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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cytokine-mediated signaling pathway
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Accession:GO:0001960 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
Synonyms:exact_synonym: down-regulation of cytokine mediated signaling pathway;   downregulation of cytokine mediated signaling pathway;   negative regulation of cytokine and chemokine mediated signaling pathway;   negative regulation of cytokine mediated signalling pathway
 narrow_synonym: inhibition of cytokine mediated signaling pathway


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negative regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1624291
RGD:1600115
G Ecm1 extracellular matrix protein 1 JBrowse link 2 197,855,468 197,860,973 RGD:1624291
G Il36rn interleukin 36 receptor antagonist JBrowse link 3 1,385,256 1,392,275 RGD:1624291
G Palm3 paralemmin 3 JBrowse link 19 25,143,464 25,152,275 RGD:1624291
RGD:13792537
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
RGD:1600115
G Ptprf protein tyrosine phosphatase, receptor type, F JBrowse link 5 137,036,936 137,112,930 RGD:1642742
G Sigirr single Ig and TIR domain containing JBrowse link 1 213,898,395 213,907,697 RGD:1624291
RGD:1600115
negative regulation of chemokine-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:1600115
G Padi2 peptidyl arginine deiminase 2 JBrowse link 5 159,428,479 159,471,113 RGD:1600115
RGD:1624291
G Rnf113a1 ring finger protein 113A1 JBrowse link X 123,806,922 123,808,049 RGD:1624291
G Robo1 roundabout guidance receptor 1 JBrowse link 11 9,079,291 10,146,302 RGD:1624291
RGD:1600115
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
RGD:1600115
G Slit2 slit guidance ligand 2 JBrowse link 14 66,831,848 67,171,491 RGD:1624291
RGD:1600115
G Slit3 slit guidance ligand 3 JBrowse link 10 19,924,200 20,517,918 RGD:1624291
RGD:1600115
negative regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg1 arginase 1 JBrowse link 1 21,525,421 21,537,872 RGD:1624291
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
G Otop1 otopetrin 1 JBrowse link 14 77,236,278 77,263,729 RGD:1600115
RGD:1624291
G Parp14 poly (ADP-ribose) polymerase family, member 14 JBrowse link 11 68,105,442 68,137,509 RGD:1624291
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:1624291
RGD:1600115
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:1600115
RGD:13792537
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
G Otud4 OTU deubiquitinase 4 JBrowse link 19 31,895,753 31,942,509 RGD:1624291
RGD:13792537
negative regulation of interleukin-2-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of Kit signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rabgef1 RAB guanine nucleotide exchange factor 1 JBrowse link 12 29,960,132 30,004,727 RGD:1624291
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:1624291
RGD:1600115
negative regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Stap1 signal transducing adaptor family member 1 JBrowse link 14 23,575,400 23,604,984 RGD:1624291
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1624291
RGD:1600115
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
G Ccdc3 coiled-coil domain containing 3 JBrowse link 17 76,991,722 77,093,515 RGD:1624291
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:1624291
RGD:1600115
G Gps2 G protein pathway suppressor 2 JBrowse link 10 56,524,327 56,527,447 RGD:1624291
G Hist2h2be histone cluster 2 H2B family member E JBrowse link 2 198,360,837 198,363,399 RGD:1624291
G Nlrp1b NLR family, pyrin domain containing 1B JBrowse link 10 57,755,957 57,847,867 RGD:1624291
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:1600115
RGD:1624291
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:1600115
RGD:1624291
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:1624291
G Pias4 protein inhibitor of activated STAT, 4 JBrowse link 7 11,414,565 11,428,090 RGD:1624291
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase JBrowse link 10 70,157,621 70,220,618 RGD:1624291
RGD:1600115
G Traip TRAF-interacting protein JBrowse link 8 116,730,170 116,750,528 RGD:1624291
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adar adenosine deaminase, RNA-specific JBrowse link 2 189,045,551 189,085,448 RGD:1624291
RGD:1600115
