse link 12 48,583,350 48,625,032 RGD:13508589
G SESN1 sestrin 1 JBrowse link 12 65,958,995 66,057,369 RGD:13508589
G SESN2 sestrin 2 JBrowse link 2 72,151,464 72,168,861 RGD:13508589
G SESN3 sestrin 3 JBrowse link 21 5,827,957 5,899,540 RGD:13508589
G SH3BP4 SH3 domain binding protein 4 JBrowse link 25 46,049,631 46,133,065 RGD:13508589
G SLC38A9 solute carrier family 38 member 9 JBrowse link 2 42,921,906 43,004,265 RGD:13508589
G SOCS1 suppressor of cytokine signaling 1 JBrowse link 6 31,511,003 31,511,995 RGD:13508589
G TNF tumor necrosis factor JBrowse link 12 1,074,561 1,076,425 RGD:13508589
cellular response to bile acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB4 ATP binding cassette subfamily B member 4 JBrowse link 14 13,542,610 13,614,334 RGD:13508589
cellular response to fatty acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FFAR2 free fatty acid receptor 2 JBrowse link 1 117,197,535 117,201,613 RGD:13508589
G KCNK4 potassium two pore domain channel subfamily K member 4 JBrowse link 18 52,767,151 52,775,053 RGD:13508589
G LPL lipoprotein lipase JBrowse link 25 37,078,306 37,102,729 RGD:13508589
G NR1H4 nuclear receptor subfamily 1 group H member 4 JBrowse link 15 39,497,313 39,608,120 RGD:13508589
G PDK3 pyruvate dehydrogenase kinase 3 JBrowse link X 19,994,383 20,058,979 RGD:13508589
G PDK4 pyruvate dehydrogenase kinase 4 JBrowse link 14 20,825,861 20,839,290 RGD:13508589
G UCP1 uncoupling protein 1 JBrowse link 19 2,254,881 2,289,902 RGD:13508589
cellular response to folic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOLR1 folate receptor alpha JBrowse link 21 25,944,350 25,951,010 RGD:13508589
G FOLR2 folate receptor beta JBrowse link 21 25,917,476 25,923,267 RGD:13508589
cellular response to hydrogen sulfide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KDR kinase insert domain receptor JBrowse link 13 47,442,861 47,484,574 RGD:13508589
cellular response to hydrostatic pressure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PKD2 polycystin 2, transient receptor potential cation channel JBrowse link 32 11,383,441 11,437,603 RGD:13508589
cellular response to L-arginine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 JBrowse link 26 23,439,472 23,443,950 RGD:13508589
G CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 JBrowse link 6 5,565,723 5,602,799 RGD:13508589
cellular response to leptomycin B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ID3 inhibitor of DNA binding 3, HLH protein JBrowse link 2 75,880,659 75,881,786 RGD:13508589
cellular response to leucine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KLHL22 kelch like family member 22 JBrowse link 26 30,248,253 30,281,989 RGD:13508589
G MTOR mechanistic target of rapamycin kinase JBrowse link 2 84,818,893 84,939,283 RGD:13508589
G RPTOR regulatory associated protein of MTOR complex 1 JBrowse link 9 1,012,512 1,345,872 RGD:13508589
G RRAGD Ras related GTP binding D JBrowse link 12 48,583,350 48,625,032 RGD:13508589
G SESN1 sestrin 1 JBrowse link 12 65,958,995 66,057,369 RGD:13508589
G SESN2 sestrin 2 JBrowse link 2 72,151,464 72,168,861 RGD:13508589
G SESN3 sestrin 3 JBrowse link 21 5,827,957 5,899,540 RGD:13508589
G UBR2 ubiquitin protein ligase E3 component n-recognin 2 JBrowse link 12 11,167,286 11,296,817 RGD:13508589
cellular response to mycophenolic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PDGFB platelet derived growth factor subunit B JBrowse link 10 25,798,877 25,819,422 RGD:13508589
cellular response to oleic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DGAT2 diacylglycerol O-acyltransferase 2 JBrowse link 21 22,833,659 22,850,300 RGD:13508589
cellular response to prostaglandin D stimulus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PTGDR prostaglandin D2 receptor JBrowse link 8 28,480,446 28,491,331 RGD:13508589
G PTGFR prostaglandin F receptor JBrowse link 6 68,460,107 68,498,793 RGD:13508589
cellular response to prostaglandin E stimulus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACACA acetyl-CoA carboxylase alpha JBrowse link 9 36,904,204 37,188,096 RGD:13508589
G ADCY6 adenylate cyclase 6 JBrowse link 27 5,739,514 5,752,888 RGD:13508589
G AKAP8 A-kinase anchoring protein 8 JBrowse link 20 46,800,917 46,817,397 RGD:13508589
G AKT1 AKT serine/threonine kinase 1 JBrowse link 8 72,317,399 72,335,686 RGD:13508589
