ONTOLOGY REPORT - ANNOTATIONS


Term:formation of primary germ layer
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Accession:GO:0001704 term browser browse the term
Definition:The formation of the ectoderm, mesoderm and endoderm during gastrulation.


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formation of primary germ layer term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arid1a AT-rich interaction domain 1A JBrowse link 5 151,904,687 151,977,973 RGD:1624291
RGD:1600115
G Atoh8 atonal bHLH transcription factor 8 JBrowse link 4 100,067,341 100,099,517 RGD:1624291
RGD:1600115
G Kif16b kinesin family member 16B JBrowse link 3 136,596,621 136,936,809 RGD:1624291
RGD:1600115
axial mesoderm formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Axin1 axin 1 RGD:1624291
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1624291
RGD:1600115
axial mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:1624291
RGD:1600115
BMP signaling pathway involved in mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Etv2 ets variant 2 JBrowse link 1 89,091,239 89,094,570 RGD:1624291
RGD:1600115
cell fate commitment involved in formation of primary germ layer term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
ectoderm formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxa2 forkhead box A2 JBrowse link 3 142,383,084 142,387,493 RGD:1624291
G Lhx1 LIM homeobox 1 JBrowse link 10 71,843,991 71,849,293 RGD:1624291
RGD:1600115
ectodermal cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Elf5 E74 like ETS transcription factor 5 JBrowse link 3 93,333,514 93,374,454 RGD:1624291
RGD:1600115
G Ets2 ETS proto-oncogene 2, transcription factor JBrowse link 11 36,075,709 36,092,495 RGD:1624291
RGD:1600115
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
RGD:1600115
endoderm formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Eomes eomesodermin JBrowse link 8 127,144,367 127,152,618 RGD:1624291
G Gata4 GATA binding protein 4 JBrowse link 15 46,386,703 46,458,679 RGD:1624291
G Lhx1 LIM homeobox 1 JBrowse link 10 71,843,991 71,849,293 RGD:1624291
RGD:1600115
G Mixl1 Mix paired-like homeobox 1 JBrowse link 13 97,278,258 97,282,299 RGD:1624291
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:1624291
RGD:1600115
G Sox17 SRY box 17 JBrowse link 5 14,890,318 14,895,907 RGD:1624291
G Sox7 SRY box 7 JBrowse link 15 47,293,699 47,300,460 RGD:1624291
G Tnrc6c trinucleotide repeat containing adaptor 6C JBrowse link 10 106,698,359 106,763,639 RGD:1624291
endodermal cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col11a1 collagen type XI alpha 1 chain JBrowse link 2 216,863,423 217,056,523 RGD:1624291
RGD:1600115
G Col12a1 collagen type XII alpha 1 chain JBrowse link 8 87,042,820 87,150,701 RGD:1600115
RGD:1624291
G Col4a2 collagen type IV alpha 2 chain JBrowse link 16 83,386,388 83,522,169 RGD:1624291
RGD:1600115
G Col6a1 collagen type VI alpha 1 chain JBrowse link 20 12,657,913 12,676,370 RGD:1624291
RGD:1600115
G Col7a1 collagen type VII alpha 1 chain JBrowse link 8 117,694,441 117,726,844 RGD:1624291
G Col8a1 collagen type VIII alpha 1 chain JBrowse link 11 44,877,690 45,006,203 RGD:1624291
RGD:1600115
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:1600115
RGD:1624291
G Gata6 GATA binding protein 6 JBrowse link 18 2,415,821 2,447,087 RGD:1624291
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
RGD:1600115
G Hsbp1 heat shock factor binding protein 1 JBrowse link 19 51,985,196 51,989,528 RGD:1624291
RGD:1600115
G Inhba inhibin subunit beta A JBrowse link 17 51,894,869 51,919,998 RGD:1624291
RGD:1600115
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:1624291
RGD:1600115
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1624291
RGD:1600115
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,079 3,383,886 RGD:1600115
RGD:1624291
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:1624291
RGD:1600115
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:1624291
RGD:1600115
G Itgb5 integrin subunit beta 5 JBrowse link 11 70,056,500 70,172,164 RGD:1624291
G Lama3 laminin subunit alpha 3 JBrowse link 18 3,704,866 3,941,215 RGD:1624291
G Lamb1 laminin subunit beta 1 JBrowse link 6 50,528,796 50,596,593 RGD:1624291
RGD:1600115
G Lamb3 laminin subunit beta 3 JBrowse link 13 112,031,614 112,073,187 RGD:1624291
RGD:1600115
G Mixl1 Mix paired-like homeobox 1 JBrowse link 13 97,278,258 97,282,299 RGD:1624291
G Mmp14 matrix metallopeptidase 14 JBrowse link 15 33,074,441 33,083,666 RGD:1624291
RGD:1600115
G Mmp15 matrix metallopeptidase 15 JBrowse link 19 10,079,881 10,101,380 RGD:1624291
RGD:1600115
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:1600115
RGD:1624291
G Mmp8 matrix metallopeptidase 8 JBrowse link 8 5,768,808 5,777,741 RGD:1600115
RGD:1624291
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:1600115
RGD:1624291
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:1624291
RGD:1600115
G Setd2 SET domain containing 2, histone lysine methyltransferase JBrowse link 8 118,802,478 118,888,224 RGD:1624291
