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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse
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Accession:GO:0001772 term browser browse the term
Definition:An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: supramolecular activation cluster
 narrow_synonym: c-SMAC
 xref: Wikipedia:Immunological_synapse


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immunological synapse term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alcam activated leukocyte cell adhesion molecule JBrowse link 11 50,780,735 50,985,083 RGD:1624291
RGD:1600115
G Arhgdia Rho GDP dissociation inhibitor alpha JBrowse link 10 109,754,012 109,757,506 RGD:1624291
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 JBrowse link 7 41,114,606 41,223,138 RGD:1600115
RGD:1624291
G Bcl10 BCL10, immune signaling adaptor JBrowse link 2 251,805,392 251,814,957 RGD:1624291
G Card11 caspase recruitment domain family, member 11 JBrowse link 12 15,700,600 15,844,512 RGD:1624291
G Carmil2 capping protein regulator and myosin 1 linker 2 JBrowse link 19 37,652,383 37,665,333 RGD:1624291
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:1624291
RGD:1600115
G Cd37 CD37 molecule JBrowse link 1 101,230,470 101,236,061 RGD:1600115
RGD:1624291
G Cd3e CD3e molecule JBrowse link 8 49,297,604 49,309,370 RGD:1624291
G Cd53 Cd53 molecule JBrowse link 2 209,489,279 209,537,098 RGD:1624291
G Cd6 Cd6 molecule JBrowse link 1 226,848,399 226,887,259 RGD:1624291
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Coro1a coronin 1A JBrowse link 1 198,123,883 198,128,890 RGD:1624291
G Crtam cytotoxic and regulatory T cell molecule JBrowse link 8 45,152,584 45,216,082 RGD:1624291
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:1624291
RGD:1600115
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:1624291
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1624291
G Fyb2 FYN binding protein 2 JBrowse link 5 124,442,386 124,561,766 RGD:1624291
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:1624291
G Itgal integrin subunit alpha L JBrowse link 1 198,744,053 198,781,745 RGD:1624291
G Lat linker for activation of T cells JBrowse link 1 197,765,644 197,770,669 RGD:1624291
RGD:13792537
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:1624291
RGD:1600115
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:1624291
RGD:13792537
RGD:1600115
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:1624291
G Nptn neuroplastin JBrowse link 8 63,379,062 63,445,694 RGD:1600115
RGD:1624291
G Pdcd6ip programmed cell death 6 interacting protein JBrowse link 8 121,916,233 121,973,145 RGD:1624291
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha JBrowse link 10 97,940,705 97,959,199 RGD:1624291
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:1600115
RGD:1624291
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
G Rhoh ras homolog family member H JBrowse link 14 43,961,756 43,992,587 RGD:1624291
G Scimp SLP adaptor and CSK interacting membrane protein JBrowse link 10 57,415,429 57,436,412 RGD:1624291
RGD:13792537
G Scrib scribble planar cell polarity protein JBrowse link 7 117,105,810 117,128,802 RGD:1600115
RGD:1624291
G Skap1 src kinase associated phosphoprotein 1 JBrowse link 10 84,309,379 84,619,051 RGD:1624291
G Snx27 sorting nexin 27 JBrowse link 2 195,738,613 195,821,608 RGD:1600115
RGD:1624291
G Socs6 suppressor of cytokine signaling 6 JBrowse link 18 85,962,729 85,981,125 RGD:1624291
G Stoml2 stomatin like 2 JBrowse link 5 58,472,561 58,476,158 RGD:1624291
RGD:1600115
G Stx7 syntaxin 7 JBrowse link 1 22,241,655 22,281,850 RGD:1624291
G Vav3 vav guanine nucleotide exchange factor 3 JBrowse link 2 212,247,061 212,585,818 RGD:1600115
RGD:1624291
G Zap70 zeta chain of T cell receptor associated protein kinase 70 JBrowse link 9 43,331,149 43,353,097 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19809
    cellular anatomical entity 19424
      immunological synapse 40
Path 2
Term Annotations click to browse term
  cellular_component 19809
    cellular anatomical entity 19424
      membrane 9916
        plasma membrane 6048
          immunological synapse 40
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.