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ONTOLOGY REPORT - ANNOTATIONS


Term:antibody-dependent cellular cytotoxicity
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Accession:GO:0001788 term browser browse the term
Definition:Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
Synonyms:exact_synonym: ADCC;   antibody dependent cell death;   antibody-dependent cell killing;   type VI hypersensitivity
 xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity;   Wikipedia:Antibody-dependent_cellular_cytotoxicity


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antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) JBrowse link 17 59,073,139 59,102,023 RGD:13508589

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Path 1
Term Annotations click to browse term
  biological_process 14453
    cellular process 13629
      cell killing 76
        leukocyte mediated cytotoxicity 55
          antibody-dependent cellular cytotoxicity 1
            negative regulation of antibody-dependent cellular cytotoxicity 0
            positive regulation of antibody-dependent cellular cytotoxicity 0
            regulation of antibody-dependent cellular cytotoxicity + 0
Path 2
Term Annotations click to browse term
  biological_process 14453
    response to stimulus 6259
      response to stress 2249
        defense response 810
          inflammatory response 386
            acute inflammatory response 49
              acute inflammatory response to antigenic stimulus 11
                hypersensitivity 7
                  type II hypersensitivity 2
                    type IIa hypersensitivity 2
                      antibody-dependent cellular cytotoxicity 1
                        negative regulation of antibody-dependent cellular cytotoxicity 0
                        positive regulation of antibody-dependent cellular cytotoxicity 0
                        regulation of antibody-dependent cellular cytotoxicity + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.