RGD:1600115
G Vtn vitronectin JBrowse link 10 65,767,960 65,771,040 RGD:1624291
RGD:1600115
endodermal cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc73 cell division cycle 73 JBrowse link 13 60,403,771 60,496,511 RGD:1600115
RGD:1624291
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component JBrowse link 1 175,839,140 175,869,167 RGD:1624291
RGD:1600115
G Leo1 LEO1 homolog, Paf1/RNA polymerase II complex component JBrowse link 8 82,380,906 82,405,293 RGD:1624291
RGD:1600115
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component JBrowse link 1 85,362,421 85,367,999 RGD:1624291
RGD:1600115
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
RGD:1600115
G Rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) JBrowse link 3 111,478,350 111,537,941 RGD:1624291
endodermal cell fate determination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gata6 GATA binding protein 6 JBrowse link 18 2,415,821 2,447,087 RGD:1624291
RGD:1600115
G Sox17 SRY box 17 JBrowse link 5 14,890,318 14,895,907 RGD:1624291
RGD:1600115
endodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eomes eomesodermin JBrowse link 8 127,144,367 127,152,618 RGD:1624291
G Hnf1b HNF1 homeobox B JBrowse link 10 71,159,863 71,218,902 RGD:1624291
RGD:1600115
G Nanog Nanog homeobox JBrowse link 4 155,531,906 155,539,268 RGD:1624291
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
G Sox2 SRY box 2 JBrowse link 2 121,165,137 121,167,545 RGD:1624291
RGD:1600115
hemangioblast cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor JBrowse link 5 133,864,401 133,878,604 RGD:1624291
RGD:1600115
intermediate mesodermal cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1600115
RGD:1624291
lateral mesodermal cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxf1 forkhead box F1 JBrowse link 19 53,012,306 53,016,100 RGD:1624291
RGD:1600115
mesoderm formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1600115
RGD:1624291
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
RGD:1600115
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
RGD:1600115
G Bmpr2 bone morphogenetic protein receptor type 2 JBrowse link 9 66,568,074 66,683,019 RGD:1624291
RGD:1600115
G Chrd chordin JBrowse link 11 83,858,503 83,867,543 RGD:1624291
RGD:1600115
G Crb2 crumbs cell polarity complex component 2 JBrowse link 3 22,037,812 22,061,247 RGD:1600115
RGD:1624291
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Ecsit ECSIT signalling integrator JBrowse link 8 23,085,598 23,099,064 RGD:1624291
G Eomes eomesodermin JBrowse link 8 127,144,367 127,152,618 RGD:1624291
G Etv2 ets variant 2 JBrowse link 1 89,091,239 89,094,570 RGD:1624291
G Ext2 exostosin glycosyltransferase 2 JBrowse link 3 82,602,784 82,734,557 RGD:1624291
RGD:1600115
G Gpi glucose-6-phosphate isomerase JBrowse link 1 90,063,411 90,091,287 RGD:1624291
RGD:1600115
G Hand1 heart and neural crest derivatives expressed 1 JBrowse link 10 43,250,729 43,253,296 RGD:1624291
RGD:1600115
G Inhba inhibin subunit beta A JBrowse link 17 51,894,869 51,919,998 RGD:1624291
G Macf1 microtubule-actin crosslinking factor 1 JBrowse link 5 141,039,455 141,363,524 RGD:1624291
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:13792537
G Mesp2 mesoderm posterior bHLH transcription factor 2 JBrowse link 1 141,550,633 141,553,239 RGD:13792537
G Msgn1 mesogenin 1 JBrowse link 6 36,876,165 36,876,805 RGD:13792537
G Nf2 neurofibromin 2 JBrowse link 14 84,996,905 85,088,547 RGD:1624291
RGD:1600115
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:1624291
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 JBrowse link 5 63,781,801 63,822,890 RGD:1624291
RGD:1600115
G Pofut2 protein O-fucosyltransferase 2 JBrowse link 20 12,117,811 12,128,747 RGD:1624291
RGD:1600115
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:1624291
RGD:1600115
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha JBrowse link 10 97,940,705 97,959,199 RGD:1624291
RGD:1600115
G Scx scleraxis bHLH transcription factor JBrowse link 7 117,519,075 117,521,093 RGD:1624291
RGD:1600115
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:1624291
RGD:1600115
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1624291
RGD:1600115
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:1624291
RGD:1600115
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:1624291
RGD:1600115
G Tbx6 T-box 6 JBrowse link 1 198,214,797 198,218,706 RGD:1624291
RGD:1600115
G Tlx2 T-cell leukemia homeobox 2 JBrowse link 4 114,766,401 114,768,243 RGD:1624291
G Twsg1 twisted gastrulation BMP signaling modulator 1 JBrowse link 9 113,699,151 113,732,601 RGD:1624291
RGD:1600115
G Txnrd1 thioredoxin reductase 1 JBrowse link 7 26,946,124 26,984,400 RGD:1624291
RGD:1600115
G Wls Wnt ligand secretion mediator JBrowse link 2 266,315,036 266,431,220 RGD:1624291
RGD:1600115
G Wnt3 Wnt family member 3 JBrowse link 10 91,830,709 91,874,907 RGD:1624291
RGD:1600115
