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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cytokine-mediated signaling pathway
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Accession:GO:0001959 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.
Synonyms:exact_synonym: regulation of cytokine and chemokine mediated signaling pathway;   regulation of cytokine mediated signalling pathway


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regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd24 CD24 molecule JBrowse link 20 48,335,540 48,340,847 RGD:1624291
RGD:8553244
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:1624291
negative regulation of chemokine-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:1600115
G Padi2 peptidyl arginine deiminase 2 JBrowse link 5 159,428,479 159,471,113 RGD:1600115
RGD:1624291
G Rnf113a1 ring finger protein 113A1 JBrowse link X 123,806,922 123,808,049 RGD:1624291
G Robo1 roundabout guidance receptor 1 JBrowse link 11 9,079,291 10,146,302 RGD:1624291
RGD:1600115
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
RGD:1600115
G Slit2 slit guidance ligand 2 JBrowse link 14 66,831,848 67,171,491 RGD:1624291
RGD:1600115
G Slit3 slit guidance ligand 3 JBrowse link 10 19,924,200 20,517,918 RGD:1624291
RGD:1600115
negative regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Ecm1 extracellular matrix protein 1 JBrowse link 2 197,855,468 197,860,973 RGD:1624291
G Il36rn interleukin 36 receptor antagonist JBrowse link 3 1,385,256 1,392,275 RGD:1624291
G Palm3 paralemmin 3 JBrowse link 19 25,143,464 25,152,275 RGD:1624291
RGD:13792537
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
RGD:1600115
G Ptprf protein tyrosine phosphatase, receptor type, F JBrowse link 5 137,036,936 137,112,930 RGD:1642742
G Sigirr single Ig and TIR domain containing JBrowse link 1 213,898,395 213,907,697 RGD:1624291
RGD:1600115
negative regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg1 arginase 1 JBrowse link 1 21,525,421 21,537,872 RGD:1624291
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
G Otop1 otopetrin 1 JBrowse link 14 77,236,278 77,263,729 RGD:1600115
RGD:1624291
G Parp14 poly (ADP-ribose) polymerase family, member 14 JBrowse link 11 68,105,442 68,137,509 RGD:1624291
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:1624291
RGD:1600115
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:1600115
RGD:13792537
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
G Otud4 OTU deubiquitinase 4 JBrowse link 19 31,895,753 31,942,509 RGD:1624291
RGD:13792537
negative regulation of interleukin-2-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of Kit signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rabgef1 RAB guanine nucleotide exchange factor 1 JBrowse link 12 29,960,132 30,004,727 RGD:1624291
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
RGD:1600115
negative regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Stap1 signal transducing adaptor family member 1 JBrowse link 14 23,575,400 23,604,984 RGD:1624291
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1624291
RGD:1600115
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
G Ccdc3 coiled-coil domain containing 3 JBrowse link 17 76,991,722 77,093,515 RGD:1624291
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Gps2 G protein pathway suppressor 2 JBrowse link 10 56,524,327 56,527,447 RGD:1624291
G Hist2h2be histone cluster 2 H2B family member E JBrowse link 2 198,360,837 198,363,399 RGD:1624291
G Nlrp1b NLR family, pyrin domain containing 1B JBrowse link 10 57,755,957 57,847,867 RGD:1624291
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:1600115
RGD:1624291
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:1600115
RGD:1624291
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:1624291
G Pias4 protein inhibitor of activated STAT, 4 JBrowse link 7 11,414,565 11,428,090 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase JBrowse link 10 70,157,621 70,220,618 RGD:1624291
RGD:1600115
G Traip TRAF-interacting protein JBrowse link 8 116,730,170 116,750,528 RGD:1624291
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adar adenosine deaminase, RNA-specific JBrowse link 2 189,045,551 189,085,448 RGD:1624291
RGD:1600115
G Cactin cactin, spliceosome C complex subunit JBrowse link 7 11,258,526 11,266,509 RGD:1624291
G Cnot7 CCR4-NOT transcription complex, subunit 7 JBrowse link 16 54,899,452 54,918,616 RGD:1624291
G Dcst1 DC-STAMP domain containing 1 JBrowse link 2 188,672,549 188,690,004 RGD:1624291
G Mettl3 methyltransferase-like 3 JBrowse link 15 28,710,299 28,721,491 RGD:1624291
G Mmp12 matrix metallopeptidase 12 JBrowse link 8 5,594,717 5,616,494 RGD:1600115
RGD:1624291
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
G Nlrc5 NLR family, CARD domain containing 5 JBrowse link 19 10,904,381 11,006,202 RGD:1624291
RGD:13792537
