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ONTOLOGY REPORT - ANNOTATIONS


Term:leukocyte homeostasis
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Accession:GO:0001776 term browser browse the term
Definition:The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Comment:Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
Synonyms:exact_synonym: immune cell homeostasis;   leucocyte homeostasis


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leukocyte homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:1624291
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
G Cxcl6 C-X-C motif chemokine ligand 6 JBrowse link 14 18,860,201 18,920,839 RGD:1624291
G Flt3 fms-related tyrosine kinase 3 JBrowse link 12 9,360,439 9,437,004 RGD:1624291
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:1624291
G Nkx2-3 NK2 homeobox 3 JBrowse link 1 263,361,238 263,371,043 RGD:1624291
RGD:1600115
activation-induced cell death of T cells term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
RGD:1600115
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
RGD:1600115
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:1624291
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:1624291
RGD:1600115
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:1624291
G Siva1 SIVA1, apoptosis-inducing factor JBrowse link 6 137,209,999 137,214,379 RGD:1624291
B cell homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:1624291
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:1624291
RGD:1600115
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
RGD:1624291
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1600115
RGD:1624291
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
RGD:1600115
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
RGD:1600115
G Dock10 dedicator of cytokinesis 10 JBrowse link 9
9
86,424,638
86,312,470
86,571,854
86,423,054
RGD:1624291
G Dock11 dedicator of cytokinesis 11 JBrowse link X 122,507,169 122,690,463 RGD:1624291
RGD:1600115
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
RGD:1600115
G Gapt Grb2-binding adaptor protein, transmembrane JBrowse link 2 41,869,555 41,874,130 RGD:1624291
RGD:13792537
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:1624291
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:1624291
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1624291
RGD:1600115
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:1600115
RGD:1624291
G Nckap1l NCK associated protein 1 like JBrowse link 7 145,068,239 145,113,507 RGD:1624291
RGD:1600115
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:1624291
G Pirb paired Ig-like receptor B JBrowse link 1 64,074,097 64,081,568 RGD:1624291
G Pkn1 protein kinase N1 JBrowse link 19 24,803,524 24,832,305 RGD:1624291
RGD:1600115
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma JBrowse link 6 76,056,585 76,079,755 RGD:1624291
RGD:13792537
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link 3 21,621,976 21,676,789 RGD:1624291
RGD:1600115
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:1624291
RGD:1600115
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:1624291
G Spns2 sphingolipid transporter 2 JBrowse link 10 59,010,428 59,049,482 RGD:1624291
G Tnfrsf13b TNF receptor superfamily member 13B JBrowse link 10 47,399,834 47,422,907 RGD:1624291
RGD:13792537
G Tnfrsf13c TNF receptor superfamily member 13C JBrowse link 7 123,453,799 123,456,289 RGD:1624291
RGD:1600115
G Tnfsf13b TNF superfamily member 13b JBrowse link 16 85,275,690 85,306,419 RGD:1624291
RGD:1600115
B-1 B cell homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
RGD:1600115
G Sh2b2 SH2B adaptor protein 2 JBrowse link 12 23,471,477 23,501,043 RGD:1624291
RGD:1600115
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
RGD:1600115
basophil homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mpl MPL proto-oncogene, thrombopoietin receptor JBrowse link 5 137,268,412 137,282,032 RGD:10449003
dendritic cell homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt3 fms-related tyrosine kinase 3 JBrowse link 12 9,360,439 9,437,004 RGD:1624291
G Gpr183 G protein-coupled receptor 183 JBrowse link 15 108,364,701 108,376,221 RGD:1600115
RGD:1624291
eosinophil homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mpl MPL proto-oncogene, thrombopoietin receptor JBrowse link 5 137,268,412 137,282,032 RGD:10449003
lymphocyte homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:1624291
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
G Foxn1 forkhead box N1 JBrowse link 10 65,621,142 65,634,666 RGD:1624291
G Lat linker for activation of T cells JBrowse link 1 197,765,644 197,770,669 RGD:1624291
