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ONTOLOGY REPORT - ANNOTATIONS


Term:T cell mediated cytotoxicity
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Accession:GO:0001913 term browser browse the term
Definition:The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
Synonyms:exact_synonym: T cell mediated apoptosis;   T cell mediated cell death;   T cell mediated cell killing;   T-lymphocyte mediated cytotoxicity
 related_synonym: T cell mediated cytolysis


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T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadm1 cell adhesion molecule 1 JBrowse link 8 51,858,906 52,200,591 RGD:1624291
G Crtam cytotoxic and regulatory T cell molecule JBrowse link 8 45,152,584 45,216,082 RGD:1624291
G Ctsc cathepsin C JBrowse link 1 151,918,514 151,949,979 RGD:1624291
G Ctsh cathepsin H JBrowse link 8 97,439,155 97,458,293 RGD:1624291
RGD:1600115
G Emp2 epithelial membrane protein 2 JBrowse link 10 5,433,248 5,467,840 RGD:1624291
RGD:1600115
G Gfus GDP-L-fucose synthase JBrowse link 7 116,958,427 116,963,281 RGD:1624291
G Gzmb granzyme B JBrowse link 15 35,413,862 35,417,293 RGD:1624291
G Gzmm granzyme M JBrowse link 7 12,893,431 12,899,004 RGD:1624291
RGD:1600115
G Hprt1 hypoxanthine phosphoribosyltransferase 1 JBrowse link X 158,196,640 158,228,815 RGD:1624291
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291
G Mill1 MHC I like leukocyte 1 JBrowse link 1 79,631,266 79,657,943 RGD:1624291
G Prf1 perforin 1 JBrowse link 20 30,915,294 30,920,804 RGD:1624291
RGD:1600115
G Raet1e retinoic acid early transcript 1E JBrowse link 1 1,101,666 1,120,340 RGD:1624291
G Serpinb9 serpin family B member 9 JBrowse link 17 32,648,846 32,673,047 RGD:1624291
G Spag6l sperm associated antigen 6-like JBrowse link 11 88,424,493 88,517,910 RGD:1600115
G Stx11 syntaxin 11 JBrowse link 1 7,039,160 7,064,870 RGD:1624291
cytotoxic T cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:1624291
G Stx11 syntaxin 11 JBrowse link 1 7,039,160 7,064,870 RGD:1624291
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
negative regulation of T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Il7r interleukin 7 receptor RGD:1624291
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1624291
RGD:1600115
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
RGD:1600115
negative regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Muc4 mucin 4, cell surface associated JBrowse link 11 71,242,973 71,285,217 RGD:2303754
positive regulation of T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07044397.1 RGD:13792537
G AABR07044404.1 RGD:13792537
G Azgp1 alpha-2-glycoprotein 1, zinc-binding JBrowse link 12 19,196,565 19,203,094 RGD:13792537
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:1624291
G Cd1d1 CD1d1 molecule JBrowse link 2 186,330,298 186,333,805 RGD:1624291
RGD:13792537
G Cyrib CYFIP related Rac1 interactor B JBrowse link 7 104,514,566 104,641,875 RGD:1624291
RGD:1600115
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
RGD:1600115
G Fcgrt Fc fragment of IgG receptor and transporter JBrowse link 1 101,086,872 101,096,159 RGD:13792537
G Hfe homeostatic iron regulator JBrowse link 17 43,661,276 43,669,327 RGD:13792537
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1298959
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:10059395
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:1624291
RGD:1600115
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:1624291
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:1624291
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like JBrowse link 20 3,242,236 3,253,995 RGD:1624291
G Micb MHC class I polypeptide-related sequence B JBrowse link 1 79,754,587 79,772,092 RGD:13792537
