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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of leukocyte mediated cytotoxicity
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Accession:GO:0001910 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
Synonyms:exact_synonym: regulation of immune cell mediated cell death;   regulation of immune cell mediated cell killing;   regulation of immune cell mediated cytotoxicity;   regulation of leucocyte mediated cytotoxicity


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negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
negative regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
G Clec12b C-type lectin domain family 12, member B JBrowse link 4 163,140,883 163,157,996 RGD:1624291
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:11568650
G Gfer growth factor, augmenter of liver regeneration JBrowse link 10 14,059,347 14,061,703 RGD:9685777
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:9685777
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Mill1 MHC I like leukocyte 1 JBrowse link 1 79,631,266 79,657,943 RGD:1624291
G RT1-A1 RT1 class Ia, locus A1 JBrowse link 20 5,414,463 5,418,012 RGD:2313500
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Sh2d1b2 SH2 domain containing 1B2 JBrowse link 13 88,557,361 88,584,078 RGD:1624291
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Klre1 killer cell lectin-like receptor, family E, member 1 JBrowse link 4 163,346,684 163,355,050 RGD:1299590
negative regulation of T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Il7r interleukin 7 receptor RGD:1624291
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1624291
RGD:1600115
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
RGD:1600115
negative regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Muc4 mucin 4, cell surface associated JBrowse link 11 71,242,973 71,285,217 RGD:2303754
positive regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
positive regulation of leukocyte mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:8549560
positive regulation of microglial cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:1624291
G Stap1 signal transducing adaptor family member 1 JBrowse link 14 23,575,400 23,604,984 RGD:1624291
G Tyrobp transmembrane immune signaling adaptor Tyrobp JBrowse link 1 88,875,370 88,879,305 RGD:1624291
RGD:13792537
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 19 41,805,252 41,860,076 RGD:1624291
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1624291
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:1624291
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 JBrowse link 19 41,805,252 41,860,076 RGD:1624291
G Cadm1 cell adhesion molecule 1 JBrowse link 8 51,858,906 52,200,591 RGD:1624291
RGD:1600115
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1624291
G Cd226 CD226 molecule JBrowse link 18 86,299,392 86,394,772 RGD:1624291
G Crtam cytotoxic and regulatory T cell molecule JBrowse link 8 45,152,584 45,216,082 RGD:1624291
G Gimap5 GTPase, IMAP family member 5 JBrowse link 4 78,377,228 78,386,683 RGD:2303778
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
G Il18rap interleukin 18 receptor accessory protein JBrowse link 9 47,225,543 47,255,805 RGD:1624291
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:1624291
G Klrb1c killer cell lectin like receptor B1C JBrowse link 4 162,528,614 162,553,421 RGD:1624291
G Klre1 killer cell lectin-like receptor, family E, member 1 JBrowse link 4 163,346,684 163,355,050 RGD:1600115
RGD:1624291
G Klrk1 killer cell lectin like receptor K1 JBrowse link 4 163,392,652 163,403,735 RGD:1600115
RGD:13792537
RGD:1624291
G Lag3 lymphocyte activating 3 JBrowse link 4 157,425,644 157,433,700 RGD:1624291
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:1624291
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like JBrowse link 20 3,242,236 3,253,995 RGD:1624291
G Ly49s3 Ly-49 stimulatory receptor 3 RGD:633264
G Ncr3 natural cytotoxicity triggering receptor 3 JBrowse link 20 5,170,169 5,175,773 RGD:1624291
RGD:13792537
RGD:1600115
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
G Raet1e retinoic acid early transcript 1E JBrowse link 1 1,101,666 1,120,340 RGD:1624291
G Raet1l retinoic acid early transcript 1L JBrowse link 7 114,233,896 114,234,243 RGD:9685184
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:1624291
