Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:release of cytochrome c from mitochondria
go back to main search page
Accession:GO:0001836 term browser browse the term
Definition:The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
Comment:The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011.


show annotations for term's descendants           Sort by:
 
release of cytochrome c from mitochondria term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha ISO MGI:1856098 (MGI:3760368|PMID:11311799) RGD PMID:11311799 MGI:3760368 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Bad BCL2-associated agonist of cell death IBA
ISO
PMID:21873635
MGI:3029528 (MGI:3029504|PMID:12431371)
RGD PMID:12431371, PMID:21873635 MGI:3029504, RGD:13792537 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 IMP
ISO
ISS
positive regulation
(MGI:5009197|PMID:10950869)
UniProtKB:O08734 (PMID:16199525), (PMID:21041309), (PMID:9843949)
GO_REF:0000024
RGD
HGNC
PMID:9843949, PMID:10950869, PMID:16199525, PMID:21041309, PMID:18252800 GO_REF:0000024, MGI:5009197, RGD:2313987 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEA
ISO
IDA
IBA
GO_REF:0000107
MGI:108093|MGI:98834 (MGI:1203837|PMID:9560217), (MGI:2677915|PMID:12925707), (MGI:2681362|PMID:14623868), (MGI:3028818|PMID:14614769), (MGI:3042308|PMID:14963330), (MGI:3688960|PMID:17052454)
PMID:21873635
(PMID:16199525), (PMID:17052454), (PMID:9843949)
Ensembl
RGD
PMID:9560217, PMID:9843949, PMID:12925707, PMID:14614769, PMID:14623868, PMID:14963330, PMID:16199525, PMID:17052454, PMID:10724126, PMID:21873635 GO_REF:0000107, MGI:1203837, MGI:2677915, MGI:2681362, MGI:3028818, MGI:3042308, MGI:3688960, RGD:14394498, RGD:13792537 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 ISO
IBA
(PMID:11463392)
PMID:21873635
RGD PMID:11463392, PMID:21873635 RGD:13792537 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator IEA
ISO
ISS
GO_REF:0000107
(MGI:3700463|PMID:9843949)
Ensembl
RGD
PMID:9843949, PMID:9843949 GO_REF:0000107, MGI:3700463, RGD:8554139 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 ISO (PMID:9843949)
MGI:99702 (MGI:3688960|PMID:17052454)
RGD PMID:9843949, PMID:17052454 MGI:3688960 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist IDA
ISO
MGI:2158671 (MGI:2137769|PMID:11369777), (MGI:4940333|PMID:9873064), (MGI:5619478|PMID:18084238)
(PMID:17052454)
RGD PMID:9873064, PMID:11369777, PMID:17052454, PMID:18084238, PMID:18252800 MGI:2137769, MGI:4940333, MGI:5619478, RGD:2313987 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bok BCL2 family apoptosis regulator BOK ISO (PMID:27505430) RGD PMID:27505430 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Cck cholecystokinin IDA RGD PMID:11964411 RGD:625521 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Dnm1l dynamin 1-like ISO (PMID:20850011) RGD PMID:20850011 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Fis1 fission, mitochondrial 1 ISO (PMID:19864424) RGD PMID:19864424 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Ggct gamma-glutamyl cyclotransferase ISO (PMID:16765912) RGD PMID:16765912 NCBI chr 4:85,186,644...85,192,857
Ensembl chr 4:85,186,644...85,192,834
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IMP induces release following removal of NGF from sympathetic neurons RGD PMID:11301023 RGD:2290592 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:15504737 RGD:2298783 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mff mitochondrial fission factor ISO (PMID:18353969) RGD PMID:18353969 NCBI chr 9:88,490,280...88,518,517
Ensembl chr 9:88,493,593...88,517,827
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO MGI:2678372 (MGI:2675761|PMID:12952892), (MGI:5009174|PMID:14699081) RGD PMID:12952892, PMID:14699081 MGI:2675761, MGI:5009174 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Sfn stratifin ISO (PMID:11574543) RGD PMID:11574543 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Sod2 superoxide dismutase 2 ISO MGI:1857344|MGI:1857480 (MGI:3654558|PMID:10212301), (MGI:3691744|PMID:15642323) RGD PMID:10212301, PMID:15642323 MGI:3654558, MGI:3691744 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 ISO (PMID:15044455) RGD PMID:15044455 NCBI chr 1:85,470,810...85,480,813
Ensembl chr 1:85,470,831...85,480,407
JBrowse link
G Tp53 tumor protein p53 ISO MGI:99702 (MGI:3042308|PMID:14963330), (MGI:3574697|PMID:15483136) RGD PMID:14963330, PMID:15483136 MGI:3042308, MGI:3574697 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp73 tumor protein p73 ISO (MGI:3574697|PMID:15483136) RGD PMID:15483136 MGI:3574697 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
negative regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISS
