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ONTOLOGY REPORT - ANNOTATIONS


Term:complement activation, lectin pathway
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Accession:GO:0001867 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Comment:Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
Synonyms:exact_synonym: complement cascade, lectin pathway


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complement activation, lectin pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07006691.1 IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 1:248,428,099...248,463,139 JBrowse link
G Cd69 Cd69 molecule TAS RGD PMID:11034393, PMID:15506986 RGD:1354527, RGD:1354528 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Colec11 collectin sub-family member 11 ISO (PMID:25912189) RGD PMID:25912189 NCBI chr 6:47,857,767...47,889,961
Ensembl chr 6:47,857,771...47,890,033
JBrowse link
G Fcna ficolin A ISO
IBA
(MGI:MGI:5473786|PMID:16328467)
PMID:21873635
(PMID:11907111)
RGD PMID:11907111, PMID:16328467, PMID:21873635 MGI:MGI:5473786, RGD:13792537 NCBI chr 3:2,850,006...2,853,230
Ensembl chr 3:2,849,984...2,853,272
JBrowse link
G Fcnb ficolin B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:6,617,816...6,626,193
Ensembl chr 3:6,617,751...6,626,284
JBrowse link
G Krt1 keratin 1 IEA
ISO
GO_REF:0000107
UniProtKB:P11226 (PMID:11549596)
Ensembl
RGD
PMID:11549596 GO_REF:0000107 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G LOC102553715 microfibril-associated glycoprotein 4-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:49,000,914...49,003,935
Ensembl chr10:49,000,973...49,003,931
JBrowse link
G Masp1 mannan-binding lectin serine peptidase 1 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(MGI:MGI:3789229|PMID:18424734)
(PMID:17182967)
Ensembl
UniProt
RGD
PMID:17182967, PMID:18424734, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3789229, RGD:13792537 NCBI chr11:80,736,424...80,806,278
Ensembl chr11:80,736,576...80,803,382
JBrowse link
G Masp2 mannan-binding lectin serine peptidase 2 ISO
IBA
IEA
(MGI:MGI:5473786|PMID:16328467)
PMID:21873635
(PMID:17182967), (PMID:9087411)
GO_REF:0000002
GO_REF:0000107
RGD
InterPro
Ensembl
PMID:9087411, PMID:16328467, PMID:17182967, PMID:21873635 GO_REF:0000002, GO_REF:0000107, MGI:MGI:5473786, RGD:13792537 NCBI chr 5:165,415,105...165,429,857
Ensembl chr 5:165,415,136...165,430,054
JBrowse link
G Mbl1 mannose binding lectin 1 IDA
ISO
MGI:MGI:96924 (MGI:MGI:3577322|PMID:15148336) RGD PMID:15148336, PMID:16272342 MGI:MGI:3577322, RGD:1582134 NCBI chr16:18,736,154...18,742,193
Ensembl chr16:18,736,154...18,742,193
JBrowse link
G Mbl2 mannose binding lectin 2 ISO MGI:MGI:3577339|MGI:MGI:96923 (MGI:MGI:3577322|PMID:15148336)
UniProtKB:P04264 (PMID:11549596), (PMID:15148336)
RGD PMID:11549596, PMID:15148336 MGI:MGI:3577322 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mfap4 microfibril associated protein 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:47,765,463...47,768,484
Ensembl chr10:47,765,432...47,768,483
JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO (PMID:12538697) RGD PMID:12538697 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Serping1 serpin family G member 1 ISO
ISS
(PMID:10946292)
GO_REF:0000024
RGD
UniProt
PMID:10946292 GO_REF:0000024 NCBI chr 3:72,161,230...72,171,109
Ensembl chr 3:72,161,189...72,171,078
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    immune system process 2844
      immune effector process 885
        complement activation 173
          complement activation, lectin pathway 14
            negative regulation of complement activation, lectin pathway + 2
            positive regulation of complement activation, lectin pathway + 0
            regulation of complement activation, lectin pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        positive regulation of biological process 6652
          positive regulation of immune system process 1015
            positive regulation of immune response 655
              activation of immune response 418
                complement activation 173
                  complement activation, lectin pathway 14
                    negative regulation of complement activation, lectin pathway + 2
                    positive regulation of complement activation, lectin pathway + 0
                    regulation of complement activation, lectin pathway + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.