G P2RY6 pyrimidinergic receptor P2Y6 JBrowse link 21 24,929,502 24,966,857 RGD:13508589
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 52,809,792 52,855,072 RGD:13508589
G PTGER2 prostaglandin E receptor 2 JBrowse link 8 28,523,318 28,536,936 RGD:13508589
G PTGER4 prostaglandin E receptor 4 JBrowse link 4 68,663,362 68,676,241 RGD:13508589
G TNFSF4 TNF superfamily member 4 JBrowse link 7 25,883,297 25,909,608 RGD:13508589
cellular response to retinoic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADNP2 ADNP homeobox 2 JBrowse link 1 600,804 635,013 RGD:13508589
G AQP1 aquaporin 1 (Colton blood group) JBrowse link 14 43,592,266 43,603,903 RGD:13508589
G ATM ATM serine/threonine kinase JBrowse link 5 24,180,129 24,297,207 RGD:13508589
G BRINP1 BMP/retinoic acid inducible neural specific 1 JBrowse link 11 72,625,011 72,794,641 RGD:13508589
G BRINP2 BMP/retinoic acid inducible neural specific 2 JBrowse link 7 22,332,465 22,449,295 RGD:13508589
G BRINP3 BMP/retinoic acid inducible neural specific 3 JBrowse link 38 8,181,227 8,558,518 RGD:13508589
G CREB1 cAMP responsive element binding protein 1 JBrowse link 37 15,921,214 15,978,492 RGD:13508589
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 JBrowse link 17 50,633,397 50,653,882 RGD:13508589
G HOXA2 homeobox A2 JBrowse link 14 40,273,992 40,276,975 RGD:13508589
G HTRA2 HtrA serine peptidase 2 JBrowse link 17 48,610,408 48,613,399 RGD:13508589
G NDUFA13 NADH:ubiquinone oxidoreductase subunit A13 JBrowse link 20 43,721,568 43,730,607 RGD:13508589
G OSR1 odd-skipped related transcription factor 1 JBrowse link 17 14,508,543 14,515,657 RGD:13508589
G PTK7 protein tyrosine kinase 7 (inactive) JBrowse link 12 11,593,017 11,657,149 RGD:13508589
G RARA retinoic acid receptor alpha JBrowse link 9 22,254,803 22,298,614 RGD:13508589
G RARB retinoic acid receptor beta JBrowse link 23 18,207,253 18,931,128 RGD:13508589
G RARG retinoic acid receptor gamma JBrowse link 27 1,958,432 1,978,471 RGD:13508589
G SETX senataxin JBrowse link 9 51,900,004 51,980,694 RGD:13508589
G STRA8 stimulated by retinoic acid 8 JBrowse link 16 12,929,110 12,952,468 RGD:13508589
G TEAD2 TEA domain transcription factor 2 JBrowse link 1 107,115,014 107,130,563 RGD:13508589
G TWF2 twinfilin actin binding protein 2 JBrowse link 20 37,529,322 37,539,955 RGD:13508589
G YAP1 Yes associated protein 1 JBrowse link 5 29,394,760 29,495,977 RGD:13508589
cellular response to tetrahydrofolate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SHMT1 serine hydroxymethyltransferase 1 JBrowse link 5 41,221,531 41,248,653 RGD:13508589
G SHMT2 serine hydroxymethyltransferase 2 JBrowse link 10 1,357,347 1,362,511 RGD:13508589
cellular response to water deprivation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AQP2 aquaporin 2 JBrowse link 27 4,743,127 4,750,907 RGD:13508589
response to amino acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GLRA1 glycine receptor alpha 1 JBrowse link 4 57,443,094 57,541,494 RGD:13508589
G GLRA2 glycine receptor alpha 2 JBrowse link X 10,859,699 11,033,386 RGD:13508589
G GLRA3 glycine receptor alpha 3 JBrowse link 25 25,098,280 25,305,511 RGD:13508589
G GLRA4 glycine receptor alpha 4 (pseudogene) JBrowse link X 77,115,962 77,142,381 RGD:13508589
G GLRB glycine receptor beta JBrowse link 15 54,429,131 54,519,844 RGD:13508589
G GPRC6A G protein-coupled receptor class C group 6 member A JBrowse link 1 57,191,210 57,212,008 RGD:13508589
response to biotin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HLCS holocarboxylase synthetase JBrowse link 31 31,934,796 32,159,866 RGD:13508589
response to fatty acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SCD stearoyl-CoA desaturase JBrowse link 28 13,112,741 13,129,129 RGD:13508589
response to folic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CBS cystathionine beta-synthase JBrowse link 31 37,230,900 37,247,170 RGD:13508589
response to glycine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 9 48,492,967 48,513,981 RGD:13508589
response to L-arginine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G INS insulin JBrowse link 18 46,324,047 46,324,933 RGD:13508589
response to L-glutamate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TMBIM6 transmembrane BAX inhibitor motif containing 6 JBrowse link 27 4,921,606 4,944,830 RGD:13508589
