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ONTOLOGY REPORT - ANNOTATIONS


Term:serotonin secretion
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Accession:GO:0001820 term browser browse the term
Definition:The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.
Synonyms:exact_synonym: 5-HT secretion;   5-hydroxytryptamine secretion
 related_synonym: serotonin release


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serotonin secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcer1a Fc fragment of IgE receptor Ia ISO MGI:2383982 (MGI:85068|PMID:9000133), (MGI:86632|PMID:8252632) RGD PMID:8252632, PMID:9000133 MGI:85068, MGI:86632 NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa ISO (MGI:78617|PMID:8552190) RGD PMID:8552190 MGI:78617 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link
G Syk spleen associated tyrosine kinase ISO MGI:2384078 (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
negative regulation of serotonin secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule ISO (MGI:3721168|PMID:12874256) RGD PMID:12874256 MGI:3721168 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
G Cnr1 cannabinoid receptor 1 IMP PMID:30217553 CACAO PMID:30217553 RGD:15023474 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Hrh3 histamine receptor H3 IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:15470136, PMID:21873635 RGD:1626430, RGD:13792537 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISS
ISO
GO_REF:0000024
(MGI:1098377|PMID:9349547)
UniProt
RGD
PMID:9349547 GO_REF:0000024, MGI:1098377 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP RGD PMID:15260125 RGD:6480684 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Maob monoamine oxidase B IMP RGD PMID:12175458 RGD:2316765 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
positive regulation of serotonin secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:20655906 RGD:5130946 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362
JBrowse link
G Lgals3 galectin 3 IDA RGD PMID:8347574 RGD:9685207 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Slc6a4 solute carrier family 6 member 4 IMP RGD PMID:25261262 RGD:11532763 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
regulation of serotonin secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone IDA RGD PMID:21947356 RGD:5507821 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISS
ISO
GO_REF:0000024
(MGI:1314969|PMID:9826725)
UniProt
RGD
PMID:9826725 GO_REF:0000024, MGI:1314969 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
serotonin secretion by mast cell term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule ISO (MGI:3721168|PMID:12874256) RGD PMID:12874256 MGI:3721168 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
serotonin secretion by platelet term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcer1g Fc fragment of IgE receptor Ig ISO (MGI:87668|PMID:9171347) RGD PMID:9171347 MGI:87668 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G P2rx1 purinergic receptor P2X 1 ISO MGI:2181608 (MGI:2671726|PMID:12913094) RGD PMID:12913094 MGI:2671726 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Syk spleen associated tyrosine kinase IEA
ISO
ISS
GO_REF:0000107
(MGI:87668|PMID:9171347)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:9171347 GO_REF:0000024, GO_REF:0000107, MGI:87668 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
serotonin secretion, neurotransmission term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xbp1 X-box binding protein 1 IDA RGD PMID:16889758 RGD:2326003 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      cell-cell signaling 1727
        signal release 617
          serotonin secretion 17
            negative regulation of serotonin secretion 6
            positive regulation of serotonin secretion 3
            regulation of serotonin secretion + 11
            serotonin secretion involved in inflammatory response + 4
            serotonin secretion, neurotransmission 1
Path 2
Term Annotations click to browse term
  biological_process 20020
    localization 6478
      establishment of localization 4886
        transport 4734
          ion transport 3500
            anion transport 2681
              organic substance transport 2558
                monoamine transport 106
                  serotonin transport 27
                    serotonin secretion 17
                      negative regulation of serotonin secretion 6
                      positive regulation of serotonin secretion 3
                      regulation of serotonin secretion + 11
                      serotonin secretion involved in inflammatory response + 4
                      serotonin secretion, neurotransmission 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.