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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse


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immunological synapse formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Cd6 Cd6 molecule JBrowse link 1 226,848,399 226,887,259 RGD:1624291
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Coro1a coronin 1A JBrowse link 1 198,123,883 198,128,890 RGD:1624291
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:1624291
RGD:1600115
G Dock2 dedicator of cytokinesis 2 JBrowse link 10 19,181,512 19,603,171 RGD:1624291
G Dock8 dedicator of cytokinesis 8 JBrowse link 1 242,934,685 243,153,472 RGD:1624291
G Ephb1 Eph receptor B1 JBrowse link 8 110,376,954 110,813,193 RGD:10047256
G Git1 GIT ArfGAP 1 JBrowse link 10 62,656,000 62,664,467 RGD:10047256
G Msn moesin JBrowse link X 65,226,834 65,294,192 RGD:1600115
RGD:1624291
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:10047256
G Prf1 perforin 1 JBrowse link 20 30,915,294 30,920,804 RGD:1624291
RGD:1600115
G Spag6l sperm associated antigen 6-like JBrowse link 11 88,424,493 88,517,910 RGD:1600115
negative regulation of immunological synapse formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:1624291
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:1624291
positive regulation of immunological synapse formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    cellular process 18361
      cell recognition 233
        cell-cell recognition 65
          immunological synapse formation 16
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 1
            regulation of immunological synapse formation + 3
Path 2
Term Annotations click to browse term
  biological_process 19576
    cellular process 18361
      cell activation 1131
        leukocyte activation 1008
          lymphocyte activation 828
            immunological synapse formation 16
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 1
              regulation of immunological synapse formation + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.