G Rrlt similar to retinoic acid early transcript 1L JBrowse link 1 1,437,716 1,442,089 RGD:9685184
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 JBrowse link 20 1,814,661 1,833,033 RGD:1600115
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Sh2d1a SH2 domain containing 1A JBrowse link X 128,897,053 128,925,408 RGD:1624291
G Sh2d1b2 SH2 domain containing 1B2 JBrowse link 13 88,557,361 88,584,078 RGD:1624291
G Slamf6 SLAM family member 6 JBrowse link 13 90,300,160 90,321,781 RGD:1624291
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1624291
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:1624291
RGD:1600115
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link 9 9,617,551 9,675,167 RGD:1624291
RGD:1600115
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07032888.1 RGD:13792537
G Cd226 CD226 molecule JBrowse link 18 86,299,392 86,394,772 RGD:1624291
RGD:13792537
G Crtam cytotoxic and regulatory T cell molecule JBrowse link 8 45,152,584 45,216,082 RGD:1624291
RGD:13792537
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
RGD:1600115
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
G Klrk1 killer cell lectin like receptor K1 JBrowse link 4 163,392,652 163,403,735 RGD:9685180
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
RGD:13792537
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
RGD:13792537
G Rrlt similar to retinoic acid early transcript 1L JBrowse link 1 1,437,716 1,442,089 RGD:9685180
positive regulation of neutrophil mediated killing of fungus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg1 arginase 1 JBrowse link 1 21,525,421 21,537,872 RGD:1624291
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:1600115
RGD:1624291
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:1624291
positive regulation of neutrophil mediated killing of gram-negative bacterium term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
positive regulation of T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07044397.1 RGD:13792537
G AABR07044404.1 RGD:13792537
G Azgp1 alpha-2-glycoprotein 1, zinc-binding JBrowse link 12 19,196,565 19,203,094 RGD:13792537
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:1624291
G Cd1d1 CD1d1 molecule JBrowse link 2 186,330,298 186,333,805 RGD:1624291
RGD:13792537
G Cyrib CYFIP related Rac1 interactor B JBrowse link 7 104,514,566 104,641,875 RGD:1624291
RGD:1600115
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
RGD:1600115
G Fcgrt Fc fragment of IgG receptor and transporter JBrowse link 1 101,086,872 101,096,159 RGD:13792537
G Hfe homeostatic iron regulator JBrowse link 17 43,661,276 43,669,327 RGD:13792537
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1298959
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:10059395
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
RGD:1600115
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:1624291
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like JBrowse link 20 3,242,236 3,253,995 RGD:1624291
G Micb MHC class I polypeptide-related sequence B JBrowse link 1 79,754,587 79,772,092 RGD:13792537
G Mill1 MHC I like leukocyte 1 JBrowse link 1 79,631,266 79,657,943 RGD:13792537
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G RT1-A1 RT1 class Ia, locus A1 JBrowse link 20 5,414,463 5,418,012 RGD:2313503
RGD:13792537
G RT1-A2 RT1 class Ia, locus A2 JBrowse link 20 5,374,990 5,378,536 RGD:1624291
RGD:13792537
G RT1-CE10 RT1 class I, locus CE10 JBrowse link 20 129,192 157,689 RGD:13792537
G RT1-CE3 RT1 class I, locus CE3 JBrowse link 20 4,918,047 4,943,603 RGD:13792537
G RT1-CE4 RT1 class I, locus CE4 JBrowse link 20 4,918,523 4,921,339 RGD:13792537
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
RGD:13792537
G RT1-EC2 RT1 class Ib, locus EC2 RGD:13792537
G RT1-M2 RT1 class Ib, locus M2 JBrowse link 20 1,337,242 1,339,488 RGD:13792537
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 JBrowse link 20 1,814,661 1,833,033 RGD:13792537
G RT1-M4 RT1 class Ib, locus M4 JBrowse link 20 2,043,710 2,048,575 RGD:13792537
G RT1-M5 RT1 class Ib, locus M5 JBrowse link 20 2,038,158 2,040,422 RGD:13792537
G RT1-M6-2 RT1 class I, locus M6, gene 2 JBrowse link 20 2,075,796 2,079,183 RGD:13792537
G RT1-N2 RT1 class Ib, locus N2 JBrowse link 20 3,146,579 3,150,852 RGD:13792537
G RT1-N3 RT1 class Ib, locus N3 JBrowse link 20 3,166,793 3,170,945 RGD:13792537
