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ONTOLOGY REPORT - ANNOTATIONS


Term:lens development in camera-type eye
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Accession:GO:0002088 term browser browse the term
Definition:The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
Synonyms:exact_synonym: lens development;   lens development in camera-style eye


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lens development in camera-type eye term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07033887.1 RGD:13792537
G Birc7 baculoviral IAP repeat-containing 7 JBrowse link 3 176,438,335 176,443,864 RGD:1624291
G Casp6 caspase 6 JBrowse link 2 235,341,326 235,353,715 RGD:2301319
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:724665
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:724665
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:1624291
RGD:1600115
G Cryaa crystallin, alpha A JBrowse link 20 10,438,444 10,442,189 RGD:1600991
RGD:1624291
G Cryab crystallin, alpha B JBrowse link 8 55,178,543 55,182,546 RGD:1624291
G Cryba1 crystallin, beta A1 JBrowse link 10 65,160,777 65,167,504 RGD:1298814
RGD:13792537
G Cryba2 crystallin, beta A2 JBrowse link 9 82,151,056 82,154,266 RGD:1624291
RGD:13792537
G Cryba4 crystallin, beta A4 JBrowse link 12 50,407,843 50,414,434 RGD:13792537
G Crybb1 crystallin, beta B1 JBrowse link 12 50,390,939 50,404,550 RGD:13792537
G Crybb2 crystallin, beta B2 JBrowse link 12 49,577,580 49,588,555 RGD:13792537
G Crybb3 crystallin, beta B3 JBrowse link 12 49,564,991 49,571,008 RGD:13792537
G Crybg3 crystallin beta-gamma domain containing 3 JBrowse link 11 42,895,610 43,006,568 RGD:13792537
G Cryga crystallin, gamma A JBrowse link 9 71,828,308 71,855,900 RGD:2303725
RGD:13792537
RGD:1624291
G Crygb crystallin, gamma B JBrowse link 9 71,796,204 71,798,265 RGD:2303725
RGD:13792537
RGD:1624291
G Crygc crystallin, gamma C JBrowse link 9 71,786,246 71,788,281 RGD:2303725
RGD:13792537
G Crygd crystallin, gamma D JBrowse link 9 71,776,568 71,778,323 RGD:2303725
RGD:13792537
RGD:1624291
G Cryge crystallin, gamma E JBrowse link 9 71,764,317 71,767,045 RGD:2303725
RGD:13792537
G Crygf crystallin, gamma F JBrowse link 9 72,933,304 72,935,468 RGD:2303725
RGD:13792537
G Crygn crystallin, gamma N JBrowse link 4 6,900,811 6,909,167 RGD:13792537
G Crygs crystallin, gamma S JBrowse link 11 81,796,891 81,802,172 RGD:1624291
RGD:13792537
G Ctns cystinosin, lysosomal cystine transporter JBrowse link 10 59,749,250 59,772,475 RGD:1624291
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:1624291
RGD:1600115
G Fat1 FAT atypical cadherin 1 JBrowse link 16 50,372,150 50,501,716 RGD:1624291
G Foxe3 forkhead box E3 JBrowse link 5 133,724,796 133,725,656 RGD:1624291
RGD:10047226
RGD:1600115
G Frs2 fibroblast growth factor receptor substrate 2 JBrowse link 7 60,128,506 60,210,482 RGD:1624291
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:1624291
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:1624291
G Gja8 gap junction protein, alpha 8 JBrowse link 2 199,050,854 199,052,470 RGD:1624291
G Gje1 gap junction protein, epsilon 1 JBrowse link 1 8,883,767 8,887,721 RGD:1624291
G Lim2 lens intrinsic membrane protein 2 JBrowse link 1 98,495,082 98,501,248 RGD:1624291
G Maf MAF bZIP transcription factor JBrowse link 19 48,179,826 48,200,995 RGD:1624291
G Med1 mediator complex subunit 1 JBrowse link 10 86,101,560 86,145,271 RGD:1624291
RGD:1600115
G Mip major intrinsic protein of lens fiber JBrowse link 7 2,635,743 2,642,995 RGD:1624291
RGD:1600115
G Nhs NHS actin remodeling regulator JBrowse link X 34,312,102 34,675,912 RGD:1624291
RGD:13792537
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:1624291
RGD:1600115
G Pds5b PDS5 cohesin associated factor B JBrowse link 12 659,995 794,042 RGD:1600115