G UFL1 UFM1 specific ligase 1 JBrowse link 12 54,988,200 55,023,414 RGD:13508589
response to linoleic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD36 CD36 molecule JBrowse link 18 20,299,808 20,375,856 RGD:13508589
response to prostaglandin E term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCL19 C-C motif chemokine ligand 19 JBrowse link 11 51,357,706 51,359,207 RGD:13508589
G TGFBR3 transforming growth factor beta receptor 3 JBrowse link 6 57,025,096 57,220,240 RGD:13508589
response to retinoic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ASCL1 achaete-scute family bHLH transcription factor 1 JBrowse link 15 41,694,021 41,696,933 RGD:13508589
G CLK2 CDC like kinase 2 JBrowse link 7 42,284,869 42,294,434 RGD:13508589
G CTSH cathepsin H JBrowse link 3 58,103,284 58,113,958 RGD:13508589
G DKK1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 26 35,697,428 35,701,596 RGD:13508589
G GDAP1 ganglioside induced differentiation associated protein 1 JBrowse link 29 22,805,468 22,835,909 RGD:13508589
G GDAP2 ganglioside induced differentiation associated protein 2 JBrowse link 17 55,143,495 55,225,016 RGD:13508589
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 JBrowse link 5 69,927,888 70,009,306 RGD:13508589
G OVCA2 OVCA2 serine hydrolase domain containing JBrowse link 9 46,147,058 46,148,533 RGD:13508589
G POU5F1 POU class 5 homeobox 1 JBrowse link 12 860,702 866,099 RGD:13508589
G PPARG peroxisome proliferator activated receptor gamma JBrowse link 20 6,134,618 6,265,481 RGD:13508589
G RARA retinoic acid receptor alpha JBrowse link 9 22,254,803 22,298,614 RGD:13508589
G RARB retinoic acid receptor beta JBrowse link 23 18,207,253 18,931,128 RGD:13508589
G RARG retinoic acid receptor gamma JBrowse link 27 1,958,432 1,978,471 RGD:13508589
G RXRA retinoid X receptor alpha JBrowse link 9 50,525,195 50,575,720 RGD:13508589
G RXRB retinoid X receptor beta JBrowse link 12 2,657,058 2,663,648 RGD:13508589
G RXRG retinoid X receptor gamma JBrowse link 38 17,867,123 17,912,328 RGD:13508589
G SLC10A3 solute carrier family 10 member 3 JBrowse link X 122,197,049 122,201,103 RGD:13508589
G TIE1 tyrosine kinase with immunoglobulin like and EGF like domains 1 JBrowse link 15 16,838,267 16,857,004 RGD:13508589
G TRIML2 tripartite motif family like 2 JBrowse link 16 42,984,204 43,000,037 RGD:13508589
response to water term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PKD2L1 polycystin 2 like 1, transient receptor potential cation channel JBrowse link 28 13,045,749 13,076,072 RGD:13508589

Term paths to the root
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Term Annotations click to browse term
  biological_process 13038
    response to stimulus 5574
      response to chemical 2691
        response to acid chemical 119
          cellular response to acid chemical + 88
          response to GW 7647 + 0
          response to L-ascorbic acid + 0
          response to abscisic acid + 0
          response to acetate + 0
          response to acetylsalicylate 0
          response to amino acid + 46
          response to arsenite(3-) + 0
          response to benzoic acid + 0
          response to bile acid + 1
          response to biotin + 1
          response to butan-1-ol + 0
          response to candesartan 0
          response to chlorate + 0
          response to chondroitin 4'-sulfate + 0
          response to chondroitin 6'-sulfate + 0
          response to cyanide + 0
          response to fatty acid + 24
          response to fluoride + 0
          response to folic acid + 3
          response to formic acid + 0
          response to gibberellin + 0
          response to hydrogen sulfide + 1
          response to hypochlorite 0
          response to indolebutyric acid + 0
          response to jasmonic acid + 0
          response to methanol + 0
          response to methotrexate + 0
          response to mycophenolic acid + 1
          response to nitrate + 0
          response to nitrite + 0
          response to ozone + 0
          response to propan-1-ol + 0
          response to retinoic acid + 37
          response to salicylic acid + 0
          response to tetrahydrofolate + 2
          response to water + 3
          stress response to acid chemical + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.