G RT1-S2 RT1 class Ib, locus S2 JBrowse link 20 3,152,073 3,165,871 RGD:13792537
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
RGD:13792537
G RT1-T24-1 RT1 class I, locus T24, gene 1 JBrowse link 20 3,269,315 3,282,523 RGD:13792537
G RT1-T24-3 RT1 class I, locus T24, gene 3 JBrowse link 20 3,226,010 3,257,254 RGD:13792537
G RT1-T24-4 RT1 class I, locus T24, gene 4 JBrowse link 20 3,189,457 3,197,457 RGD:13792537
G Stx7 syntaxin 7 JBrowse link 1 22,241,655 22,281,850 RGD:1624291
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:1299069
RGD:1624291
G Xcl1 X-C motif chemokine ligand 1 JBrowse link 13 83,199,402 83,202,845 RGD:1624291
positive regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mr1 major histocompatibility complex, class I-related JBrowse link 13 72,771,992 72,789,861 RGD:1624291
G Slc22a13 solute carrier family 22 member 13 JBrowse link 8 127,885,268 127,900,829 RGD:1624291
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec2d C-type lectin domain family 2, member D JBrowse link 4 162,278,252 162,302,881 RGD:1624291
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
G Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A JBrowse link 13 27,153,500 27,159,319 RGD:1624291
G Serpinb9 serpin family B member 9 JBrowse link 17 32,648,846 32,673,047 RGD:1624291
G Tap1 transporter 1, ATP binding cassette subfamily B member JBrowse link 20 3,979,302 3,989,669 RGD:2312378
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:2312378
regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:2293335
regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1624291
RGD:1600115
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 JBrowse link 10 55,085,269 55,135,069 RGD:1624291
regulation of neutrophil mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnase1 deoxyribonuclease 1 JBrowse link 10 11,757,681 11,760,672 RGD:1624291
RGD:13464261
G Dnase1l3 deoxyribonuclease 1-like 3 JBrowse link 15 18,710,492 18,736,476 RGD:1624291
RGD:13464261
regulation of neutrophil mediated killing of gram-negative bacterium term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cxcl6 C-X-C motif chemokine ligand 6 JBrowse link 14 18,860,201 18,920,839 RGD:1624291
regulation of T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:1624291
RGD:1600115
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadm1 cell adhesion molecule 1 JBrowse link 8 51,858,906 52,200,591 RGD:1624291
RGD:13792537
RGD:1600115
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
RGD:13792537
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
RGD:13792537
G Ulbp1 UL16 binding protein 1 JBrowse link 1 1,181,301 1,200,526 RGD:1624291
susceptibility to T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
RGD:13792537
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    cellular process 18362
      regulation of cellular process 12334
        regulation of cell killing 131
          regulation of leukocyte mediated cytotoxicity 104
            negative regulation of leukocyte mediated cytotoxicity + 24
            positive regulation of leukocyte mediated cytotoxicity + 81
            regulation of T cell mediated cytotoxicity + 52
            regulation of antibody-dependent cellular cytotoxicity + 2
            regulation of microglial cell mediated cytotoxicity + 3
            regulation of natural killer cell mediated cytotoxicity + 53
            regulation of neutrophil mediated cytotoxicity + 7
Path 2
Term Annotations click to browse term
  biological_process 19578
    biological regulation 13539
      regulation of biological process 12843
        regulation of immune system process 1474
          regulation of immune effector process 443
            regulation of leukocyte mediated immunity 267
              regulation of leukocyte mediated cytotoxicity 104
                negative regulation of leukocyte mediated cytotoxicity + 24
                positive regulation of leukocyte mediated cytotoxicity + 81
                regulation of T cell mediated cytotoxicity + 52
                regulation of antibody-dependent cellular cytotoxicity + 2
                regulation of microglial cell mediated cytotoxicity + 3
                regulation of natural killer cell mediated cytotoxicity + 53
                regulation of neutrophil mediated cytotoxicity + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.