G Cactin cactin, spliceosome C complex subunit JBrowse link 7 11,258,526 11,266,509 RGD:1624291
G Cnot7 CCR4-NOT transcription complex, subunit 7 JBrowse link 16 54,899,452 54,918,616 RGD:1624291
G Dcst1 DC-STAMP domain containing 1 JBrowse link 2 188,672,549 188,690,004 RGD:1624291
G Mettl3 methyltransferase-like 3 JBrowse link 15 28,710,299 28,721,491 RGD:1624291
G Mmp12 matrix metallopeptidase 12 JBrowse link 8 5,594,717 5,616,494 RGD:1600115
RGD:1624291
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
G Nlrc5 NLR family, CARD domain containing 5 JBrowse link 19 10,904,381 11,006,202 RGD:1624291
RGD:13792537
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 JBrowse link 3 153,210,829 153,250,705 RGD:1624291
G Trex1 three prime repair exonuclease 1 JBrowse link 8 117,796,127 117,797,427 RGD:1624291
G Ttll12 tubulin tyrosine ligase like 12 JBrowse link 7 124,472,758 124,491,004 RGD:1624291
G Ythdf2 YTH N(6)-methyladenosine RNA binding protein 2 JBrowse link 5 150,364,490 150,390,173 RGD:1624291
G Ythdf3 YTH N(6)-methyladenosine RNA binding protein 3 JBrowse link 2 100,677,388 100,711,365 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18617
      signal transduction 6968
        negative regulation of signal transduction 1232
          negative regulation of cytokine-mediated signaling pathway 54
            negative regulation of Kit signaling pathway 2
            negative regulation of chemokine-mediated signaling pathway + 7
            negative regulation of interferon-gamma-mediated signaling pathway 6
            negative regulation of interleukin-1-mediated signaling pathway 4
            negative regulation of interleukin-17-mediated signaling pathway 0
            negative regulation of interleukin-18-mediated signaling pathway 0
            negative regulation of interleukin-2-mediated signaling pathway 1
            negative regulation of interleukin-27-mediated signaling pathway 0
            negative regulation of interleukin-35-mediated signaling pathway 0
            negative regulation of interleukin-4-mediated signaling pathway 1
            negative regulation of interleukin-6-mediated signaling pathway 2
            negative regulation of macrophage colony-stimulating factor signaling pathway 2
            negative regulation of macrophage migration inhibitory factor signaling pathway 0
            negative regulation of prolactin signaling pathway 0
            negative regulation of tumor necrosis factor-mediated signaling pathway 15
            negative regulation of type I interferon-mediated signaling pathway + 14
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            cell surface receptor signaling pathway 2772
              cytokine-mediated signaling pathway 404
                regulation of cytokine-mediated signaling pathway 113
                  negative regulation of cytokine-mediated signaling pathway 54
                    negative regulation of Kit signaling pathway 2
                    negative regulation of chemokine-mediated signaling pathway + 7
                    negative regulation of interferon-gamma-mediated signaling pathway 6
                    negative regulation of interleukin-1-mediated signaling pathway 4
                    negative regulation of interleukin-17-mediated signaling pathway 0
                    negative regulation of interleukin-18-mediated signaling pathway 0
                    negative regulation of interleukin-2-mediated signaling pathway 1
                    negative regulation of interleukin-27-mediated signaling pathway 0
                    negative regulation of interleukin-35-mediated signaling pathway 0
                    negative regulation of interleukin-4-mediated signaling pathway 1
                    negative regulation of interleukin-6-mediated signaling pathway 2
                    negative regulation of macrophage colony-stimulating factor signaling pathway 2
                    negative regulation of macrophage migration inhibitory factor signaling pathway 0
                    negative regulation of prolactin signaling pathway 0
                    negative regulation of tumor necrosis factor-mediated signaling pathway 15
                    negative regulation of type I interferon-mediated signaling pathway + 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.