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 JBrowse link 3 153,210,829 153,250,705 RGD:1624291
G Trex1 three prime repair exonuclease 1 JBrowse link 8 117,796,127 117,797,427 RGD:1624291
G Ttll12 tubulin tyrosine ligase like 12 JBrowse link 7 124,472,758 124,491,004 RGD:1624291
G Ythdf2 YTH N(6)-methyladenosine RNA binding protein 2 JBrowse link 5 150,364,490 150,390,173 RGD:1624291
G Ythdf3 YTH N(6)-methyladenosine RNA binding protein 3 JBrowse link 2 100,677,388 100,711,365 RGD:1624291
positive regulation of C-C chemokine receptor CCR7 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
positive regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:1624291
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
RGD:13792537
RGD:1600115
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Il7 interleukin 7 JBrowse link 2 96,427,884 96,474,979 RGD:1600115
RGD:1624291
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 JBrowse link 10 61,456,144 61,577,412 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Trim44 tripartite motif-containing 44 JBrowse link 3 91,968,781 92,242,138 RGD:1600115
RGD:1624291
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:1624291
positive regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hpx hemopexin JBrowse link 1 170,423,558 170,431,066 RGD:1624291
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G Med1 mediator complex subunit 1 JBrowse link 10 86,101,560 86,145,271 RGD:1624291
G Nlrc5 NLR family, CARD domain containing 5 JBrowse link 19 10,904,381 11,006,202 RGD:1624291
G Parp9 poly (ADP-ribose) polymerase family, member 9 JBrowse link 11 67,724,071 67,758,027 RGD:1624291
RGD:13792537
G Txk TXK tyrosine kinase JBrowse link 14 38,029,809 38,085,822 RGD:1624291
positive regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:1624291
RGD:1600115
positive regulation of interleukin-17-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trim32 tripartite motif-containing 32 JBrowse link 5 81,431,554 81,449,023 RGD:1624291
positive regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:1624291
positive regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd300lf Cd300 molecule-like family member F JBrowse link 10 103,669,781 103,690,584 RGD:1624291
RGD:1600115
G Parp14 poly (ADP-ribose) polymerase family, member 14 JBrowse link 11 68,105,442 68,137,509 RGD:1624291
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qtnf4 C1q and TNF related 4 JBrowse link 3 79,713,580 79,718,018 RGD:1624291
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link 14 3,058,035 3,073,332 RGD:1624291
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:1624291
positive regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Csf1 colony stimulating factor 1 JBrowse link 2 210,522,370 210,550,546 RGD:1624291
RGD:1600115
positive regulation of macrophage migration inhibitory factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:1624291
positive regulation of prolactin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crebrf CREB3 regulatory factor JBrowse link 10 16,693,846 16,753,162 RGD:1624291
positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:1624291
RGD:1600115
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:1624291
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:1624291
G Cpne1 copine 1 JBrowse link 3
3
151,617,733
152,150,143
151,625,448
152,192,936
RGD:1624291
RGD:13792537
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1624291
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
RGD:1600115
G Rbm12 RNA binding motif protein 12 JBrowse link 3 151,616,038 151,658,427 RGD:13792537
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:1624291
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:1624291
G Trim32 tripartite motif-containing 32 JBrowse link 5 81,431,554 81,449,023 RGD:1624291
G Ube2k ubiquitin-conjugating enzyme E2K JBrowse link 14 44,289,247 44,348,691 RGD:1624291
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon JBrowse link 13 48,031,325 48,056,394 RGD:1624291
G Irf3 interferon regulatory factor 3 JBrowse link 1 100,992,244 100,997,202 RGD:1624291
G Irf7 interferon regulatory factor 7 JBrowse link 1 214,249,388 214,252,909 RGD:1624291
G Lsm14a LSM14A mRNA processing body assembly factor JBrowse link 1 90,200,866 90,246,292 RGD:1624291
G Mavs mitochondrial antiviral signaling protein JBrowse link 3 123,776,147 123,790,572 RGD:1624291
G Mmp12 matrix metallopeptidase 12 JBrowse link 8 5,594,717 5,616,494 RGD:1600115
RGD:1624291
G Nlrc5 NLR family, CARD domain containing 5 JBrowse link 19 10,904,381 11,006,202 RGD:1624291
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:1624291
G Trim6 tripartite motif containing 6 JBrowse link 1 169,410,084 169,423,305 RGD:1624291
G Ube2k ubiquitin-conjugating enzyme E2K JBrowse link 14 44,289,247 44,348,691 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
G Zbp1 Z-DNA binding protein 1 JBrowse link 3 171,276,062 171,292,062 RGD:1624291