G Pitx3 paired-like homeodomain 3 JBrowse link 1 265,886,766 265,899,947 RGD:1600115
RGD:1624291
G Prox1 prospero homeobox 1 JBrowse link 13 108,382,536 108,444,107 RGD:1624291
G Pygo2 pygopus family PHD finger 2 JBrowse link 2 188,757,167 188,762,285 RGD:1624291
G Six3 SIX homeobox 3 JBrowse link 6 8,886,730 8,891,094 RGD:1624291
G Six5 SIX homeobox 5 JBrowse link 1 80,000,106 80,005,303 RGD:1624291
G Slitrk6 SLIT and NTRK-like family, member 6 JBrowse link 15 95,507,632 95,514,259 RGD:1624291
G Tbc1d20 TBC1 domain family, member 20 JBrowse link 3 147,772,006 147,790,946 RGD:1624291
G Tbc1d32 TBC1 domain family, member 32 JBrowse link 20 37,463,879 37,701,268 RGD:1624291
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1624291
lens fiber cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bfsp1 beaded filament structural protein 1 JBrowse link 3 137,935,345 137,992,652 RGD:1624291
RGD:13792537
RGD:1600115
G Bfsp2 beaded filament structural protein 2 JBrowse link 8 111,908,614 111,965,889 RGD:1624291
G Crygb crystallin, gamma B JBrowse link 9 71,796,204 71,798,265 RGD:1624291
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:1624291
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:1624291
G Frs2 fibroblast growth factor receptor substrate 2 JBrowse link 7 60,128,506 60,210,482 RGD:1624291
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:1624291
G Tmod1 tropomodulin 1 JBrowse link 5 61,635,244 61,712,052 RGD:1624291
RGD:1600115
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:1624291
RGD:1600115
lens fiber cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crygd crystallin, gamma D JBrowse link 9 71,776,568 71,778,323 RGD:1601018
RGD:1624291
G Fzr1 fizzy and cell division cycle 20 related 1 JBrowse link 7 11,201,690 11,213,614 RGD:1624291
G Kdm5b lysine demethylase 5B JBrowse link 13 51,384,371 51,455,392 RGD:9587771
G Maf MAF bZIP transcription factor JBrowse link 19 48,179,826 48,200,995 RGD:1600115
RGD:13792537
RGD:1624291
G Nf2 neurofibromin 2 JBrowse link 14 84,996,905 85,088,547 RGD:1600115
RGD:1624291
G Ntrk3 neurotrophic receptor tyrosine kinase 3 JBrowse link 1 139,890,537 140,262,503 RGD:1624291
G Pitx3 paired-like homeodomain 3 JBrowse link 1 265,886,766 265,899,947 RGD:1624291
G Six3 SIX homeobox 3 JBrowse link 6 8,886,730 8,891,094 RGD:1624291
G Skil SKI-like proto-oncogene JBrowse link 2 115,862,932 115,891,304 RGD:1624291
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:2315033
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1624291
G Tdrd7 tudor domain containing 7 JBrowse link 5 61,557,909 61,631,719 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
lens fiber cell morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abi2 abl-interactor 2 JBrowse link 9 67,234,612 67,284,504 RGD:1624291
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:1600115
RGD:1624291
G Cryaa crystallin, alpha A JBrowse link 20 10,438,444 10,442,189 RGD:1624291
G Crygb crystallin, gamma B JBrowse link 9 71,796,204 71,798,265 RGD:1624291
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1624291
G Prox1 prospero homeobox 1 JBrowse link 13 108,382,536 108,444,107 RGD:1624291
G Tbc1d20 TBC1 domain family, member 20 JBrowse link 3 147,772,006 147,790,946 RGD:1624291
lens induction in camera-type eye term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Hipk1 homeodomain interacting protein kinase 1 JBrowse link 2 206,224,015 206,274,910 RGD:1624291
RGD:1600115
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:1624291
G Pou2f1 POU class 2 homeobox 1 JBrowse link 13 84,075,316 84,217,368 RGD:1624291
G Six3 SIX homeobox 3 JBrowse link 6 8,886,730 8,891,094 RGD:1624291
G Sox2 SRY-box transcription factor 2 JBrowse link 2 121,165,137 121,167,545 RGD:1624291