G Mill1 MHC I like leukocyte 1 JBrowse link 1 79,631,266 79,657,943 RGD:13792537
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G RT1-A1 RT1 class Ia, locus A1 JBrowse link 20 5,414,463 5,418,012 RGD:2313503
RGD:13792537
G RT1-A2 RT1 class Ia, locus A2 JBrowse link 20 5,374,990 5,378,536 RGD:1624291
RGD:13792537
G RT1-CE10 RT1 class I, locus CE10 JBrowse link 20 129,192 157,689 RGD:13792537
G RT1-CE3 RT1 class I, locus CE3 JBrowse link 20 4,918,047 4,943,603 RGD:13792537
G RT1-CE4 RT1 class I, locus CE4 JBrowse link 20 4,918,523 4,921,339 RGD:13792537
G RT1-CE5 RT1 class I, locus CE5 JBrowse link 20 4,892,702 4,896,993 RGD:1624291
RGD:13792537
G RT1-EC2 RT1 class Ib, locus EC2 RGD:13792537
G RT1-M2 RT1 class Ib, locus M2 JBrowse link 20 1,337,242 1,339,488 RGD:13792537
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 JBrowse link 20 1,814,661 1,833,033 RGD:13792537
G RT1-M4 RT1 class Ib, locus M4 JBrowse link 20 2,043,710 2,048,575 RGD:13792537
G RT1-M5 RT1 class Ib, locus M5 JBrowse link 20 2,038,158 2,040,422 RGD:13792537
G RT1-M6-2 RT1 class I, locus M6, gene 2 JBrowse link 20 2,075,796 2,079,183 RGD:13792537
G RT1-N2 RT1 class Ib, locus N2 JBrowse link 20 3,146,579 3,150,852 RGD:13792537
G RT1-N3 RT1 class Ib, locus N3 JBrowse link 20 3,166,793 3,170,945 RGD:13792537
G RT1-S2 RT1 class Ib, locus S2 JBrowse link 20 3,152,073 3,165,871 RGD:13792537
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:1624291
RGD:13792537
G RT1-T24-1 RT1 class I, locus T24, gene 1 JBrowse link 20 3,269,315 3,282,523 RGD:13792537
G RT1-T24-3 RT1 class I, locus T24, gene 3 JBrowse link 20 3,226,010 3,257,254 RGD:13792537
G RT1-T24-4 RT1 class I, locus T24, gene 4 JBrowse link 20 3,189,457 3,197,457 RGD:13792537
G Stx7 syntaxin 7 JBrowse link 1 22,241,655 22,281,850 RGD:1624291
G Tap2 transporter 2, ATP binding cassette subfamily B member JBrowse link 20 3,995,544 4,009,587 RGD:1299069
RGD:1624291
G Xcl1 X-C motif chemokine ligand 1 JBrowse link 13 83,199,402 83,202,845 RGD:1624291
positive regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mr1 major histocompatibility complex, class I-related JBrowse link 13 72,771,992 72,789,861 RGD:1624291
G Slc22a13 solute carrier family 22 member 13 JBrowse link 8 127,885,268 127,900,829 RGD:1624291
regulation of T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:1624291
RGD:1600115
susceptibility to T cell mediated cytotoxicity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:1624291
RGD:13792537
G Pvr PVR cell adhesion molecule JBrowse link 1 80,820,306 80,835,712 RGD:1624291
RGD:13792537
T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    cellular process 18361
      cell killing 226
        leukocyte mediated cytotoxicity 135
          T cell mediated cytotoxicity 67
            T cell mediated cytotoxicity directed against tumor cell target + 4
            cytotoxic T cell degranulation + 3
            negative regulation of T cell mediated cytotoxicity + 5
            positive regulation of T cell mediated cytotoxicity + 46
            regulation of T cell mediated cytotoxicity + 52
Path 2
Term Annotations click to browse term
  biological_process 19576
    immune system process 2692
      immune effector process 860
        leukocyte mediated immunity 501
          lymphocyte mediated immunity 397
            T cell mediated immunity 136
              T cell mediated cytotoxicity 67
                T cell mediated cytotoxicity directed against tumor cell target + 4
                cytotoxic T cell degranulation + 3
                negative regulation of T cell mediated cytotoxicity + 5
                positive regulation of T cell mediated cytotoxicity + 46
                regulation of T cell mediated cytotoxicity + 52
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.