ONTOLOGY REPORT - ANNOTATIONS


Term:sprouting angiogenesis
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Accession:GO:0002040 term browser browse the term
Definition:The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.


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sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgra2 adhesion G protein-coupled receptor A2 JBrowse link 16 69,094,587 69,133,015 RGD:1624291
RGD:13792537
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:1600115
RGD:1624291
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:5688290
G Cdh13 cadherin 13 JBrowse link 19 50,848,793 51,971,618 RGD:1624291
RGD:13792537
G E2f7 E2F transcription factor 7 JBrowse link 7 53,275,659 53,318,261 RGD:1624291
RGD:1600115
G E2f8 E2F transcription factor 8 JBrowse link 1 104,185,436 104,203,683 RGD:1600115
RGD:1624291
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Esm1 endothelial cell-specific molecule 1 JBrowse link 2 45,104,392 45,113,130 RGD:1624291
RGD:1600115
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:1624291
RGD:13792537
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:1600115
RGD:13792537
RGD:1624291
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase JBrowse link 10 105,781,752 105,787,803 RGD:1624291
RGD:1600115
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:13792537
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:1624291
RGD:13792537
RGD:1600115
G Loxl2 lysyl oxidase-like 2 JBrowse link 15 51,276,022 51,365,238 RGD:1600115
RGD:1624291
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
RGD:1600115
G Nrarp Notch-regulated ankyrin repeat protein JBrowse link 3 2,396,143 2,398,697 RGD:1624291
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:1624291
G Otulin OTU deubiquitinase with linear linkage specificity JBrowse link 2 80,267,724 80,293,204 RGD:1624291
RGD:1600115
G Parva parvin, alpha JBrowse link 1 177,249,302 177,408,160 RGD:1600115
RGD:1624291
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6483775
RGD:13792537
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1624291
RGD:1600115
G Ramp2 receptor activity modifying protein 2 JBrowse link 10 89,166,170 89,168,962 RGD:1624291
RGD:1600115
G Rnf213 ring finger protein 213 JBrowse link 10 108,527,351 108,626,372 RGD:1624291
RGD:13792537
G Rspo3 R-spondin 3 JBrowse link 1 30,681,648 30,768,038 RGD:1624291
RGD:1600115
G Sema3e semaphorin 3E JBrowse link 4 17,314,745 17,594,659 RGD:1624291
RGD:1600115
G Tek TEK receptor tyrosine kinase JBrowse link 5 113,725,717 113,852,799 RGD:1624291
RGD:1600115
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1624291
RGD:13792537
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:13792537
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:13792537
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:13792537
blood vessel endothelial cell proliferation involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Bmper BMP-binding endothelial regulator JBrowse link 8 24,369,916 24,615,484 RGD:1624291
RGD:1600115
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1624291
RGD:1600115
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:1624291
RGD:1600115
G Nrarp Notch-regulated ankyrin repeat protein JBrowse link 3 2,396,143 2,398,697 RGD:1624291
RGD:13792537
G Sema5a semaphorin 5A JBrowse link 2 85,377,318 85,808,970 RGD:1624291
RGD:1600115
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1624291
cell adhesion involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rtn4 reticulon 4 JBrowse link 14 114,126,931 114,174,459 RGD:1600115
RGD:1624291
cell migration involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adtrp androgen-dependent TFPI-regulating protein JBrowse link 17 22,619,913 22,688,296 RGD:1600115
RGD:1624291
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1600115
RGD:1624291
G Clec14a C-type lectin domain containing 14A JBrowse link 6 79,303,301 79,306,443 RGD:1600115
RGD:1624291
G Efnb2 ephrin B2 JBrowse link 16 86,631,151 86,672,050 RGD:1624291
RGD:1600115
G Egr3 early growth response 3 JBrowse link 15 51,756,683 51,762,080 RGD:1624291
RGD:1600115
G Ephb4 EPH receptor B4 JBrowse link 12 22,393,338 22,418,332 RGD:1624291
RGD:1600115
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:1624291
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 JBrowse link 17 42,085,027 42,131,344 RGD:1600115
RGD:1624291
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
RGD:1600115
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1624291
RGD:1600115
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1624291
G Mia3 MIA SH3 domain ER export factor 3 JBrowse link 13 101,727,434 101,770,127 RGD:1624291
G Mmrn2 multimerin 2 JBrowse link 16 10,727,552 10,749,303 RGD:1600115
RGD:1624291
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 JBrowse link 7 142,899,358 142,920,216 RGD:1624291
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:1624291
RGD:1600115
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:1624291
RGD:1600115
G Robo1 roundabout guidance receptor 1 JBrowse link 11 9,079,291 10,146,302 RGD:1624291
