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ONTOLOGY REPORT - ANNOTATIONS


Term:ruffle
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Accession:GO:0001726 term browser browse the term
Definition:Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
Synonyms:related_synonym: membrane ruffle


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ruffle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1598670
G Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 JBrowse link 11 73,078,966 73,193,496 RGD:1624291
RGD:1600115
G Actn1 actinin, alpha 1 JBrowse link 6 103,376,557 103,470,497 RGD:1600115
RGD:1624291
G Actr3 actin related protein 3 JBrowse link 13 41,695,520 41,738,622 RGD:2306208
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:1624291
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 JBrowse link 9 65,961,361 66,034,396 RGD:1624291
G Amot angiomotin JBrowse link X 116,751,231 116,810,238 RGD:1624291
G Anxa2 annexin A2 JBrowse link 8 75,687,134 75,723,589 RGD:7242275
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 JBrowse link 16 2,560,103 2,602,035 RGD:1624291
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 JBrowse link 7 26,256,179 26,306,128 RGD:1624291
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 JBrowse link 18 31,112,083 31,138,142 RGD:1624291
RGD:13792537
G Arf6 ADP-ribosylation factor 6 JBrowse link 6 91,697,109 91,698,257 RGD:727254
RGD:13792537
RGD:1624291
G Arfip2 ADP-ribosylation factor interacting protein 2 JBrowse link 1 170,464,995 170,471,138 RGD:1624291
G Arhgap1 Rho GTPase activating protein 1 JBrowse link 3 80,555,196 80,576,881 RGD:1624291
G Arhgap18 Rho GTPase activating protein 18 JBrowse link 1 19,227,115 19,463,139 RGD:1624291
G Arhgef7 Rho guanine nucleotide exchange factor 7 JBrowse link 16 83,006,732 83,117,065 RGD:1600115
G Asap3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 JBrowse link 5 154,551,901 154,596,125 RGD:1624291
RGD:13792537
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 JBrowse link 16 22,326,537 22,350,143 RGD:1624291
G Baiap2 BAR/IMD domain containing adaptor protein 2 JBrowse link 10 109,107,326 109,187,458 RGD:1600115
G Bcar1 BCAR1 scaffold protein, Cas family member JBrowse link 19 43,932,543 43,967,452 RGD:1600115
RGD:1624291
G Capg capping actin protein, gelsolin like JBrowse link 4 100,395,693 100,419,447 RGD:1600115
G Carmil2 capping protein regulator and myosin 1 linker 2 JBrowse link 19 37,652,383 37,665,333 RGD:1624291
G Cd2ap CD2-associated protein JBrowse link 9 20,794,680 20,858,438 RGD:1624291
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:1624291
G Cit citron rho-interacting serine/threonine kinase JBrowse link 12 46,334,669 46,494,152 RGD:1624291
G Clip1 CAP-GLY domain containing linker protein 1 JBrowse link 12 38,345,203 38,452,650 RGD:1600115
G Cobl cordon-bleu WH2 repeat protein JBrowse link 14 92,341,949 92,497,169 RGD:1624291
RGD:13792537
RGD:1600115
G Cspg4 chondroitin sulfate proteoglycan 4 JBrowse link 8 61,532,465 61,567,510 RGD:1600115
RGD:1624291
G Cttn cortactin JBrowse link 1
1
217,602,698
215,255,385
217,638,196
215,290,882
RGD:1624291
G Cyth2 cytohesin 2 JBrowse link 1 101,796,349 101,803,407 RGD:625544
G Cyth3 cytohesin 3 JBrowse link 12 12,877,559 12,907,771 RGD:1624291
RGD:1600115
G Dbnl drebrin-like JBrowse link 14 86,029,335 86,044,364 RGD:1624291
RGD:1600115
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1624291
