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ONTOLOGY REPORT - ANNOTATIONS


Term:natural killer cell differentiation
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Accession:GO:0001779 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK cell differentiation
 related_synonym: natural killer cell development


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natural killer cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase ISO
IBA
MGI:MGI:104294|MGI:MGI:96965 (MGI:MGI:3662985|PMID:16751775)
PMID:21873635
RGD PMID:16751775, PMID:21873635 MGI:MGI:3662985, RGD:13792537 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 ISO MGI:MGI:2137552 (MGI:MGI:5604339|PMID:24855001) RGD PMID:24855001 MGI:MGI:5604339 NCBI chr 6:72,509,658...72,596,285
Ensembl chr 6:72,510,255...72,596,446
JBrowse link
G Id2 inhibitor of DNA binding 2 ISO MGI:MGI:2384134|MGI:MGI:98510 (MGI:MGI:3759740|PMID:17452521) RGD PMID:17452521 MGI:MGI:3759740 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 ISO MGI:MGI:2158738 (MGI:MGI:68746|PMID:7923373) RGD PMID:7923373 MGI:MGI:68746 NCBI chr14:91,782,281...91,867,828
Ensembl chr14:91,782,354...91,867,424
JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 ISO MGI:MGI:2177774 (MGI:MGI:3505799|PMID:15499555) RGD PMID:15499555 MGI:MGI:3505799 NCBI chr 5:58,149,150...58,159,072
Ensembl chr 5:58,151,985...58,159,072
JBrowse link
G Kat7 lysine acetyltransferase 7 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:6393224|PMID:27733580)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:27733580 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6393224 NCBI chr10:83,095,067...83,128,342
Ensembl chr10:83,095,068...83,128,297
JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase ISO MGI:MGI:104294|MGI:MGI:1347244 (MGI:MGI:3662985|PMID:16751775) RGD PMID:16751775 MGI:MGI:3662985 NCBI chr 3:121,235,230...121,340,932
Ensembl chr 3:121,235,119...121,342,444
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C ISO (MGI:MGI:3521537|PMID:15557316) RGD PMID:15557316 MGI:MGI:3521537 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G Rabl3 RAB, member of RAS oncogene family-like 3 ISO (MGI:MGI:6405642|PMID:32220963) RGD PMID:32220963 MGI:MGI:6405642 NCBI chr11:66,049,635...66,078,669
Ensembl chr11:66,049,635...66,078,669
JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 ISO (MGI:MGI:3763993|PMID:18031695) RGD PMID:18031695 MGI:MGI:3763993 NCBI chr13:90,184,545...90,219,170
Ensembl chr13:90,184,569...90,219,217
JBrowse link
G Slamf6 SLAM family member 6 ISO (MGI:MGI:3763993|PMID:18031695) RGD PMID:18031695 MGI:MGI:3763993 NCBI chr13:90,300,160...90,321,781
Ensembl chr13:90,301,006...90,322,457
JBrowse link
G Sp3 Sp3 transcription factor ISO MGI:MGI:2182438 (MGI:MGI:2670314|PMID:12676787) RGD PMID:12676787 MGI:MGI:2670314 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO MGI:MGI:103035 (MGI:MGI:1332382|PMID:10072077) RGD PMID:10072077 MGI:MGI:1332382 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO
IEA
MGI:MGI:103036 (MGI:MGI:1332382|PMID:10072077)
GO_REF:0000107
RGD
Ensembl
PMID:10072077 GO_REF:0000107, MGI:MGI:1332382 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Tcf3 transcription factor 3 ISO MGI:MGI:96397 (MGI:MGI:3759740|PMID:17452521) RGD PMID:17452521 MGI:MGI:3759740 NCBI chr 7:12,146,642...12,168,400
Ensembl chr 7:12,144,162...12,168,410
JBrowse link
G Tox thymocyte selection-associated high mobility group box ISO (PMID:21126536) RGD PMID:21126536 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator ISO MGI:MGI:103014|MGI:MGI:3706236 (MGI:MGI:3703651|PMID:17318811) RGD PMID:17318811 MGI:MGI:3703651 NCBI chr 8:116,318,963...116,322,181
Ensembl chr 8:116,318,963...116,322,181
JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase ISO
IEA
MGI:MGI:1347244|MGI:MGI:96965 (MGI:MGI:3662985|PMID:16751775)
GO_REF:0000107
RGD
Ensembl
PMID:16751775 GO_REF:0000107, MGI:MGI:3662985 NCBI chr 3:111,597,102...111,616,142
Ensembl chr 3:111,597,102...111,616,142
JBrowse link
G Zfp683 zinc finger protein 683 ISO MGI:MGI:4276801 (MGI:MGI:5437828|PMID:22885984) RGD PMID:22885984 MGI:MGI:5437828 NCBI chr 5:152,280,982...152,288,208 JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pglyrp1 peptidoglycan recognition protein 1 ISO
IEA
MGI:MGI:2670590 (MGI:MGI:5297102|PMID:20709292)
GO_REF:0000107
RGD
Ensembl
PMID:20709292 GO_REF:0000107, MGI:MGI:5297102 NCBI chr 1:79,790,879...79,796,064
Ensembl chr 1:79,790,705...79,796,111
JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 ISO MGI:MGI:5297105 (MGI:MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:MGI:5297102 NCBI chr 7:14,426,481...14,435,987
Ensembl chr 7:14,429,701...14,435,967
JBrowse link
G Pglyrp3 peptidoglycan recognition protein 3 ISO MGI:MGI:5297106 (MGI:MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:MGI:5297102 NCBI chr 2:191,903,626...192,264,872
Ensembl chr 2:192,253,629...192,264,840
JBrowse link
G Pglyrp4 peptidoglycan recognition protein 4 ISO MGI:MGI:5297107 (MGI:MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:MGI:5297102 NCBI chr 2:190,125,655...190,204,230
Ensembl chr 2:190,125,693...190,148,265
JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase ISO (PMID:18840707) RGD PMID:18840707 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand ISO MGI:MGI:2158499 (MGI:MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:MGI:3701546 NCBI chr 1:101,126,006...101,131,413
Ensembl chr 1:101,124,479...101,131,413
JBrowse link
G Gas6 growth arrest specific 6 ISO
ISS
(PMID:18840707)
GO_REF:0000024
RGD
UniProt
PMID:18840707 GO_REF:0000024 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Il15 interleukin 15 ISO MGI:MGI:1931086|MGI:MGI:2136897 (MGI:MGI:3701546|PMID:14607906), (MGI:MGI:3703651|PMID:17318811) RGD PMID:14607906, PMID:17318811 MGI:MGI:3701546, MGI:MGI:3703651 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il15ra interleukin 15 receptor subunit alpha ISO MGI:MGI:1934016 (MGI:MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:MGI:3701546 NCBI chr17:70,451,861...70,481,838
Ensembl chr17:70,451,411...70,481,750
JBrowse link
G Il21 interleukin 21 ISO (MGI:MGI:3028812|PMID:14764669) RGD PMID:14764669 MGI:MGI:3028812 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 ISO (MGI:MGI:5302428|PMID:21957144) RGD PMID:21957144 MGI:MGI:5302428 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO MGI:MGI:1857249 (MGI:MGI:3655409|PMID:9841920) RGD PMID:9841920 MGI:MGI:3655409 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO
IEA
MGI:MGI:2181592 (MGI:MGI:3655409|PMID:9841920)
GO_REF:0000107
RGD
Ensembl
PMID:9841920 GO_REF:0000107, MGI:MGI:3655409 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Tox thymocyte selection-associated high mobility group box ISO MGI:MGI:3773716 (MGI:MGI:4834966|PMID:20818394) RGD PMID:20818394 MGI:MGI:4834966 NCBI chr 5:19,892,698...20,189,721
Ensembl chr 5:19,892,698...20,189,721
JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 ISO (MGI:MGI:5446979|PMID:22753936) RGD PMID:22753936 MGI:MGI:5446979 NCBI chr 6:99,401,775...99,425,739
Ensembl chr 6:99,402,360...99,424,019
JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 ISO (MGI:MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:MGI:5491117 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Prdm1 PR/SET domain 1 ISO (MGI:MGI:5779429|PMID:27102484) RGD PMID:27102484 MGI:MGI:5779429 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
JBrowse link
G Zfp683 zinc finger protein 683 ISO (MGI:MGI:5779429|PMID:27102484) RGD PMID:27102484 MGI:MGI:5779429 NCBI chr 5:152,280,982...152,288,208 JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp683 zinc finger protein 683 ISO (MGI:MGI:5437828|PMID:22885984) RGD PMID:22885984 MGI:MGI:5437828 NCBI chr 5:152,280,982...152,288,208 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    immune system process 2844
      leukocyte activation 1058
        lymphocyte activation 873
          lymphocyte differentiation 409
            natural killer cell differentiation 32
              natural killer cell differentiation involved in immune response + 5
              negative regulation of natural killer cell differentiation + 4
              positive regulation of natural killer cell differentiation + 11
              regulation of natural killer cell differentiation + 18
Path 2
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            immune system development 1073
              hematopoietic or lymphoid organ development 1008
                hemopoiesis 956
                  leukocyte differentiation 597
                    lymphocyte differentiation 409
                      natural killer cell differentiation 32
                        natural killer cell differentiation involved in immune response + 5
                        negative regulation of natural killer cell differentiation + 4
                        positive regulation of natural killer cell differentiation + 11
                        regulation of natural killer cell differentiation + 18
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.