RGD:1600115
G Slit2 slit guidance ligand 2 JBrowse link 14 66,831,848 67,171,491 RGD:1624291
RGD:1600115
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:1624291
RGD:1600115
G Tdgf1 teratocarcinoma-derived growth factor 1 JBrowse link 8 119,215,266 119,220,909 RGD:1624291
RGD:1600115
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1624291
endothelial tip cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:1600115
RGD:1624291
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dll4 delta like canonical Notch ligand 4 JBrowse link 3 111,135,011 111,146,746 RGD:1624291
RGD:1600115
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:1600115
RGD:1624291
G Pdcd10 programmed cell death 10 JBrowse link 2 173,966,701 174,012,730 RGD:1624291
RGD:1600115
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
negative regulation of cell adhesion involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sema6a semaphorin 6A JBrowse link 18 41,330,519 41,451,813 RGD:1624291
negative regulation of cell migration involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Card10 caspase recruitment domain family, member 10 JBrowse link 7 119,998,639 120,028,632 RGD:1600115
RGD:1624291
G Dll4 delta like canonical Notch ligand 4 JBrowse link 3 111,135,011 111,146,746 RGD:1624291
RGD:1600115
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:1624291
RGD:1600115
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:1624291
RGD:1600115
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:1624291
RGD:1600115
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:8553940
G Meox2 mesenchyme homeobox 2 JBrowse link 6 56,625,768 56,689,195 RGD:1600115
RGD:1624291
G Mmrn2 multimerin 2 JBrowse link 16 10,727,552 10,749,303 RGD:1624291
RGD:13792537
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
RGD:1600115
G Pdcd10 programmed cell death 10 JBrowse link 2 173,966,701 174,012,730 RGD:1624291
RGD:1600115
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:11053232
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1624291
RGD:1600115
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:1624291
RGD:1600115
G Stard13 StAR-related lipid transfer domain containing 13 JBrowse link 12 1,023,494 1,418,919 RGD:1624291
RGD:1600115
G Tbxa2r thromboxane A2 receptor JBrowse link 7 11,253,153 11,259,233 RGD:1600115
RGD:1624291
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
negative regulation of sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 JBrowse link 4 124,660,254 124,860,997 RGD:1624291
G Creb3l1 cAMP responsive element binding protein 3-like 1 JBrowse link 3 80,892,433 80,933,283 RGD:1600115
RGD:1624291
G E2f2 E2F transcription factor 2 JBrowse link 5 154,516,611 154,540,228 RGD:1600115
RGD:1624291
G Epn1 Epsin 1 JBrowse link 1 72,294,153 72,310,217 RGD:1600115
RGD:1624291
G Epn2 epsin 2 JBrowse link 10 47,795,496 47,857,373 RGD:1600115
RGD:1624291
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:10402115
G Klf2 Kruppel-like factor 2 JBrowse link 16 19,223,087 19,225,037 RGD:1600115
RGD:1624291
G Sema6a semaphorin 6A JBrowse link 18 41,330,519 41,451,813 RGD:1624291
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:12904914
G Stard13 StAR-related lipid transfer domain containing 13 JBrowse link 12 1,023,494 1,418,919 RGD:1624291
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:1624291
RGD:1600115
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1624291
G Aplnr apelin receptor JBrowse link 3 72,540,538 72,544,183 RGD:1624291
RGD:1600115
G Fgfbp1 fibroblast growth factor binding protein 1 JBrowse link 14 71,647,429 71,650,359 RGD:1600115
RGD:1624291
G Gata2 GATA binding protein 2 JBrowse link 4 120,129,028 120,142,490 RGD:1600115
RGD:1624291
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1600115
RGD:1624291
G Jcad junctional cadherin 5 associated JBrowse link 17 55,667,754 55,709,738 RGD:1624291
RGD:13792537
G LOC100912649 uncharacterized LOC100912649 RGD:1600115
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B JBrowse link 3 155,160,474 155,267,002 RGD:1624291
RGD:1600115
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1624291
positive regulation of cell migration involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:1600115
RGD:1624291
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:1624291
RGD:13792537
G Cib1 calcium and integrin binding 1 JBrowse link 1 142,014,962 142,020,461 RGD:1624291
RGD:1600115
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:1600115
RGD:1624291
G Fgfbp1 fibroblast growth factor binding protein 1 JBrowse link 14 71,647,429 71,650,359 RGD:1600115
RGD:1624291
G Foxc2 forkhead box C2 JBrowse link 19 53,044,379 53,047,081 RGD:1624291
RGD:1600115
G Gata2 GATA binding protein 2 JBrowse link 4 120,129,028 120,142,490 RGD:1600115
RGD:1624291
G Hdac7 histone deacetylase 7 JBrowse link 7 139,280,396 139,319,108 RGD:1624291
RGD:1600115
G Hdac9 histone deacetylase 9 JBrowse link 6 53,487,367 54,358,694 RGD:1624291
RGD:1600115
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1600115
RGD:1624291
