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ONTOLOGY REPORT - ANNOTATIONS


Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome


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podosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actb actin, beta JBrowse link 12 13,715,843 13,718,813 RGD:11541102
G Actr3 actin related protein 3 JBrowse link 13 41,695,520 41,738,622 RGD:2306207
RGD:2306209
G Adam8 ADAM metallopeptidase domain 8 JBrowse link 1 212,317,510 212,332,895 RGD:1624291
G Afap1l1 actin filament associated protein 1-like 1 JBrowse link 18 57,052,659 57,114,589 RGD:1600115
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 JBrowse link 2 187,964,100 188,022,847 RGD:1624291
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 JBrowse link 7 104,670,076 104,951,090 RGD:1600115
RGD:13792537
RGD:1624291
G Bin2 bridging integrator 2 JBrowse link 7 142,273,832 142,304,731 RGD:1624291
RGD:13792537
RGD:1600115
G Ccn5 cellular communication network factor 5 JBrowse link 3 160,207,969 160,219,316 RGD:14390054
G Cttn cortactin JBrowse link 1
1
217,602,698
215,255,385
217,638,196
215,290,882
RGD:1624291
G Dbnl drebrin-like JBrowse link 14 86,029,335 86,044,364 RGD:1624291
RGD:1600115
G Fermt3 fermitin family member 3 JBrowse link 1 222,254,183 222,272,775 RGD:1624291
G Fscn1 fascin actin-bundling protein 1 JBrowse link 12 13,655,459 13,668,595 RGD:1624291
RGD:1600115
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:1624291
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:1600115
G Kif9 kinesin family member 9 JBrowse link 8 118,737,739 118,795,190 RGD:1624291
G Lcp1 lymphocyte cytosolic protein 1 JBrowse link 15 57,170,566 57,277,811 RGD:1624291
G Lpxn leupaxin JBrowse link 1 229,642,437 229,674,129 RGD:1624291
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:1624291
G Palld palladin, cytoskeletal associated protein JBrowse link 16 31,865,712 31,948,168 RGD:2325783
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 JBrowse link 4 10,631,129 10,702,390 RGD:1624291
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 JBrowse link 9 11,031,847 11,055,285 RGD:1600115
G Sh3pxd2a SH3 and PX domains 2A JBrowse link 1 267,039,654 267,245,868 RGD:1624291
G Sh3pxd2b SH3 and PX domains 2B JBrowse link 10 17,209,152 17,296,449 RGD:1624291
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1624291
G Tpm3 tropomyosin 3 JBrowse link 2 189,423,534 189,451,340 RGD:1624291
G Tpm4 tropomyosin 4 JBrowse link 16 19,385,810 19,399,851 RGD:1624291
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:1624291
G Vcl vinculin JBrowse link 15 3,455,211 3,544,738 RGD:1624291
RGD:1600115
G Wdr1 WD repeat domain 1 JBrowse link 14 76,990,014 77,023,739 RGD:1600115
podosome core term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actr2 actin related protein 2 JBrowse link 14 104,338,486 104,375,840 RGD:11530035
G Actr3 actin related protein 3 JBrowse link 13 41,695,520 41,738,622 RGD:11530018
G Arpc2 actin related protein 2/3 complex, subunit 2 JBrowse link 9 81,518,163 81,548,871 RGD:2306207
podosome ring term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arpc2 actin related protein 2/3 complex, subunit 2 JBrowse link 9 81,518,163 81,548,871 RGD:2306207

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20300
    intracellular 14243
      intracellular organelle 12441
        intracellular non-membrane-bounded organelle 4837
          podosome 31
            podosome core 3
            podosome ring 1
Path 2
Term Annotations click to browse term
  cellular_component 20300
    cellular anatomical entity 19956
      organelle 12977
        non-membrane-bounded organelle 4856
          intracellular non-membrane-bounded organelle 4837
            cytoskeleton 2115
              actin cytoskeleton 518
                podosome 31
                  podosome core 3
                  podosome ring 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.