G Fgd1 FYVE, RhoGEF and PH domain containing 1 JBrowse link X 20,100,942 20,143,871 RGD:1624291
G Fgd2 FYVE, RhoGEF and PH domain containing 2 JBrowse link 20 6,973,356 6,990,026 RGD:1624291
G Frmd4b FERM domain containing 4B JBrowse link 4 129,658,137 129,984,735 RGD:1624291
G Fscn1 fascin actin-bundling protein 1 JBrowse link 12 13,655,459 13,668,595 RGD:2317778
RGD:13792537
RGD:1624291
G Fscn3 fascin actin-bundling protein 3 JBrowse link 4 55,719,976 55,729,442 RGD:13792537
G Gas7 growth arrest specific 7 JBrowse link 10 54,010,723 54,240,805 RGD:1624291
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:5509808
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:1599859
G Inpp5e inositol polyphosphate-5-phosphatase E JBrowse link 3 3,843,307 3,856,154 RGD:1299274
G Inpp5j inositol polyphosphate-5-phosphatase J JBrowse link 14 83,730,861 83,742,016 RGD:633686
RGD:13792537
RGD:1624291
G Inpp5k inositol polyphosphate-5-phosphatase K JBrowse link 10 63,775,639 63,796,879 RGD:1624291
RGD:13792537
G Iqgap1 IQ motif containing GTPase activating protein 1 JBrowse link 1 142,525,041 142,615,673 RGD:1624291
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:1624291
G Kif18a kinesin family member 18A JBrowse link 3 100,366,168 100,426,867 RGD:1624291
G Klhl2 kelch-like family member 2 JBrowse link 16 26,755,246 26,852,134 RGD:1600115
G Klhl41 kelch-like family member 41 JBrowse link 3 55,910,177 55,923,303 RGD:1600115
G Knstrn kinetochore-localized astrin/SPAG5 binding protein JBrowse link 3 110,618,256 110,638,024 RGD:1624291
G Lcp1 lymphocyte cytosolic protein 1 JBrowse link 15 57,170,566 57,277,811 RGD:1624291
G Lima1 LIM domain and actin binding 1 JBrowse link 7 141,428,113 141,528,447 RGD:1600115
RGD:1624291
G Mefv MEFV innate immuity regulator, pyrin JBrowse link 10 12,045,813 12,056,229 RGD:1600115
G Mkln1 muskelin 1 JBrowse link 4 58,693,384 58,817,924 RGD:1600115
RGD:1624291
G Mtm1 myotubularin 1 JBrowse link 6 18,821,821 18,840,449 RGD:1600115
RGD:1624291
G Mtmr14 myotubularin related protein 14 JBrowse link 4 145,195,046 145,238,097 RGD:1624291
G Mtss2 MTSS I-BAR domain containing 2 JBrowse link 19 40,904,779 40,925,660 RGD:1624291
G Myadm myeloid-associated differentiation marker JBrowse link 1 64,438,465 64,448,332 RGD:1624291
RGD:1600115
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:1624291
G Myh9l1 myosin heavy chain 9-like 1 JBrowse link 7 118,991,251 119,071,722 RGD:1600115
G Myo10 myosin X JBrowse link 2 77,868,398 78,072,443 RGD:1600115
G Myo5a myosin VA JBrowse link 8 82,038,966 82,156,507 RGD:1624291
RGD:1600115
G Myo6 myosin VI JBrowse link 8 87,583,649 87,731,271 RGD:1624291
RGD:13792537
G Myo9b myosin IXb JBrowse link 16 19,669,373 19,754,065 RGD:1581711
RGD:1624291
G Nckap1 NCK-associated protein 1 JBrowse link 3 67,725,180 67,804,680 RGD:1624291
G Nf2 neurofibromin 2 JBrowse link 14 84,996,905 85,088,547 RGD:1624291
RGD:1600115
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 JBrowse link 10 81,648,216 81,653,717 RGD:1624291
RGD:1600115
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1600115
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:11533928
RGD:1600115
RGD:1624291
G Palld palladin, cytoskeletal associated protein JBrowse link 16 31,865,712 31,948,168 RGD:2325783
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:1624291