G Jcad junctional cadherin 5 associated JBrowse link 17 55,667,754 55,709,738 RGD:1624291
RGD:1600115
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1624291
RGD:1600115
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:1600115
RGD:1624291
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:1624291
RGD:1600115
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha JBrowse link 1 185,210,922 185,326,314 RGD:1600115
RGD:1624291
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:1600115
RGD:1624291
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:5135054
G Rhoj ras homolog family member J JBrowse link 6 98,284,361 98,367,122 RGD:1600115
RGD:1624291
G Srpx2 sushi-repeat-containing protein, X-linked 2 JBrowse link X 104,734,035 104,760,658 RGD:1624291
RGD:1600115
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1624291
positive regulation of sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmper BMP-binding endothelial regulator JBrowse link 8 24,369,916 24,615,484 RGD:1624291
RGD:1600115
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:1600115
RGD:1624291
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:1624291
RGD:1600115
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:1600115
RGD:1624291
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:12904963
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:12904963
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1600115
RGD:1624291
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1624291
RGD:1600115
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:1624291
RGD:1600115
G Jcad junctional cadherin 5 associated JBrowse link 17 55,667,754 55,709,738 RGD:1624291
G Jmjd8 jumonji domain containing 8 JBrowse link 10 15,195,954 15,198,870 RGD:1600115
RGD:1624291
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:1600115
RGD:1624291
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1600115
RGD:1624291
G Pkm pyruvate kinase M1/2 JBrowse link 8 64,480,963 64,502,957 RGD:1600115
RGD:1624291
G Pkm_v1 pyruvate kinase M1/2, variant 1 RGD:1600115
G Pkm_v2 pyruvate kinase M1/2, variant 2 RGD:1600115
G S100a1 S100 calcium binding protein A1 JBrowse link 2 189,900,505 189,905,348 RGD:1600115
RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:12879408
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:1624291
RGD:1600115
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1624291
regulation of cell migration involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fbxw7 F-box and WD repeat domain containing 7 JBrowse link 2 184,230,191 184,309,805 RGD:1624291
RGD:1600115
G Nr2e1 nuclear receptor subfamily 2, group E, member 1 JBrowse link 20 47,286,843 47,306,318 RGD:1624291
RGD:1600115
regulation of sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 carcinoembryonic antigen related cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Fgf16 fibroblast growth factor 16 JBrowse link X 76,786,728 76,796,311 RGD:1624291
G Fgf18 fibroblast growth factor 18 JBrowse link 10 18,047,109 18,082,290 RGD:1624291
G Glul glutamate-ammonia ligase JBrowse link 13 71,331,052 71,340,207 RGD:1600115
RGD:1624291
G Rhoj ras homolog family member J JBrowse link 6 98,284,361 98,367,122 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17941
    developmental process 6374
      anatomical structure formation involved in morphogenesis 1167
        angiogenesis 498
          sprouting angiogenesis 120
            angiogenic sprout fusion + 2
            blood vessel endothelial cell proliferation involved in sprouting angiogenesis + 19
            cell migration involved in sprouting angiogenesis + 55
            endothelial stalk cell fate specification 0
            endothelial tip cell fate specification 1
            negative regulation of sprouting angiogenesis + 27
            positive regulation of sprouting angiogenesis + 43
            regulation of sprouting angiogenesis + 75
Path 2
Term Annotations click to browse term
  biological_process 17941
    developmental process 6374
      anatomical structure development 5982
        multicellular organism development 5475
          system development 5028
            circulatory system development 1184
              cardiovascular system development 753
                vasculature development 739
                  blood vessel development 703
                    blood vessel morphogenesis 603
                      angiogenesis 498
                        sprouting angiogenesis 120
                          angiogenic sprout fusion + 2
                          blood vessel endothelial cell proliferation involved in sprouting angiogenesis + 19
                          cell migration involved in sprouting angiogenesis + 55
                          endothelial stalk cell fate specification 0
                          endothelial tip cell fate specification 1
                          negative regulation of sprouting angiogenesis + 27
                          positive regulation of sprouting angiogenesis + 43
                          regulation of sprouting angiogenesis + 75
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.