RGD:1600115
G Skil SKI-like proto-oncogene JBrowse link 2 115,862,932 115,891,304 RGD:1624291
RGD:1600115
G Slc40a1 solute carrier family 40 member 1 JBrowse link 9 52,819,451 52,830,461 RGD:1624291
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:1624291
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:1624291
G Spns2 sphingolipid transporter 2 JBrowse link 10 59,010,428 59,049,482 RGD:1624291
G Spta1 spectrin, alpha, erythrocytic 1 JBrowse link 13 92,264,231 92,340,091 RGD:1624291
RGD:1600115
G Tnfrsf17 TNF receptor superfamily member 17 JBrowse link 10 4,252,097 4,258,335 RGD:1624291
RGD:1600115
macrophage homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bap1 Brca1 associated protein 1 JBrowse link 16 7,336,685 7,345,511 RGD:1624291
RGD:1600115
monocyte homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mpl MPL proto-oncogene, thrombopoietin receptor JBrowse link 5 137,268,412 137,282,032 RGD:10449003
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1600115
negative regulation of activation-induced cell death of T cells term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
RGD:1600115
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial JBrowse link 1 275,843,823 275,906,880 RGD:1624291
RGD:1600115
G Tnfrsf4 TNF receptor superfamily member 4 JBrowse link 5 173,447,784 173,450,474 RGD:1624291
RGD:13792537
G Tsc22d3 TSC22 domain family, member 3 JBrowse link X 111,884,285 111,944,693 RGD:1624291
negative regulation of mast cell apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link 13 89,601,894 89,606,326 RGD:1624291
RGD:1600115
G Il3 interleukin 3 JBrowse link 10 39,620,535 39,622,973 RGD:1624291
G Kitlg KIT ligand JBrowse link 7 42,269,784 42,351,054 RGD:1624291
RGD:1600115
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1624291
negative regulation of mature B cell apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ada adenosine deaminase JBrowse link 3 160,115,840 160,139,947 RGD:1624291
RGD:1600115
G Bcl10 BCL10, immune signaling adaptor JBrowse link 2 251,805,392 251,814,957 RGD:1624291
RGD:1600115
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:1624291
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
RGD:1600115
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:1624291
negative regulation of neutrophil apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cxcr2 C-X-C motif chemokine receptor 2 JBrowse link 9 81,427,275 81,435,065 RGD:7257693
G Fcgr2b Fc fragment of IgG receptor IIb JBrowse link 13 89,329,298 89,343,916 RGD:5147925
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:8655995
G Itpkb inositol-trisphosphate 3-kinase B JBrowse link 13 98,615,287 98,710,426 RGD:1624291
RGD:1600115
negative regulation of T cell homeostatic proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd24 CD24 molecule JBrowse link 20 48,335,540 48,340,847 RGD:1624291
RGD:1600115
neutrophil apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hcar2 hydroxycarboxylic acid receptor 2 JBrowse link 12 38,160,464 38,161,546 RGD:1624291
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
RGD:1600115
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
RGD:1600115
neutrophil clearance term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:1624291
RGD:13792537
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:1624291
RGD:1600115
G Ccr2 C-C motif chemokine receptor 2 RGD:1624291
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
RGD:1600115
G Mertk MER proto-oncogene, tyrosine kinase JBrowse link 3 121,235,230 121,340,932 RGD:1624291
RGD:1600115
neutrophil homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:1624291
G Jam3 junctional adhesion molecule 3 JBrowse link 8 28,147,110 28,208,466 RGD:1624291
RGD:1600115
G Mecom MDS1 and EVI1 complex locus JBrowse link 2 117,396,084 117,993,604 RGD:1624291
G Mpl MPL proto-oncogene, thrombopoietin receptor JBrowse link 5 137,268,412 137,282,032 RGD:10449003
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 JBrowse link 6 99,282,850 99,350,367 RGD:1624291
G Pde4b phosphodiesterase 4B JBrowse link 5 121,759,236 122,136,814 RGD:1624291
RGD:1600115
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1600115
G Slc37a4 solute carrier family 37 member 4 JBrowse link 8 48,716,914 48,723,024 RGD:1624291
RGD:1600115
positive regulation of activated T cell autonomous cell death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
positive regulation of activation-induced cell death of T cells term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 carcinoembryonic antigen related cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
positive regulation of neutrophil apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:1624291