G Pdlim7 PDZ and LIM domain 7 JBrowse link 17 9,653,510 9,668,715 RGD:1624291
G Pdpn podoplanin JBrowse link 5 161,947,137 161,981,441 RGD:1624291
RGD:1600115
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:11541088
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:1600115
RGD:1624291
G Podxl podocalyxin-like JBrowse link 4 58,829,049 58,893,353 RGD:1624291
RGD:1600115
G Ptk6 protein tyrosine kinase 6 JBrowse link 3 176,698,305 176,706,896 RGD:1624291
G Rab34 RAB34, member RAS oncogene family JBrowse link 10 65,448,111 65,452,178 RGD:1624291
G Rab5a RAB5A, member RAS oncogene family JBrowse link 9 5,910 6,065 RGD:1624291
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:1624291
RGD:1600115
G Rdx radixin JBrowse link 8 56,570,728 56,612,851 RGD:1624291
G Rinl Ras and Rab interactor-like JBrowse link 1 86,971,997 86,983,306 RGD:1624291
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:1600115
RGD:1624291
G S100a11 S100 calcium binding protein A11 JBrowse link 2 193,863,185 193,868,646 RGD:1624291
G S100a6 S100 calcium binding protein A6 JBrowse link 2 190,007,013 190,008,512 RGD:1624291
G S100b S100 calcium binding protein B JBrowse link 20 13,130,633 13,142,856 RGD:1624291
G Scimp SLP adaptor and CSK interacting membrane protein JBrowse link 10 57,415,429 57,436,412 RGD:1624291
G Sh2b2 SH2B adaptor protein 2 JBrowse link 12 23,471,477 23,501,043 RGD:1624291
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link 10 103,713,045 103,730,145 RGD:1600115
G Snx5 sorting nexin 5 JBrowse link 3 138,378,032 138,397,944 RGD:1600115
G Tesc tescalcin JBrowse link 12 44,141,258 44,174,701 RGD:1624291
G Tln1 talin 1 JBrowse link 5 59,033,635 59,063,592 RGD:1600115
G Tln2 talin 2 JBrowse link 8 73,009,980 73,441,536 RGD:1600115
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1600115
G Tnfrsf12a TNF receptor superfamily member 12A JBrowse link 10 12,995,904 12,997,930 RGD:1624291
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 JBrowse link 3 119,258,189 119,347,084 RGD:1624291
RGD:1600115
G Vil1 villin 1 JBrowse link 9 81,689,802 81,717,623 RGD:1624291
G Wasf2 WASP family member 2 JBrowse link 5 151,319,382 151,385,051 RGD:1624291
G Wipf1 WAS/WASL interacting protein family, member 1 JBrowse link 3 60,150,001 60,207,125 RGD:1600115
ruffle membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca7 ATP binding cassette subfamily A member 7 JBrowse link 7 12,742,433 12,762,423 RGD:1624291
RGD:1600115
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:1624291
RGD:1600115
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:1624291
RGD:13792537
RGD:1600115
G Aif1l allograft inflammatory factor 1-like JBrowse link 3 9,237,944 9,262,628 RGD:13792537
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:1600115
RGD:1624291
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:1624291
RGD:1600115
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 JBrowse link 7 26,256,179 26,306,128 RGD:1624291
G Arf4 ADP-ribosylation factor 4 JBrowse link 16 2,338,333 2,354,909 RGD:1624291
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 JBrowse link 2 187,964,100 188,022,847 RGD:1624291
RGD:13792537
RGD:1600115
G Arpc2 actin related protein 2/3 complex, subunit 2 JBrowse link 9 81,518,163 81,548,871 RGD:2306207
G Bmx BMX non-receptor tyrosine kinase JBrowse link X 31,976,231 32,046,326 RGD:1624291
G C2cd5 C2 calcium-dependent domain containing 5 JBrowse link 4 177,245,868 177,331,910 RGD:1624291
