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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of cytokine-mediated signaling pathway
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Accession:GO:0001961 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.
Synonyms:exact_synonym: positive regulation of cytokine and chemokine mediated signaling pathway;   positive regulation of cytokine mediated signalling pathway;   up-regulation of cytokine mediated signaling pathway;   upregulation of cytokine mediated signaling pathway
 narrow_synonym: activation of cytokine mediated signaling pathway;   stimulation of cytokine mediated signaling pathway


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positive regulation of cytokine-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase ISO (PMID:18840707) RGD PMID:18840707 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Cd74 CD74 molecule ISO
IBA
ISS
(MGI:MGI:4419085|PMID:12782713)
PMID:21873635
GO_REF:0000024
(PMID:12782713)
RGD
BHF-UCL
PMID:12782713, PMID:21873635 GO_REF:0000024, MGI:MGI:4419085, RGD:13792537 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Gas6 growth arrest specific 6 ISO
ISS
(PMID:18840707)
GO_REF:0000024
RGD
UniProt
PMID:18840707 GO_REF:0000024 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Il7 interleukin 7 IEA
ISO
GO_REF:0000107
(PMID:11418668)
Ensembl
RGD
PMID:11418668 GO_REF:0000107 NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO (MGI:MGI:5308511|PMID:22073305) RGD PMID:22073305 MGI:MGI:5308511 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 ISO MGI:MGI:2446070 (MGI:MGI:2176424|PMID:11894097) RGD PMID:11894097 MGI:MGI:2176424 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Trim44 tripartite motif-containing 44 IEA
ISO
GO_REF:0000107
(PMID:23460740)
Ensembl
RGD
PMID:23460740 GO_REF:0000107 NCBI chr 3:91,968,781...92,242,138
Ensembl chr 3:92,183,556...92,242,318
JBrowse link
G Tslp thymic stromal lymphopoietin ISO (PMID:11418668) RGD PMID:11418668 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
positive regulation of C-C chemokine receptor CCR7 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 ISO (PMID:11602640) RGD PMID:11602640 NCBI chr 9:14,611,541...14,618,076
Ensembl chr 9:14,611,561...14,618,013
JBrowse link
positive regulation of interferon-gamma-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpx hemopexin ISO MGI:MGI:2447193 (MGI:MGI:3807609|PMID:18641331) RGD PMID:18641331 MGI:MGI:3807609 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Irgm immunity-related GTPase M ISO (PMID:16888103)
(MGI:MGI:3656111|PMID:16888103)
RGD PMID:16888103 MGI:MGI:3656111 NCBI chr10:34,213,885...34,221,968
Ensembl chr10:34,213,936...34,221,928
JBrowse link
G Med1 mediator complex subunit 1 ISO MGI:MGI:2176946|MGI:MGI:3511276 (MGI:MGI:3798012|PMID:18339625) RGD PMID:18339625 MGI:MGI:3798012 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 ISO (PMID:20061403), (PMID:20639463) RGD PMID:20061403, PMID:20639463 NCBI chr19:10,904,381...11,006,202
Ensembl chr19:10,905,542...10,976,396
JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 ISO
IBA
(PMID:27796300)
PMID:21873635
(MGI:MGI:5905929|PMID:27796300)
RGD PMID:27796300, PMID:21873635 MGI:MGI:5905929, RGD:13792537 NCBI chr11:67,724,071...67,758,027
Ensembl chr11:67,724,076...67,756,799
JBrowse link
G Txk TXK tyrosine kinase ISO (PMID:11859127) RGD PMID:11859127 NCBI chr14:38,029,809...38,085,822
Ensembl chr14:38,030,189...38,085,919
JBrowse link
positive regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r1 interleukin 1 receptor type 1 ISO
IEA
PR:000045524 (MGI:MGI:5468848|PMID:23395675)
GO_REF:0000107
RGD
Ensembl
PMID:23395675 GO_REF:0000107, MGI:MGI:5468848 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
positive regulation of interleukin-17-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trim32 tripartite motif-containing 32 ISO (MGI:MGI:4453084|PMID:20054338) RGD PMID:20054338 MGI:MGI:4453084 NCBI chr 5:81,431,554...81,449,023
Ensembl chr 5:81,431,600...81,442,451
JBrowse link
positive regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ticam2 toll-like receptor adaptor molecule 2 ISO (PMID:22685567)
(MGI:MGI:5488868|PMID:22685567)
RGD PMID:22685567 MGI:MGI:5488868 NCBI chr18:40,555,106...40,572,569
Ensembl chr18:40,555,106...40,572,241
JBrowse link
positive regulation of interleukin-4-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300lf Cd300 molecule-like family member F ISO
