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ONTOLOGY REPORT - ANNOTATIONS


Term:cell fate specification
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Accession:GO:0001708 term browser browse the term
Definition:The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.


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cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:13792537
G Apc2 APC regulator of WNT signaling pathway 2 JBrowse link 7 12,258,468 12,280,459 RGD:13792537
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:1624291
RGD:1600115
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Dhh desert hedgehog signaling molecule JBrowse link 7 140,575,288 140,580,783 RGD:13792537
G Fkbp8 FKBP prolyl isomerase 8 JBrowse link 16 20,645,956 20,652,890 RGD:1624291
RGD:1600115
G Foxa2 forkhead box A2 JBrowse link 3 142,383,084 142,387,493 RGD:1624291
RGD:1600115
G Ihh Indian hedgehog signaling molecule JBrowse link 9 82,208,223 82,214,440 RGD:1624291
RGD:13792537
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1624291
RGD:1600115
G Mga MAX dimerization protein MGA JBrowse link 3 111,669,645 111,760,822 RGD:13792537
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
RGD:1600115
G Otx2 orthodenticle homeobox 2 JBrowse link 15 25,500,037 25,511,619 RGD:1624291
G Pou1f1 POU class 1 homeobox 1 JBrowse link 11 2,645,659 2,662,581 RGD:1624291
RGD:1600115
G Prdm14 PR/SET domain 14 JBrowse link 5 5,710,076 5,730,560 RGD:1624291
RGD:1600115
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1624291
RGD:1600115
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1600115
RGD:13792537
RGD:1624291
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:1624291
RGD:1600115
G Sox2 SRY-box transcription factor 2 JBrowse link 2 121,165,137 121,167,545 RGD:1624291
G Sox9 SRY-box transcription factor 9 JBrowse link 10 101,288,528 101,294,030 RGD:1624291
RGD:1600115
G Tbr1 T-box brain transcription factor 1 JBrowse link 3 47,677,720 47,685,902 RGD:13792537
G Tbx1 T-box transcription factor 1 JBrowse link 11 86,552,022 86,561,647 RGD:1600115
RGD:13792537
RGD:1624291
G Tbx10 T-box transcription factor 10 JBrowse link 1 219,237,204 219,246,480 RGD:13792537
G Tbx15 T-box transcription factor 15 JBrowse link 2 201,289,042 201,390,752 RGD:13792537
G Tbx18 T-box transcription factor 18 JBrowse link 8 95,359,354 95,387,363 RGD:13792537
G Tbx19 T-box transcription factor 19 JBrowse link 13 83,403,263 83,426,305 RGD:13792537
G Tbx2 T-box transcription factor 2 JBrowse link 10 73,278,932 73,290,764 RGD:13792537
G Tbx20 T-box transcription factor 20 JBrowse link 8 25,849,394 25,904,570 RGD:13792537
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:13792537
G Tbx22 T-box transcription factor 22 JBrowse link X 78,731,738 78,782,542 RGD:13792537
G Tbx3 T-box transcription factor 3 JBrowse link 12 42,479,518 42,494,588 RGD:13792537
G Tbx4 T-box transcription factor 4 JBrowse link 10 73,331,864 73,362,784 RGD:13792537
G Tbx5 T-box transcription factor 5 JBrowse link 12 42,059,688 42,148,226 RGD:13792537
G Tbx6 T-box transcription factor 6 JBrowse link 1 198,214,797 198,218,706 RGD:1624291
RGD:13792537
G Tbxt T-box transcription factor T JBrowse link 1 52,887,067 52,900,691 RGD:13792537
G Tead4 TEA domain transcription factor 4 JBrowse link 4 161,542,566 161,619,848 RGD:1624291
G Tlx3 T-cell leukemia, homeobox 3 JBrowse link 10 18,128,869 18,131,745 RGD:1624291
activation of prostate induction by androgen receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:1624291
RGD:1600115
auditory receptor cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atoh1 atonal bHLH transcription factor 1 JBrowse link 4 95,498,003 95,500,098 RGD:1624291
RGD:1600115
axial mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:1624291
RGD:1600115
blood vessel endothelial cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 14 59,657,738 59,865,427 RGD:1624291
BMP signaling pathway involved in mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Etv2 ETS variant transcription factor 2 JBrowse link 1 89,091,239 89,094,570 RGD:1624291
RGD:1600115
cardiac cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tenm4 teneurin transmembrane protein 4 JBrowse link 1 161,183,858 161,885,094 RGD:1624291
RGD:1600115
endodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eomes eomesodermin JBrowse link 8 127,144,367 127,152,618 RGD:1624291
RGD:1600115
G Hnf1b HNF1 homeobox B JBrowse link 10 71,159,863 71,218,902 RGD:1624291
RGD:1600115
G Nanog Nanog homeobox JBrowse link 4 155,531,906 155,539,268 RGD:1624291
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
G Sox2 SRY-box transcription factor 2 JBrowse link 2 121,165,137 121,167,545 RGD:1624291
RGD:1600115
endothelial cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hoxa13 homeo box A13 RGD:1624291
endothelial tip cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:1600115
RGD:1624291
epidermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:1624291
RGD:1600115
G Ptch2 patched 2 JBrowse link 5 135,962,252 135,983,816 RGD:1624291
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 14 59,657,738 59,865,427 RGD:1624291
mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:1624291
RGD:1600115