ISO
GO_REF:0000024
(MGI:5294538|PMID:18977203)
UniProt
RGD
PMID:18977203 GO_REF:0000024, MGI:5294538 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arrb2 arrestin, beta 2 IMP RGD PMID:19171933 RGD:5510006 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Avp arginine vasopressin ISO (PMID:18402937) RGD PMID:18402937 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bcl2l2 Bcl2-like 2 IDA RGD PMID:10724126 RGD:14394498 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164
JBrowse link
G Fxn frataxin ISO
IEA
(PMID:16608849)
GO_REF:0000107
RGD
Ensembl
PMID:16608849 GO_REF:0000107 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834
JBrowse link
G Ghitm growth hormone inducible transmembrane protein ISO (PMID:18417609) RGD PMID:18417609 NCBI chr16:14,370,269...14,382,647
Ensembl chr16:14,371,531...14,382,641
JBrowse link
G Gpx1 glutathione peroxidase 1 ISO
IEA
(PMID:12221075)
GO_REF:0000107
RGD
Ensembl
PMID:12221075 GO_REF:0000107 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hgf hepatocyte growth factor ISO (PMID:20655899) RGD PMID:20655899 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A ISO (MGI:5306879|PMID:21856340) RGD PMID:21856340 MGI:5306879 NCBI chr 8:130,482,492...130,491,888
Ensembl chr 8:130,482,493...130,491,998
JBrowse link
G Igf1 insulin-like growth factor 1 ISS
ISO
GO_REF:0000024
(MGI:5294538|PMID:18977203)
UniProt
RGD
PMID:18977203 GO_REF:0000024, MGI:5294538 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Lmna lamin A/C IEA
ISO
GO_REF:0000107
(MGI:4879057|PMID:21151901)
Ensembl
RGD
PMID:21151901 GO_REF:0000107, MGI:4879057 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:18006463 RGD:12738362 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Nol3 nucleolar protein 3 IDA
IEA
ISO
PMID:10590251
GO_REF:0000107
(PMID:15004034)
Ensembl
RGD
PMID:15004034, PMID:10590251 GO_REF:0000107, RGD:10047155 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase ISO
ISS
(PMID:21149567)
(MGI:3692706|PMID:16839884)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:16839884, PMID:21149567 GO_REF:0000024, MGI:3692706 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Pam16 presequence translocase associated motor 16 IDA RGD PMID:24069394 RGD:13462066 NCBI chr10:11,146,359...11,153,936
Ensembl chr10:11,146,359...11,153,936
JBrowse link
G Parl presenilin associated, rhomboid-like IEA
ISO
ISS
GO_REF:0000107
(MGI:3692706|PMID:16839884)
GO_REF:0000024
Ensembl
RGD
ParkinsonsUK-UCL
PMID:16839884 GO_REF:0000024, GO_REF:0000107, MGI:3692706 NCBI chr11:84,517,368...84,544,463
Ensembl chr11:84,517,368...84,544,462
JBrowse link
G Ppif peptidylprolyl isomerase F ISO
ISS
(PMID:19228691)
GO_REF:0000024
RGD
UniProt
PMID:19228691 GO_REF:0000024 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Prelid1 PRELI domain containing 1 ISO (PMID:23931759) RGD PMID:23931759 NCBI chr17:9,834,245...9,837,285
Ensembl chr17:9,834,242...9,837,303
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISS
ISO
GO_REF:0000024
(PMID:19880420), (PMID:23453807)
ParkinsonsUK-UCL
RGD
PMID:19880420, PMID:23453807 GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 ISO
IEA
ISS
(PMID:19729910)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19729910 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:112,323,188...112,328,642
Ensembl chr  X:112,323,187...112,328,642
JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 ISO (PMID:23931759) RGD PMID:23931759 NCBI chr12:46,987,404...46,989,906
Ensembl chr12:46,987,404...46,989,897
Ensembl chr12:46,987,404...46,989,897
JBrowse link
positive regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC130253.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr10:37,582,706...37,583,167 JBrowse link
G Bad BCL2-associated agonist of cell death ISO (PMID:17289999) RGD PMID:17289999 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 IMP RGD PMID:12485416 RGD:2317097 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEA
ISO
ISS
GO_REF:0000107
(PMID:14963330), (PMID:21262771)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:14963330, PMID:21262771 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 IBA
ISO
PMID:21873635
UniProtKB:P70444 (PMID:21041309)
RGD PMID:21041309, PMID:21873635 RGD:13792537 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2l11 BCL2 like 11 ISO UniProtKB:P70444 (PMID:17289999), (PMID:21041309) RGD PMID:17289999, PMID:21041309 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bid BH3 interacting domain death agonist ISO
IBA
UniProtKB:P70444 (PMID:17289999), (PMID:21041309), (PMID:21262771)
UniProtKB:O08734|UniProtKB:P70444 (MGI:5009197|PMID:10950869), (MGI:5009775|PMID:21041309)
PMID:21873635