RGD:1600115
RGD:13792537
regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc37 cell division cycle 37, HSP90 cochaperone JBrowse link 8 22,160,922 22,173,797 RGD:1624291
RGD:1600115
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1624291
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:1600115
regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vrk2 VRK serine/threonine kinase 2 JBrowse link 14 110,739,835 110,883,836 RGD:1624291
G Zbp1 Z-DNA binding protein 1 JBrowse link 3 171,276,062 171,292,062 RGD:1600115
RGD:1624291
regulation of macrophage migration inhibitory factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:1624291
RGD:1600115
regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1600115
RGD:1624291
G Hipk1 homeodomain interacting protein kinase 1 JBrowse link 2 206,224,015 206,274,910 RGD:1624291
RGD:1600115
G Otulin OTU deubiquitinase with linear linkage specificity JBrowse link 2 80,267,724 80,293,204 RGD:1624291
RGD:13792537
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:1624291
RGD:1600115
G Spata2 spermatogenesis associated 2 JBrowse link 3 164,229,211 164,239,483 RGD:1600115
RGD:13792537
RGD:1624291
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:1624291
RGD:1600115
RGD:14397556
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1624291
RGD:1600115
regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc37 cell division cycle 37, HSP90 cochaperone JBrowse link 8 22,160,922 22,173,797 RGD:1624291
RGD:1600115
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    cellular process 18452
      signal transduction 6946
        regulation of signal transduction 2971
          regulation of cytokine-mediated signaling pathway 113
            negative regulation of cytokine-mediated signaling pathway + 54
            positive regulation of cytokine-mediated signaling pathway + 47
            regulation of Kit signaling pathway + 2
            regulation of chemokine-mediated signaling pathway + 8
            regulation of interferon-gamma-mediated signaling pathway + 15
            regulation of interleukin-1-mediated signaling pathway + 7
            regulation of interleukin-17-mediated signaling pathway + 1
            regulation of interleukin-18-mediated signaling pathway + 1
            regulation of interleukin-2-mediated signaling pathway + 1
            regulation of interleukin-27-mediated signaling pathway + 0
            regulation of interleukin-35-mediated signaling pathway + 0
            regulation of interleukin-4-mediated signaling pathway + 3
            regulation of interleukin-6-mediated signaling pathway + 5
            regulation of macrophage colony-stimulating factor signaling pathway + 3
            regulation of macrophage migration inhibitory factor signaling pathway + 3
            regulation of prolactin signaling pathway + 1
            regulation of tumor necrosis factor-mediated signaling pathway + 35
            regulation of type I interferon-mediated signaling pathway + 27
Path 2
Term Annotations click to browse term
  biological_process 19678
    cellular process 18452
      cellular response to stimulus 8832
        cellular response to chemical stimulus 3491
          cellular response to organic substance 2822
            cellular response to cytokine stimulus 993
              cytokine-mediated signaling pathway 402
                regulation of cytokine-mediated signaling pathway 113
                  negative regulation of cytokine-mediated signaling pathway + 54
                  positive regulation of cytokine-mediated signaling pathway + 47
                  regulation of Kit signaling pathway + 2
                  regulation of chemokine-mediated signaling pathway + 8
                  regulation of interferon-gamma-mediated signaling pathway + 15
                  regulation of interleukin-1-mediated signaling pathway + 7
                  regulation of interleukin-17-mediated signaling pathway + 1
                  regulation of interleukin-18-mediated signaling pathway + 1
                  regulation of interleukin-2-mediated signaling pathway + 1
                  regulation of interleukin-27-mediated signaling pathway + 0
                  regulation of interleukin-35-mediated signaling pathway + 0
                  regulation of interleukin-4-mediated signaling pathway + 3
                  regulation of interleukin-6-mediated signaling pathway + 5
                  regulation of macrophage colony-stimulating factor signaling pathway + 3
                  regulation of macrophage migration inhibitory factor signaling pathway + 3
                  regulation of prolactin signaling pathway + 1
                  regulation of tumor necrosis factor-mediated signaling pathway + 35
                  regulation of type I interferon-mediated signaling pathway + 27
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.