mesoderm migration involved in gastrulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Epb41l5 erythrocyte membrane protein band 4.1 like 5 JBrowse link 13 35,622,472 35,673,449 RGD:1624291
RGD:1600115
G LOC100912649 uncharacterized LOC100912649 RGD:1600115
G Tbxt T-box transcription factor T JBrowse link 1 52,887,067 52,900,691 RGD:1624291
RGD:1600115
mesodermal cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:632663
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
RGD:1600115
G Inhba inhibin subunit beta A JBrowse link 17 51,894,869 51,919,998 RGD:1624291
RGD:1600115
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:1624291
RGD:1600115
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:1624291
RGD:1600115
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,893 79,676,927 RGD:1624291
RGD:1600115
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1600115
RGD:1624291
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:1624291
G Itgb4 integrin subunit beta 4 JBrowse link 10 104,524,000 104,560,180 RGD:1600115
RGD:1624291
G Kdm6a lysine demethylase 6A JBrowse link X 4,805,493 4,945,788 RGD:1624291
RGD:1600115
G Kdm6b lysine demethylase 6B JBrowse link 10 56,000,494 56,009,582 RGD:1624291
mesodermal cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nanog Nanog homeobox JBrowse link 4 155,531,906 155,539,268 RGD:1624291
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
RGD:1600115
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:1624291
RGD:1600115
mesodermal cell fate determination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:1624291
G Hoxa11 homeobox A11 JBrowse link 4 82,296,888 82,301,419 RGD:1624291
G Pax2 paired box 2 JBrowse link 1 264,493,579 264,585,073 RGD:1624291
RGD:1600115
G Six2 SIX homeobox 2 JBrowse link 6 8,952,572 8,955,893 RGD:1624291
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fzd7 frizzled class receptor 7 JBrowse link 9 66,305,731 66,308,550 RGD:1624291
RGD:1600115
negative regulation of endodermal cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col5a1 collagen type V alpha 1 chain JBrowse link 3 6,430,180 6,581,010 RGD:1600115
RGD:1624291
G Col5a2 collagen type V alpha 2 chain JBrowse link 9 52,091,088 52,238,735 RGD:1624291
RGD:1600115
negative regulation of endodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
RGD:1600115
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
RGD:1600115
G Sox17 SRY box 17 JBrowse link 5 14,890,318 14,895,907 RGD:1624291
RGD:1600115
paraxial mesoderm formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Exoc4 exocyst complex component 4 JBrowse link 4 60,549,128 61,358,305 RGD:1624291
RGD:1600115
G Foxc1 forkhead box C1 JBrowse link 17 33,947,501 33,951,484 RGD:1624291
RGD:1600115
G Foxc2 forkhead box C2 JBrowse link 19 53,044,379 53,047,081 RGD:1624291
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:1624291
RGD:1600115
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1624291
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:1624291
RGD:13792537
RGD:1600115
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:1624291
RGD:1600115
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
paraxial mesodermal cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxc2 forkhead box C2 JBrowse link 19 53,044,379 53,047,081 RGD:1624291
RGD:1600115
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:1624291
RGD:1600115
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:1624291
RGD:1600115
regulation of endodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Hnf1b HNF1 homeobox B JBrowse link 10 71,159,863 71,218,902 RGD:1624291
RGD:1600115
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
RGD:1600115
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:1624291
RGD:1600115
regulation of mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sox17 SRY box 17 JBrowse link 5 14,890,318 14,895,907 RGD:1624291
regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sox17 SRY box 17 JBrowse link 5 14,890,318 14,895,907 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17895
    developmental process 6321
      anatomical structure formation involved in morphogenesis 1167
        formation of primary germ layer 120
          cell fate commitment involved in formation of primary germ layer + 31
          ectoderm formation + 6
          endoderm formation + 51
          mesoderm formation + 73
Path 2
Term Annotations click to browse term
  biological_process 17895
    developmental process 6321
      anatomical structure development 5927
        multicellular organism development 5423
          embryo development 1211
            embryonic morphogenesis 659
              gastrulation 194
                formation of primary germ layer 120
                  cell fate commitment involved in formation of primary germ layer + 31
                  ectoderm formation + 6
                  endoderm formation + 51
                  mesoderm formation + 73
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.