RGD PMID:10950869, PMID:17289999, PMID:21041309, PMID:21262771, PMID:21873635 MGI:5009197, MGI:5009775, RGD:13792537 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bik BCL2-interacting killer ISO (PMID:21041309) RGD PMID:21041309 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Bmf Bcl2 modifying factor ISO UniProtKB:P70444 (MGI:5009775|PMID:21041309) RGD PMID:21041309 MGI:5009775 NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO (PMID:20436456) RGD PMID:20436456 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Cideb cell death-inducing DFFA-like effector b ISO (PMID:12595532) RGD PMID:12595532 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244
JBrowse link
G Dnm1l dynamin 1-like ISO (PMID:21149567) RGD PMID:21149567 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Fam162a family with sequence similarity 162, member A ISO
IBA
ISS
(PMID:15082785)
(MGI:5319617|PMID:15082785)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:15082785, PMID:21873635 GO_REF:0000024, MGI:5319617, RGD:13792537 NCBI chr11:67,618,683...67,646,253
Ensembl chr11:67,618,625...67,646,253
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IDA PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Hrk harakiri, BCL2 interacting protein ISO (PMID:21041309) RGD PMID:21041309 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Mff mitochondrial fission factor ISO (PMID:21149567) RGD PMID:21149567 NCBI chr 9:88,490,280...88,518,517
Ensembl chr 9:88,493,593...88,517,827
JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor ISO
IBA
ISS
(PMID:18852119)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:18852119, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:196,392,936...196,402,106
Ensembl chr 2:196,392,938...196,402,106
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO
IEA
(PMID:22984561)
GO_REF:0000107
RGD
Ensembl
PMID:22984561 GO_REF:0000107 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Moap1 modulator of apoptosis 1 ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:126,620,597...126,622,532
Ensembl chr 6:126,620,602...126,622,532
JBrowse link
G Pdcd5 programmed cell death 5 ISO (PMID:16374546) RGD PMID:16374546 NCBI chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
JBrowse link
G Pink1 PTEN induced kinase 1 ISO (PMID:19880420) RGD PMID:19880420 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Pla2g6 phospholipase A2 group VI IDA RGD PMID:18936091 RGD:6482750 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO
IEA
(PMID:22984561)
GO_REF:0000107
RGD
Ensembl
PMID:22984561 GO_REF:0000107 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO (PMID:14500711), (PMID:14699081), (PMID:15705586), (PMID:17289999) RGD PMID:14500711, PMID:14699081, PMID:15705586, PMID:17289999 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Ppif peptidylprolyl isomerase F ISS
ISO
GO_REF:0000024
(MGI:3575990|PMID:15800627)
UniProt
RGD
PMID:15800627 GO_REF:0000024, MGI:3575990 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G RGD1306484 similar to growth and transformation-dependent protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:37,582,678...37,583,232 JBrowse link
G Tnfsf10 TNF superfamily member 10 ISO (PMID:22266862) RGD PMID:22266862 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:14963330) RGD PMID:14963330 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Wdr35 WD repeat domain 35 IMP RGD PMID:23289926 RGD:11553920 NCBI chr 6:34,094,291...34,152,048
Ensembl chr 6:34,094,306...34,151,622
JBrowse link
regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plscr3 phospholipid scramblase 3 ISO
ISS
(PMID:14573790), (PMID:18358005)
GO_REF:0000024
RGD
UniProt
PMID:14573790, PMID:18358005 GO_REF:0000024 NCBI chr10:56,452,632...56,458,390
Ensembl chr10:56,453,877...56,458,390
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        apoptotic signaling pathway 630
          release of cytochrome c from mitochondria 64
            negative regulation of release of cytochrome c from mitochondria 21
            positive regulation of release of cytochrome c from mitochondria 30
            regulation of release of cytochrome c from mitochondria + 51
Path 2
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          organelle organization 4101
            mitochondrion organization 547
              apoptotic mitochondrial changes 120
                release of cytochrome c from mitochondria 64
                  negative regulation of release of cytochrome c from mitochondria 21
                  positive regulation of release of cytochrome c from mitochondria 30
                  regulation of release of cytochrome c from mitochondria + 51
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.