G Hoxa11 homeobox A11 JBrowse link 4 82,296,888 82,301,419 RGD:1624291
G Pax2 paired box 2 JBrowse link 1 264,493,579 264,585,073 RGD:1624291
RGD:1600115
G Six2 SIX homeobox 2 JBrowse link 6 8,952,572 8,955,893 RGD:1624291
RGD:1600115
muscle cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myl2 myosin light chain 2 JBrowse link 12 39,951,863 39,959,065 RGD:1624291
RGD:1600115
negative regulation of cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link 14 3,058,035 3,073,332 RGD:1624291
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fzd7 frizzled class receptor 7 JBrowse link 9 66,305,731 66,308,550 RGD:1624291
RGD:1600115
negative regulation of endodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
RGD:1600115
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:1624291
RGD:1600115
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
RGD:1600115
G Sox17 SRY-box transcription factor 17 JBrowse link 5 14,890,318 14,895,907 RGD:1624291
neural crest cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gsc goosecoid homeobox JBrowse link 6 128,147,181 128,149,220 RGD:1624291
RGD:1600115
neuron fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ascl1 achaete-scute family bHLH transcription factor 1 JBrowse link 7 28,038,662 28,040,504 RGD:1600115
RGD:1624291
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:1600115
RGD:1624291
G Dmrta2 DMRT-like family A2 JBrowse link 5 129,754,295 129,760,045 RGD:1624291
G Ehmt2 euchromatic histone lysine methyltransferase 2 JBrowse link 20 4,576,033 4,592,980 RGD:1624291
RGD:1600115
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:1624291
RGD:1600115
G Fev FEV transcription factor, ETS family member JBrowse link 9 82,142,981 82,146,855 RGD:1624291
G Foxa1 forkhead box A1 JBrowse link 6 78,516,579 78,549,669 RGD:1624291
RGD:1600115
G Foxa2 forkhead box A2 JBrowse link 3 142,383,084 142,387,493 RGD:1624291
G Gsx2 GS homeobox 2 JBrowse link 14 35,650,985 35,652,709 RGD:1624291
RGD:1600115
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
RGD:13792537
G Isl2 ISL LIM homeobox 2 JBrowse link 8 60,117,565 60,122,716 RGD:13792537
G Myt1l myelin transcription factor 1-like JBrowse link 6 48,452,385 48,843,443 RGD:1600115
RGD:1624291
G Nkx2-2 NK2 homeobox 2 JBrowse link 3 141,408,460 141,419,083 RGD:1624291
RGD:1600115
G Ntrk3 neurotrophic receptor tyrosine kinase 3 JBrowse link 1 139,890,537 140,262,503 RGD:2325628
G Pou3f2 POU class 3 homeobox 2 JBrowse link 5 36,677,452 36,683,356 RGD:1600115
RGD:1624291
G Pou4f1 POU class 4 homeobox 1 JBrowse link 15 88,618,255 88,622,712 RGD:1624291
RGD:1600115
G Six1 SIX homeobox 1 JBrowse link 6 95,929,060 95,934,296 RGD:1624291
RGD:1600115
G Tlx3 T-cell leukemia, homeobox 3 JBrowse link 10 18,128,869 18,131,745 RGD:1624291
RGD:1600115
oligodendrocyte cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:1624291
RGD:1600115
G Sox6 SRY-box transcription factor 6 JBrowse link 1 185,631,702 186,186,192 RGD:1624291
RGD:1600115
positive regulation of cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:1624291
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link 14 3,058,035 3,073,332 RGD:1624291
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:729590
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
RGD:1600115
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:1624291
RGD:1600115
regulation of cardiac cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sox17 SRY-box transcription factor 17 JBrowse link 5 14,890,318 14,895,907 RGD:1624291
RGD:1600115
regulation of cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lmo4 LIM domain only 4 JBrowse link 2 250,218,635 250,235,435 RGD:1624291
RGD:1600115
regulation of endodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
regulation of heart induction by regulation of canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Esrp1 epithelial splicing regulatory protein 1 JBrowse link 5 24,576,988 24,631,758 RGD:1600115
RGD:1624291
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
RGD:1600115
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:1624291
RGD:1600115
regulation of mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sox17 SRY-box transcription factor 17 JBrowse link 5 14,890,318 14,895,907 RGD:1624291
regulation of neural crest cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sox17 SRY-box transcription factor 17 JBrowse link 5 14,890,318 14,895,907 RGD:1624291
RGD:1600115
regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lbx1 ladybird homeobox 1 JBrowse link 1 264,973,315 264,975,132 RGD:1624291
RGD:1600115
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nkx6-1 NK6 homeobox 1 JBrowse link 14 9,555,264 9,562,197 RGD:1624291
RGD:1600115
G Nkx6-2 NK6 homeobox 2 JBrowse link 1 211,922,389 211,923,929 RGD:1624291
RGD:1600115
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:1624291
RGD:1600115
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Evx1 even-skipped homeobox 1 JBrowse link 4 82,370,829 82,374,313 RGD:1624291
G Nkx6-1 NK6 homeobox 1 JBrowse link 14 9,555,264 9,562,197 RGD:1624291
RGD:1600115
G Nkx6-2 NK6 homeobox 2 JBrowse link 1 211,922,389 211,923,929 RGD:1624291
RGD:1600115
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:1624291
RGD:1600115