G Cdc37 cell division cycle 37, HSP90 cochaperone JBrowse link 8 22,160,922 22,173,797 RGD:5131523
G Cdkl5 cyclin-dependent kinase-like 5 JBrowse link X 35,536,396 35,773,204 RGD:8554575
G Cfl1 cofilin 1 JBrowse link 1 220,869,805 220,873,337 RGD:1600115
G Cib1 calcium and integrin binding 1 JBrowse link 1 142,014,962 142,020,461 RGD:1600115
G Clasp2 cytoplasmic linker associated protein 2 JBrowse link 8 122,003,719 122,185,495 RGD:1624291
RGD:28912745
RGD:1600115
G Ddx58 DEXD/H-box helicase 58 JBrowse link 5 56,486,584 56,536,898 RGD:1624291
G Diaph1 diaphanous-related formin 1 JBrowse link 18 30,972,907 31,071,371 RGD:1624291
G Dlc1 DLC1 Rho GTPase activating protein JBrowse link 16 58,776,489 59,247,752 RGD:1600115
RGD:1624291
G Dnm2 dynamin 2 JBrowse link 8 22,458,869 22,540,649 RGD:9685132
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 JBrowse link 8 85,838,594 85,841,816 RGD:1624291
G Epb41l5 erythrocyte membrane protein band 4.1 like 5 JBrowse link 13 35,622,472 35,673,449 RGD:1624291
G Eps8 epidermal growth factor receptor pathway substrate 8 JBrowse link 4 171,475,155 171,645,620 RGD:1624291
RGD:13792537
RGD:1600115
G Eps8l1 EPS8-like 1 JBrowse link 1 72,926,106 72,942,433 RGD:1624291
RGD:13792537
G Eps8l2 EPS8-like 2 JBrowse link 1 214,327,992 214,353,466 RGD:1624291
RGD:13792537
G Eps8l3 EPS8 like 3 JBrowse link 2 210,668,249 210,681,930 RGD:13792537
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1600115
G Fam107a family with sequence similarity 107, member A JBrowse link 15 18,399,145 18,415,959 RGD:1600115
RGD:1624291
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link 5 151,172,189 151,199,746 RGD:1624291
RGD:1600115
G Hip1r huntingtin interacting protein 1 related JBrowse link 12 38,024,517 38,053,184 RGD:1624291
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:1624291
G Inpp5k inositol polyphosphate-5-phosphatase K JBrowse link 10 63,775,639 63,796,879 RGD:1624291
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1624291
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:1624291
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1624291
RGD:1600115
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:1624291
G Jcad junctional cadherin 5 associated JBrowse link 17 55,667,754 55,709,738 RGD:1624291
RGD:13792537
G Kank1 KN motif and ankyrin repeat domains 1 JBrowse link 1 243,201,073 243,398,531 RGD:1624291
G Macf1 microtubule-actin crosslinking factor 1 JBrowse link 5 141,039,455 141,363,524 RGD:1600115
RGD:1624291
G Map2 microtubule-associated protein 2 JBrowse link 9 73,204,753 73,462,965 RGD:12793013
G Mtmr6 myotubularin related protein 6 JBrowse link 15 40,558,917 40,597,311 RGD:1600115
G Mtss2 MTSS I-BAR domain containing 2 JBrowse link 19 40,904,779 40,925,660 RGD:1624291
G Myo1c myosin 1C JBrowse link 10 63,803,311 63,819,614 RGD:11073622
G Myo6 myosin VI JBrowse link 8 87,583,649 87,731,271 RGD:2314969
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 JBrowse link 10 81,657,152 81,666,542 RGD:1624291
G Pacsin1 protein kinase C and casein kinase substrate in neurons 1 JBrowse link 20 7,241,248 7,286,702 RGD:1624291
RGD:1600115
G Pacsin2 protein kinase C and casein kinase substrate in neurons 2 JBrowse link 7 124,224,210 124,317,407 RGD:1600115
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:1600115
G Pde9a phosphodiesterase 9A JBrowse link 20 10,123,624 10,216,325 RGD:1600115
