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ONTOLOGY REPORT - ANNOTATIONS


Term:NK T cell differentiation
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Accession:GO:0001865 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a NK T cell.
Comment:Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK T lymphocyte differentiation;   NKT cell differentiation;   NT cell differentiation;   natural T cell differentiation;   natural killer T cell differentiation
 related_synonym: NK T cell development


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NK T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd1d1 CD1d1 molecule JBrowse link 2 186,330,298 186,333,805 RGD:1624291
G Itk IL2-inducible T-cell kinase JBrowse link 10 31,431,820 31,493,413 RGD:1624291
RGD:13792537
G Psap prosaposin JBrowse link 20 29,831,302 29,856,876 RGD:1600115
RGD:1624291
G Txk TXK tyrosine kinase JBrowse link 14 38,029,809 38,085,822 RGD:1624291
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291
NK T cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tox thymocyte selection-associated high mobility group box JBrowse link 5 19,892,698 20,189,721 RGD:1624291
positive regulation of NK T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap3b1 adaptor related protein complex 3 subunit beta 1 JBrowse link 2 24,022,815 24,227,522 RGD:1624291
G Ap3d1 adaptor related protein complex 3 subunit delta 1 JBrowse link 7 11,838,639 11,873,992 RGD:1624291
G Cd1d1 CD1d1 molecule JBrowse link 2 186,330,298 186,333,805 RGD:1624291
G Ikzf1 IKAROS family zinc finger 1 JBrowse link 14 91,782,281 91,867,828 RGD:1624291
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1624291
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:1624291
regulation of NK T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prdm1 PR/SET domain 1 JBrowse link 20 49,464,921 49,556,623 RGD:1624291
G Zfp683 zinc finger protein 683 JBrowse link 5 152,280,982 152,288,208 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    immune system process 2692
      leukocyte activation 1008
        lymphocyte activation 828
          lymphocyte differentiation 392
            T cell differentiation 279
              alpha-beta T cell differentiation 119
                NK T cell differentiation 13
                  NK T cell lineage commitment 1
                  negative regulation of NK T cell differentiation 0
                  positive regulation of NK T cell differentiation 6
                  regulation of NK T cell differentiation + 8
Path 2
Term Annotations click to browse term
  biological_process 19576
    developmental process 6694
      anatomical structure development 6153
        multicellular organism development 5621
          system development 5156
            immune system development 1046
              hematopoietic or lymphoid organ development 982
                hemopoiesis 930
                  leukocyte differentiation 575
                    lymphocyte differentiation 392
                      T cell differentiation 279
                        alpha-beta T cell differentiation 119
                          NK T cell differentiation 13
                            NK T cell lineage commitment 1
                            negative regulation of NK T cell differentiation 0
                            positive regulation of NK T cell differentiation 6
                            regulation of NK T cell differentiation + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.