G Tfap2a transcription factor AP-2 alpha JBrowse link 17 24,653,342 24,670,457 RGD:1624291
lens morphogenesis in camera-type eye term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcar3 BCAR3 adaptor protein, NSP family member JBrowse link 2 226,563,050 226,679,449 RGD:1624291
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 JBrowse link 1 12,823,363 12,825,806 RGD:1624291
G Cryaa crystallin, alpha A JBrowse link 20 10,438,444 10,442,189 RGD:1624291
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:1624291
G Lctl lactase-like JBrowse link 8 69,070,340 69,090,405 RGD:1624291
G Meis1 Meis homeobox 1 JBrowse link 14 103,182,178 103,321,809 RGD:1624291
G Nectin1 nectin cell adhesion molecule 1 JBrowse link 8 48,094,233 48,198,499 RGD:1624291
G Nectin3 nectin cell adhesion molecule 3 JBrowse link 11 57,897,879 57,995,193 RGD:1624291
G Pitx3 paired-like homeodomain 3 JBrowse link 1 265,886,766 265,899,947 RGD:1624291
RGD:1600115
G Prox1 prospero homeobox 1 JBrowse link 13 108,382,536 108,444,107 RGD:1624291
G Ski SKI proto-oncogene JBrowse link 5 172,556,196 172,623,878 RGD:1624291
G Sox1 SRY-box transcription factor 1 RGD:1624291
G Sox11 SRY-box transcription factor 11 JBrowse link 6 46,629,967 46,631,988 RGD:1624291
RGD:1600115
G Tdrd7 tudor domain containing 7 JBrowse link 5 61,557,909 61,631,719 RGD:1624291
RGD:1600115
G Tfap2a transcription factor AP-2 alpha JBrowse link 17 24,653,342 24,670,457 RGD:1624291
negative regulation of lens fiber cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxe3 forkhead box E3 JBrowse link 5 133,724,796 133,725,656 RGD:10047273
RGD:1624291
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:1624291
G Spred2 sprouty-related, EVH1 domain containing 2 JBrowse link 14 104,268,362 104,290,206 RGD:1600115
RGD:1624291
G Spred3 sprouty-related, EVH1 domain containing 3 JBrowse link 1 88,101,213 88,112,719 RGD:1624291
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link 2 124,400,689 124,405,331 RGD:1624291
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:1624291
positive regulation of lens epithelial cell proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxe3 forkhead box E3 JBrowse link 5 133,724,796 133,725,656 RGD:1624291
RGD:10047273
RGD:10047255
G Sox11 SRY-box transcription factor 11 JBrowse link 6 46,629,967 46,631,988 RGD:1624291
RGD:1600115
positive regulation of lens fiber cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:1600115
RGD:1624291
G Zeb2 zinc finger E-box binding homeobox 2 JBrowse link 3 29,857,289 29,985,932 RGD:1624291
regulation of lens fiber cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:1624291
G Cdkn1c cyclin-dependent kinase inhibitor 1C JBrowse link 1 216,661,067 216,663,791 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    developmental process 6734
      anatomical structure development 6180
        lens development in camera-type eye 93
          lens epithelial cell proliferation + 2
          lens fiber cell differentiation + 38
          lens morphogenesis in camera-type eye + 27
Path 2
Term Annotations click to browse term
  biological_process 19858
    developmental process 6734
      anatomical structure development 6180
        multicellular organism development 5638
          system development 5213
            animal organ development 3974
              sensory organ development 688
                eye development 455
                  camera-type eye development 406
                    lens development in camera-type eye 93
                      lens epithelial cell proliferation + 2
                      lens fiber cell differentiation + 38
                      lens morphogenesis in camera-type eye + 27
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.