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ONTOLOGY REPORT - ANNOTATIONS


Term:type IIa hypersensitivity
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Accession:GO:0001794 term browser browse the term
Definition:An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell.
Comment:Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity.


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antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr1a Fc fragment of IgG receptor Ia JBrowse link 2 198,430,536 198,439,453 RGD:1624291
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:1624291
G Ighg1 immunoglobulin heavy constant gamma 1 JBrowse link 6 139,140,572 139,784,388 RGD:1624291
positive regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
positive regulation of type IIa hypersensitivity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:1624291
RGD:1600115
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link 13 89,601,894 89,606,326 RGD:1624291
G Fcgr1a Fc fragment of IgG receptor Ia JBrowse link 2 198,430,536 198,439,453 RGD:1624291
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:1624291
G Ighg1 immunoglobulin heavy constant gamma 1 JBrowse link 6 139,140,572 139,784,388 RGD:1624291
regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:2293335

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    immune system process 2693
      immune effector process 861
        leukocyte mediated immunity 502
          myeloid leukocyte mediated immunity 117
            type II hypersensitivity 6
              type IIa hypersensitivity 6
                antibody-dependent cellular cytotoxicity + 4
                negative regulation of type IIa hypersensitivity + 0
                positive regulation of type IIa hypersensitivity + 6
                regulation of type IIa hypersensitivity + 6
Path 2
Term Annotations click to browse term
  biological_process 19578
    response to stimulus 10490
      response to stress 3960
        defense response 1593
          inflammatory response 715
            inflammatory response to antigenic stimulus 85
              acute inflammatory response to antigenic stimulus 36
                hypersensitivity 17
                  type II hypersensitivity 6
                    type IIa hypersensitivity 6
                      antibody-dependent cellular cytotoxicity + 4
                      negative regulation of type IIa hypersensitivity + 0
                      positive regulation of type IIa hypersensitivity + 6
                      regulation of type IIa hypersensitivity + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.