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:1624291
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
RGD:1600115
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:1624291
RGD:1600115
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:1624291
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
RGD:1600115
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:1624291
RGD:1600115
spinal cord motor neuron cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hoxc10 homeo box C10 JBrowse link 7 144,577,578 144,582,802 RGD:1624291
RGD:1600115
G Hoxd10 homeo box D10 JBrowse link 3 61,614,133 61,617,342 RGD:1624291
RGD:1600115
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:1624291
RGD:1600115
G Isl2 ISL LIM homeobox 2 JBrowse link 8 60,117,565 60,122,716 RGD:1624291
RGD:1600115
G Lhx3 LIM homeobox 3 JBrowse link 3 3,653,861 3,662,509 RGD:1624291
RGD:1600115
G Mnx1 motor neuron and pancreas homeobox 1 JBrowse link 4 2,376,350 2,381,308 RGD:1624291
RGD:13792537
G Olig3 oligodendrocyte transcription factor 3 JBrowse link 1 14,797,766 14,799,835 RGD:1624291
RGD:1600115
spinal cord oligodendrocyte cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ascl1 achaete-scute family bHLH transcription factor 1 JBrowse link 7 28,038,662 28,040,504 RGD:1624291
RGD:1600115
G Nkx2-2 NK2 homeobox 2 JBrowse link 3 141,408,460 141,419,083 RGD:1624291
RGD:1600115
G Olig2 oligodendrocyte transcription factor 2 JBrowse link 11 31,389,514 31,392,890 RGD:1624291
RGD:1600115
stem cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sox17 SRY-box transcription factor 17 JBrowse link 5 14,890,318 14,895,907 RGD:1624291
RGD:1600115
G Sox18 SRY-box transcription factor 18 JBrowse link 3 177,177,237 177,179,039 RGD:1624291
RGD:1600115
ventral spinal cord interneuron specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dbx1 developing brain homeobox 1 JBrowse link 1 104,969,218 104,973,648 RGD:1624291
RGD:1600115
G Dmrt3 doublesex and mab-3 related transcription factor 3 JBrowse link 1 243,589,607 243,602,926 RGD:1624291
RGD:1600115
G Lhx3 LIM homeobox 3 JBrowse link 3 3,653,861 3,662,509 RGD:1624291
RGD:1600115
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:8553789
G Sox1 SRY-box transcription factor 1 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    cellular process 17125
      cellular developmental process 4400
        cell fate specification 102
          abaxial cell fate specification 0
          anther wall tapetum cell fate specification 0
          bundle sheath cell fate specification 0
          cardiac cell fate specification + 3
          cell fate specification involved in pattern specification + 12
          compound eye cone cell fate specification + 0
          ectodermal cell fate specification + 1
          endodermal cell fate specification + 8
          endothelial cell fate specification + 3
          eosinophil fate specification 0
          epidermal cell fate specification + 3
          epithelial cell type specification, open tracheal system + 0
          glial cell fate specification + 5
          mesodermal cell fate specification + 13
          muscle cell fate specification + 1
          myoblast fate specification + 0
          negative regulation of cell fate specification + 7
          neuron fate specification + 37
          plant epidermal cell fate specification + 0
          positive regulation of cell fate specification + 4
          regulation of cell fate specification + 15
          skeletal muscle satellite cell fate specification 0
          stem cell fate specification + 4
          vulval cell fate specification 0
Path 2
Term Annotations click to browse term
  biological_process 19245
    cellular process 17125
      cellular developmental process 4400
        cell differentiation 4180
          cell fate commitment 282
            cell fate specification 102
              abaxial cell fate specification 0
              anther wall tapetum cell fate specification 0
              bundle sheath cell fate specification 0
              cardiac cell fate specification + 3
              cell fate specification involved in pattern specification + 12
              compound eye cone cell fate specification + 0
              ectodermal cell fate specification + 1
              endodermal cell fate specification + 8
              endothelial cell fate specification + 3
              eosinophil fate specification 0
              epidermal cell fate specification + 3
              epithelial cell type specification, open tracheal system + 0
              glial cell fate specification + 5
              mesodermal cell fate specification + 13
              muscle cell fate specification + 1
              myoblast fate specification + 0
              negative regulation of cell fate specification + 7
              neuron fate specification + 37
              plant epidermal cell fate specification + 0
              positive regulation of cell fate specification + 4
              regulation of cell fate specification + 15
              skeletal muscle satellite cell fate specification 0
              stem cell fate specification + 4
              vulval cell fate specification 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.