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ONTOLOGY REPORT - ANNOTATIONS


Term:desensitization of G protein-coupled receptor signaling pathway by arrestin
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Accession:GO:0002032 term browser browse the term
Definition:The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins.
Synonyms:exact_synonym: arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway;   arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway;   desensitization of G-protein coupled receptor protein signaling pathway by arrestin


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desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 ISO
ISS
(PMID:15123695)
GO_REF:0000024
RGD
HGNC
PMID:15123695 GO_REF:0000024 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
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G Adrb3 adrenoceptor beta 3 NOT ISO (PMID:15123695) RGD PMID:15123695 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Arrb2 arrestin, beta 2 IMP
ISO
(PMID:12582207) RGD PMID:12582207, PMID:20705669 RGD:5509896 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      signal transduction 7011
        negative regulation of signal transduction 1235
          negative adaptation of signaling pathway 30
            desensitization of G protein-coupled receptor signaling pathway 30
              desensitization of G protein-coupled receptor signaling pathway by arrestin 3
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            regulation of signal transduction 2934
              negative regulation of signal transduction 1235
                negative adaptation of signaling pathway 30
                  desensitization of G protein-coupled receptor signaling pathway 30
                    desensitization of G protein-coupled receptor signaling pathway by arrestin 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.