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ONTOLOGY REPORT - ANNOTATIONS


Term:antibody-dependent cellular cytotoxicity
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Accession:GO:0001788 term browser browse the term
Definition:Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
Synonyms:exact_synonym: ADCC;   antibody dependent cell death;   antibody-dependent cell killing;   type VI hypersensitivity
 xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity;   Wikipedia:Antibody-dependent_cellular_cytotoxicity


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antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr1a Fc fragment of IgG receptor Ia JBrowse link 2 198,430,536 198,439,453 RGD:1624291
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:1624291
G Ighg1 immunoglobulin heavy constant gamma 1 JBrowse link 6 139,140,572 139,784,388 RGD:1624291
positive regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:2293335

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    cellular process 18362
      cell killing 227
        leukocyte mediated cytotoxicity 136
          antibody-dependent cellular cytotoxicity 4
            negative regulation of antibody-dependent cellular cytotoxicity 0
            positive regulation of antibody-dependent cellular cytotoxicity 1
            regulation of antibody-dependent cellular cytotoxicity + 2
Path 2
Term Annotations click to browse term
  biological_process 19578
    response to stimulus 10490
      response to stress 3960
        defense response 1593
          inflammatory response 715
            acute inflammatory response 128
              acute inflammatory response to antigenic stimulus 36
                hypersensitivity 17
                  type II hypersensitivity 6
                    type IIa hypersensitivity 6
                      antibody-dependent cellular cytotoxicity 4
                        negative regulation of antibody-dependent cellular cytotoxicity 0
                        positive regulation of antibody-dependent cellular cytotoxicity 1
                        regulation of antibody-dependent cellular cytotoxicity + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.