RGD:13792537
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:2289387
G Fcar Fc fragment of IgA receptor JBrowse link 1 73,230,392 73,263,462 RGD:1624291
G Hcar2 hydroxycarboxylic acid receptor 2 JBrowse link 12 38,160,464 38,161,546 RGD:1624291
RGD:1600115
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:1624291
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:1624291
RGD:1600115
positive regulation of T cell homeostatic proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd24 CD24 molecule JBrowse link 20 48,335,540 48,340,847 RGD:1624291
RGD:1600115
regulation of activation-induced cell death of T cells term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:1624291
RGD:1600115
regulation of mast cell apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:1624291
regulation of neutrophil apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:1624291
RGD:1600115
regulation of T cell homeostatic proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:1624291
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:1624291
RGD:1600115
G Lmo1 LIM domain only 1 JBrowse link 1 173,728,183 173,764,288 RGD:1624291
RGD:1600115
T cell homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:1624291
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1600115
RGD:1624291
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
RGD:1600115
G Cacna1f calcium voltage-gated channel subunit alpha1 F JBrowse link X 15,712,709 15,741,135 RGD:1600115
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
RGD:1600115
G Ccnb2 cyclin B2 JBrowse link 8 76,847,972 76,861,165 RGD:1624291
G Chst3 carbohydrate sulfotransferase 3 JBrowse link 20 29,731,828 29,768,656 RGD:1624291
G Coro1a coronin 1A JBrowse link 1 198,123,883 198,128,890 RGD:1624291
RGD:1600115
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
RGD:1600115
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:1624291
G Foxn1 forkhead box N1 JBrowse link 10 65,621,142 65,634,666 RGD:1624291
G Gimap5 GTPase, IMAP family member 5 JBrowse link 4 78,377,228 78,386,683 RGD:1303374
G Gpr174 G protein-coupled receptor 174 JBrowse link X 78,358,347 78,399,944 RGD:1624291
RGD:1600115
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:1624291
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1624291
RGD:13792537
RGD:1600115
G Nckap1l NCK associated protein 1 like JBrowse link 7 145,068,239 145,113,507 RGD:1624291
RGD:1600115
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
RGD:1600115
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma JBrowse link 6 76,056,585 76,079,755 RGD:1624291
RGD:13792537
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1624291
RGD:1600115
G Rag1 recombination activating 1 JBrowse link 3 91,206,394 91,217,491 RGD:1624291
RGD:1600115
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link 3 21,621,976 21,676,789 RGD:1624291
RGD:1600115
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:1624291
RGD:1600115
G Sit1 signaling threshold regulating transmembrane adaptor 1 JBrowse link 5 58,985,912 58,987,538 RGD:1600115
G Slc39a3 solute carrier family 39 member 3 JBrowse link 7 11,545,073 11,551,074 RGD:1624291
RGD:1600115
G Slc46a2 solute carrier family 46, member 2 JBrowse link 5 77,165,463 77,174,177 RGD:1624291
RGD:1600115
G Spns2 sphingolipid transporter 2 JBrowse link 10 59,010,428 59,049,482 RGD:1624291
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1624291
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:1624291
RGD:1600115
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
G Zc3h8 zinc finger CCCH type containing 8 JBrowse link 3 121,471,836 121,488,528 RGD:1624291
RGD:1600115
T cell homeostatic proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17883
    immune system process 2295
      leukocyte homeostasis 110
        basophil homeostasis 1
        dendritic cell homeostasis 2
        eosinophil homeostasis 1
        lymphocyte homeostasis + 78
        macrophage homeostasis 1
        mast cell homeostasis + 5
        monocyte homeostasis 2
        neutrophil homeostasis + 24
Path 2
Term Annotations click to browse term
  biological_process 17883
    biological regulation 12594
      regulation of biological quality 4113
        homeostatic process 1960
          homeostasis of number of cells 318
            leukocyte homeostasis 110
              basophil homeostasis 1
              dendritic cell homeostasis 2
              eosinophil homeostasis 1
              lymphocyte homeostasis + 78
              macrophage homeostasis 1
              mast cell homeostasis + 5
              monocyte homeostasis 2
              neutrophil homeostasis + 24
paths to the root