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ONTOLOGY REPORT - ANNOTATIONS


Term:desensitization of G protein-coupled receptor signaling pathway
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Accession:GO:0002029 term browser browse the term
Definition:The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
Synonyms:exact_synonym: desensitisation of G-protein coupled receptor protein signalling pathway;   desensitization of G-protein coupled receptor protein signaling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gipr gastric inhibitory polypeptide receptor IDA RGD PMID:8928774 RGD:2312614 NCBI chr 1:80,063,047...80,073,223
Ensembl chr 1:80,063,049...80,073,223
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IC
IMP
ISO
IEA
IDA
MGI:MGI:2180127|MGI:MGI:87937 (MGI:MGI:1337704|PMID:10338466), (MGI:MGI:84440|PMID:7761854)
GO_REF:0000107
PMID:18223549
RGD
Ensembl
PMID:7761854, PMID:10338466, PMID:1403099, PMID:30075183, PMID:18223549, PMID:17908240 GO_REF:0000107, MGI:MGI:1337704, MGI:MGI:84440, RGD:632163, RGD:13792694, RGD:8553863, RGD:7242040 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IC
IMP
IDA
RGD PMID:1403099, PMID:8381966, PMID:20837135 RGD:632163, RGD:5685621, RGD:5685022 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:15166006 RGD:1598508 NCBI chr14:81,261,708...81,339,516
Ensembl chr14:81,265,672...81,339,526
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IMP RGD PMID:8626574, PMID:30075183 RGD:61618, RGD:13792694 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IDA
IMP
RGD PMID:12810562, PMID:17908240 RGD:1299124, RGD:7242040 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
JBrowse link
G Grm5 glutamate metabotropic receptor 5 IDA PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Ly6g6e lymphocyte antigen 6 family member G6E ISO
IBA
(MGI:MGI:5694852|PMID:26276394)
PMID:21873635
RGD PMID:26276394, PMID:21873635 MGI:MGI:5694852, RGD:13792537 NCBI chr20:5,063,148...5,069,032
Ensembl chr20:5,067,330...5,068,624
JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:9350980 RGD:9850278 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 ISO
ISS
(PMID:15123695)
GO_REF:0000024
RGD
HGNC
PMID:15123695 GO_REF:0000024 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 NOT ISO (PMID:15123695) RGD PMID:15123695 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Arrb2 arrestin, beta 2 IMP
ISO
(PMID:12582207) RGD PMID:12582207, PMID:20705669 RGD:5509896 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Arr3 arrestin 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:70,438,590...70,452,140
Ensembl chr  X:70,438,617...70,452,067
JBrowse link
G Arrb1 arrestin, beta 1 ISO
IBA
(PMID:10521508), (PMID:12582207)
PMID:21873635
RGD PMID:10521508, PMID:12582207, PMID:21873635 RGD:13792537 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 ISO
IBA
(PMID:10644702), (PMID:12582207)
PMID:21873635
RGD PMID:10644702, PMID:12582207, PMID:21873635 RGD:13792537 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Calca calcitonin-related polypeptide alpha ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Dnm1 dynamin 1 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 3:11,338,081...11,382,043
Ensembl chr 3:11,338,083...11,382,043
JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524
JBrowse link
G Drd2 dopamine receptor D2 IDA RGD PMID:14617818 RGD:1581465 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 IDA
ISO
(PMID:18424554) RGD PMID:18424554, PMID:14617818 RGD:1581465 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:12519791 RGD:1304268 NCBI chr14:81,261,708...81,339,516
Ensembl chr14:81,265,672...81,339,526
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO (MGI:MGI:4821070|PMID:17325130) RGD PMID:17325130 MGI:MGI:4821070 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B IEA
ISO
GO_REF:0000107
(MGI:MGI:4821070|PMID:17325130)
Ensembl
RGD
PMID:17325130 GO_REF:0000107, MGI:MGI:4821070 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Pld2 phospholipase D2 ISO (MGI:MGI:3042801|PMID:14718562) RGD PMID:14718562 MGI:MGI:3042801 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Sag S-antigen visual arrestin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:94,926,901...94,972,162
Ensembl chr 9:94,928,489...94,972,027
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II beta ISO (MGI:MGI:4352609|PMID:19332541) RGD PMID:19332541 MGI:MGI:4352609 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 ISO (PMID:17689978) RGD PMID:17689978 NCBI chr19:52,086,325...52,112,633
Ensembl chr19:52,086,325...52,112,629
JBrowse link
G Ubqln2 ubiquilin 2 ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:18,723,313...18,726,732
Ensembl chr  X:18,723,341...18,726,732
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apln apelin IDA
ISO
PMID:11359874
(MGI:MGI:5902690|PMID:11359874)
(PMID:11359874)
RGD PMID:11359874, PMID:11359874 MGI:MGI:5902690, RGD:12907555 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G App amyloid beta precursor protein ISO (PMID:18723082) RGD PMID:18723082 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor ISO
ISS
(PMID:25639753)
GO_REF:0000024
RGD
UniProt
PMID:25639753 GO_REF:0000024 NCBI chr 3:72,540,538...72,544,183
Ensembl chr 3:72,540,538...72,544,182
JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      signal transduction 7015
        negative regulation of signal transduction 1243
          negative adaptation of signaling pathway 30
            desensitization of G protein-coupled receptor signaling pathway 30
              G protein-coupled receptor internalization + 19
              desensitization of G protein-coupled receptor signaling pathway by arrestin 3
              inhibitory G protein-coupled receptor phosphorylation + 3
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            regulation of signal transduction 2997
              negative regulation of signal transduction 1243
                negative adaptation of signaling pathway 30
                  desensitization of G protein-coupled receptor signaling pathway 30
                    G protein-coupled receptor internalization + 19
                    desensitization of G protein-coupled receptor signaling pathway by arrestin 3
                    inhibitory G protein-coupled receptor phosphorylation + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.