ISS
(MGI:MGI:5660125|PMID:26124135)
GO_REF:0000024
RGD
UniProt
PMID:26124135 GO_REF:0000024, MGI:MGI:5660125 NCBI chr10:103,669,781...103,690,584
Ensembl chr10:103,670,028...103,687,425
JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 ISO (PMID:27796300)
(MGI:MGI:5905929|PMID:27796300)
RGD PMID:27796300 MGI:MGI:5905929 NCBI chr11:68,105,442...68,137,509
Ensembl chr11:68,105,369...68,137,535
JBrowse link
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qtnf4 C1q and TNF related 4 ISO (PMID:21658842) RGD PMID:21658842 NCBI chr 3:79,713,580...79,718,018
Ensembl chr 3:79,713,567...79,718,025
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor ISO (PMID:11060035) RGD PMID:11060035 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (PMID:31827280)
(MGI:MGI:6401044|PMID:31827281)
RGD PMID:31827280, PMID:31827281 MGI:MGI:6401044 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
positive regulation of macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf1 colony stimulating factor 1 ISO
IEA
(PMID:19100238)
GO_REF:0000107
RGD
Ensembl
PMID:19100238 GO_REF:0000107 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
positive regulation of macrophage migration inhibitory factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule ISO (PMID:19665027) RGD PMID:19665027 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO (PMID:19665027) RGD PMID:19665027 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
positive regulation of prolactin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crebrf CREB3 regulatory factor ISO (MGI:MGI:5466657|PMID:23071095) RGD PMID:23071095 MGI:MGI:5466657 NCBI chr10:16,693,846...16,753,162
Ensembl chr10:16,694,792...16,752,205
JBrowse link
positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO
IEA
(PMID:24813629)
GO_REF:0000107
RGD
Ensembl
PMID:24813629 GO_REF:0000107 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Casp1 caspase 1 ISO (PMID:16920334) RGD PMID:16920334 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp4 caspase 4 ISO (PMID:16920334) RGD PMID:16920334 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Cpne1 copine 1 ISO
IBA
(PMID:14674885)
PMID:21873635
RGD PMID:14674885, PMID:21873635 RGD:13792537 NCBI chr 3:151,617,733...151,625,448
NCBI chr 3:152,150,143...152,192,936
Ensembl chr 3:151,616,037...151,625,644
Ensembl chr 3:151,616,037...151,625,644
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO
ISS
(PMID:23453807)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:23453807 GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rbm12 RNA binding motif protein 12 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:151,616,038...151,658,427
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (MGI:MGI:6271183|PMID:30439713) RGD PMID:30439713 MGI:MGI:6271183 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO (MGI:MGI:5616328|PMID:11374864) RGD PMID:11374864 MGI:MGI:5616328 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Trim32 tripartite motif-containing 32 ISO (MGI:MGI:4453084|PMID:20054338) RGD PMID:20054338 MGI:MGI:4453084 NCBI chr 5:81,431,554...81,449,023
Ensembl chr 5:81,431,600...81,442,451
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K ISO (PMID:26707646) RGD PMID:26707646 NCBI chr14:44,289,247...44,348,691
Ensembl chr14:44,289,247...44,348,691
JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain ISO (PMID:21109225) RGD PMID:21109225 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon ISO (MGI:MGI:5792628|PMID:27129230) RGD PMID:27129230 MGI:MGI:5792628 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Irf3 interferon regulatory factor 3 ISO (MGI:MGI:3718275|PMID:17618271) RGD PMID:17618271 MGI:MGI:3718275 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf7 interferon regulatory factor 7 ISO (MGI:MGI:3718275|PMID:17618271) RGD PMID:17618271 MGI:MGI:3718275 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Lsm14a LSM14A mRNA processing body assembly factor ISO (MGI:MGI:5432265|PMID:22745163) RGD PMID:22745163 MGI:MGI:5432265 NCBI chr 1:90,200,866...90,246,292
Ensembl chr 1:90,200,876...90,246,297
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO (PMID:16127453), (PMID:20451243) RGD PMID:16127453, PMID:20451243 NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
JBrowse link
G Mmp12 matrix metallopeptidase 12 IEA
ISO
GO_REF:0000107
(MGI:MGI:5583923|PMID:24784232)