G Pdpn podoplanin JBrowse link 5 161,947,137 161,981,441 RGD:1624291
RGD:1600115
G Pdxp pyridoxal phosphatase JBrowse link 7 120,140,460 120,145,908 RGD:1600115
RGD:1624291
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha JBrowse link 2 196,227,669 196,270,949 RGD:1624291
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma JBrowse link 7 11,267,207 11,294,291 RGD:1600115
G Pla2g4f phospholipase A2, group IVF JBrowse link 3 112,068,617 112,083,978 RGD:1624291
RGD:13792537
G Plek pleckstrin JBrowse link 14 100,151,518 100,184,192 RGD:1624291
G Plekha1 pleckstrin homology domain containing A1 JBrowse link 1 201,429,716 201,481,411 RGD:1624291
G Plekho1 pleckstrin homology domain containing O1 JBrowse link 2 198,112,104 198,120,202 RGD:1624291
RGD:1600115
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B JBrowse link 10 82,800,704 82,816,735 RGD:1624291
RGD:1600115
G Psd pleckstrin and Sec7 domain containing JBrowse link 1 266,059,331 266,074,774 RGD:1624291
RGD:1600115
G Psd2 pleckstrin and Sec7 domain containing 2 JBrowse link 18 28,781,267 28,832,429 RGD:1624291
G Psd3 pleckstrin and Sec7 domain containing 3 JBrowse link 16 23,212,165 23,789,414 RGD:1624291
RGD:13792537
G Psd4 pleckstrin and Sec7 domain containing 4 JBrowse link 3 1,478,432 1,515,094 RGD:1624291
RGD:13792537
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 JBrowse link 4 49,941,046 50,140,764 RGD:9589125
G Rab34 RAB34, member RAS oncogene family JBrowse link 10 65,448,111 65,452,178 RGD:1624291
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1624291
G Rasgrp2 RAS guanyl releasing protein 2 JBrowse link 1 221,771,238 221,788,765 RGD:1600115
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1624291
G Rps3 ribosomal protein S3 JBrowse link 1 164,435,868 164,441,167 RGD:1624291
G Sh3yl1 SH3 and SYLF domain containing 1 JBrowse link 6 49,851,778 49,895,502 RGD:1624291
RGD:13792537
G Sntg1 syntrophin, gamma 1 JBrowse link 5 10,118,901 10,493,094 RGD:1624291
G Spata13 spermatogenesis associated 13 JBrowse link 15 40,937,652 41,066,645 RGD:1624291
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1624291
G Synj2 synaptojanin 2 JBrowse link 1 46,835,922 46,932,544 RGD:628465
G Synj2_v1 synaptojanin 2, variant 1 RGD:628465
G Synj2_v2 synaptojanin 2, variant 2 RGD:628465
G Synj2_v3 synaptojanin 2, variant 3 RGD:628465
G Them4 thioesterase superfamily member 4 JBrowse link 2 195,554,092 195,576,710 RGD:1600115
G Tiam1 TIAM Rac1 associated GEF 1 JBrowse link 11 29,931,083 30,061,173 RGD:629540
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Tpm1 tropomyosin 1 JBrowse link 8 72,814,737 72,841,496 RGD:1624291
RGD:1600115
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 JBrowse link 12 47,698,915 47,737,902 RGD:8553293
G Twf1 twinfilin actin-binding protein 1 JBrowse link 7 135,838,647 135,850,542 RGD:1624291
G Wwc1 WW and C2 domain containing 1 JBrowse link 10 20,662,996 20,818,500 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20300
    cellular anatomical entity 19956
      cell leading edge 443
        ruffle 175
          ruffle membrane 85
Path 2
Term Annotations click to browse term
  cellular_component 20300
    cellular anatomical entity 19956
      cell projection 2529
        plasma membrane bounded cell projection 2462
          ruffle 175
            ruffle membrane 85
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.