Ensembl
RGD
PMID:24784232 GO_REF:0000107, MGI:MGI:5583923 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 ISO (PMID:20061403) RGD PMID:20061403 NCBI chr19:10,904,381...11,006,202
Ensembl chr19:10,905,542...10,976,396
JBrowse link
G Tbk1 TANK-binding kinase 1 ISO (MGI:MGI:5792628|PMID:27129230) RGD PMID:27129230 MGI:MGI:5792628 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Trim6 tripartite motif containing 6 ISO (PMID:24882218)
(MGI:MGI:5645191|PMID:24882218)
RGD PMID:24882218 MGI:MGI:5645191 NCBI chr 1:169,410,084...169,423,305
Ensembl chr 1:169,410,115...169,423,283
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K ISO (PMID:24882218) RGD PMID:24882218 NCBI chr14:44,289,247...44,348,691
Ensembl chr14:44,289,247...44,348,691
JBrowse link
G Wnt5a Wnt family member 5A ISO
IEA
(PMID:19399181)
GO_REF:0000107
RGD
Ensembl
PMID:19399181 GO_REF:0000107 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Zbp1 Z-DNA binding protein 1 ISO
IEA
IBA
(MGI:MGI:3718275|PMID:17618271)
GO_REF:0000002
PMID:21873635
RGD
InterPro
PMID:17618271, PMID:21873635 GO_REF:0000002, MGI:MGI:3718275, RGD:13792537 NCBI chr 3:171,276,062...171,292,062
Ensembl chr 3:171,276,062...171,286,537
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      signal transduction 7015
        positive regulation of signal transduction 1682
          positive regulation of cytokine-mediated signaling pathway 47
            positive regulation of Kit signaling pathway 0
            positive regulation of chemokine-mediated signaling pathway + 1
            positive regulation of interferon-gamma-mediated signaling pathway 6
            positive regulation of interleukin-1-mediated signaling pathway 1
            positive regulation of interleukin-17-mediated signaling pathway 1
            positive regulation of interleukin-18-mediated signaling pathway 1
            positive regulation of interleukin-2-mediated signaling pathway 0
            positive regulation of interleukin-27-mediated signaling pathway 0
            positive regulation of interleukin-35-mediated signaling pathway 0
            positive regulation of interleukin-4-mediated signaling pathway 2
            positive regulation of interleukin-6-mediated signaling pathway 3
            positive regulation of macrophage colony-stimulating factor signaling pathway 1
            positive regulation of macrophage migration inhibitory factor signaling pathway 2
            positive regulation of prolactin signaling pathway 1
            positive regulation of tumor necrosis factor-mediated signaling pathway 12
            positive regulation of type I interferon-mediated signaling pathway 13
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            cell surface receptor signaling pathway 2782
              cytokine-mediated signaling pathway 404
                regulation of cytokine-mediated signaling pathway 113
                  positive regulation of cytokine-mediated signaling pathway 47
                    positive regulation of Kit signaling pathway 0
                    positive regulation of chemokine-mediated signaling pathway + 1
                    positive regulation of interferon-gamma-mediated signaling pathway 6
                    positive regulation of interleukin-1-mediated signaling pathway 1
                    positive regulation of interleukin-17-mediated signaling pathway 1
                    positive regulation of interleukin-18-mediated signaling pathway 1
                    positive regulation of interleukin-2-mediated signaling pathway 0
                    positive regulation of interleukin-27-mediated signaling pathway 0
                    positive regulation of interleukin-35-mediated signaling pathway 0
                    positive regulation of interleukin-4-mediated signaling pathway 2
                    positive regulation of interleukin-6-mediated signaling pathway 3
                    positive regulation of macrophage colony-stimulating factor signaling pathway 1
                    positive regulation of macrophage migration inhibitory factor signaling pathway 2
                    positive regulation of prolactin signaling pathway 1
                    positive regulation of tumor necrosis factor-mediated signaling pathway 12
                    positive regulation of type I interferon-mediated signaling pathway 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.