Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:activation of innate immune response
go back to main search page
Accession:GO:0002218 term browser browse the term
Definition:Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
Synonyms:alt_id: GO:0002219


show annotations for term's descendants           Sort by:
 
activation of innate immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07009373.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 2:94,902,666...94,903,226 JBrowse link
G AABR07019870.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr13:5,480,150...5,480,629 JBrowse link
G AABR07025074.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr16:27,472,051...27,472,687 JBrowse link
G AABR07029613.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr10:40,994,237...40,994,872 JBrowse link
G AABR07035218.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr12:7,081,895...7,094,002 JBrowse link
G AABR07054355.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 3:149,741,312...149,741,953 JBrowse link
G AABR07054358.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 3:149,790,856...149,791,497 JBrowse link
G AABR07060165.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:60,547,401...60,548,021 JBrowse link
G AABR07060287.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:66,091,641...66,092,259 JBrowse link
G AABR07067274.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 9:37,593,032...37,593,603 JBrowse link
G AC094217.2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:31,436,712...31,437,203 JBrowse link
G AC108595.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 7:132,983,472...132,984,110 JBrowse link
G Aim2 absent in melanoma 2 ISO
IBA
(MGI:MGI:3839523|PMID:19158676)
PMID:21873635
(PMID:19158675), (PMID:19158676), (PMID:19158679)
RGD PMID:19158675, PMID:19158676, PMID:19158679, PMID:21873635 MGI:MGI:3839523, RGD:13792537 NCBI chr13:91,919,834...91,963,080
Ensembl chr13:91,954,138...91,962,588
JBrowse link
G Cgas cyclic GMP-AMP synthase ISO
IBA
(MGI:MGI:5487472|PMID:23258413), (MGI:MGI:5505711|PMID:23929945), (MGI:MGI:5908326|PMID:24077100)
PMID:21873635
(PMID:23258413), (PMID:23929945), (PMID:24077100), (PMID:26046437), (PMID:28363908), (PMID:30007416)
RGD PMID:23258413, PMID:23929945, PMID:24077100, PMID:26046437, PMID:28363908, PMID:30007416, PMID:21873635 MGI:MGI:5487472, MGI:MGI:5505711, MGI:MGI:5908326, RGD:13792537 NCBI chr 8:85,789,515...85,804,008
Ensembl chr 8:85,789,763...85,803,433
JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 ISO (PMID:28712728) RGD PMID:28712728 NCBI chr10:91,200,874...91,202,986
Ensembl chr10:91,200,874...91,202,984
JBrowse link
G Hmg1l1 high-mobility group (nonhistone chromosomal) protein 1-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:59,984,234...59,985,494
Ensembl chr19:59,984,234...59,985,494
JBrowse link
G Hmgb1 high mobility group box 1 ISO
IBA
(PMID:24971542)
PMID:21873635
RGD PMID:24971542, PMID:21873635 RGD:13792537 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgb1-ps3 high mobility group box 1, pseudogene 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:132,982,959...132,984,167 JBrowse link
G LOC100911637 high mobility group protein B1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:149,741,055...149,741,953 JBrowse link
G LOC102556096 pyrin domain-containing protein 3-like IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:91,977,441...91,981,426
Ensembl chr13:91,980,114...91,981,432
JBrowse link
G LOC108349189 high mobility group protein B1 pseudogene IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:115,351,012...115,351,755
Ensembl chr  X:115,351,114...115,351,755
JBrowse link
G LOC108350839 high mobility group protein B1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:92,431,517...92,432,354
Ensembl chr 4:92,431,710...92,432,354
JBrowse link
G LOC690521 similar to High mobility group protein 1 (HMG-1) (High mobility group protein B1) (Amphoterin) (Heparin-binding protein p30) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:149,790,599...149,791,497 JBrowse link
G Matr3 matrin 3 ISO (PMID:28712728) RGD PMID:28712728 NCBI chr18:28,351,691...28,390,764
Ensembl chr18:28,361,283...28,390,717
JBrowse link
G Mavs mitochondrial antiviral signaling protein ISO (PMID:18818105) RGD PMID:18818105 NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
JBrowse link
G Mnda myeloid cell nuclear differentiation antigen IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:92,073,664...92,091,335
Ensembl chr13:92,073,668...92,089,980
JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 ISO
ISS
(MGI:MGI:3662990|PMID:16648852)
GO_REF:0000024
RGD
UniProt
PMID:16648852 GO_REF:0000024, MGI:MGI:3662990 NCBI chr 6:22,167,874...22,194,755
Ensembl chr 6:22,167,919...22,194,250
JBrowse link
G Nono non-POU domain containing, octamer-binding ISO (PMID:28712728) RGD PMID:28712728 NCBI chr  X:71,324,365...71,342,225
Ensembl chr  X:71,324,365...71,342,225
JBrowse link
G Pqbp1 polyglutamine binding protein 1 ISO
IEA
ISS
(PMID:26046437)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:26046437 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:15,448,570...15,453,130
Ensembl chr  X:15,348,138...15,453,130
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO (PMID:28712728) RGD PMID:28712728 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Pspc1 paraspeckle component 1 ISO (PMID:28712728) RGD PMID:28712728 NCBI chr15:36,946,914...37,030,273
Ensembl chr15:36,950,257...37,030,281
JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:21575908)
(MGI:MGI:3839029|PMID:19158675)
RGD PMID:19158675, PMID:21575908 MGI:MGI:3839029 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rbm14 RNA binding motif protein 14 ISO
IBA
(PMID:28712728)
PMID:21873635
RGD PMID:28712728, PMID:21873635 RGD:13792537 NCBI chr 1:220,048,740...220,067,124
Ensembl chr 1:220,048,873...220,067,124
JBrowse link
G RGD1563668 similar to High mobility group protein 1 (HMG-1) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:40,994,237...40,994,990 JBrowse link
G RGD1565762 similar to High mobility group protein 1 (HMG-1) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:5,480,069...5,480,782 JBrowse link
G Sfpq splicing factor proline and glutamine rich ISO (PMID:28712728) RGD PMID:28712728 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
JBrowse link
G Sin3a SIN3 transcription regulator family member A ISO (PMID:22783022) RGD PMID:22783022 NCBI chr 8:61,748,590...61,803,314
Ensembl chr 8:61,762,768...61,803,099
JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 ISO
IBA
(PMID:18818105)
PMID:21873635
(MGI:MGI:5487473|PMID:23258412), (MGI:MGI:5487515|PMID:21947006)
RGD PMID:18818105, PMID:21947006, PMID:23258412, PMID:21873635 MGI:MGI:5487473, MGI:MGI:5487515, RGD:13792537 NCBI chr18:28,529,537...28,535,828
Ensembl chr18:28,529,576...28,535,828
JBrowse link
G Tbk1 TANK-binding kinase 1 ISO MGI:MGI:3046789 (MGI:MGI:3530402|PMID:15661922) RGD PMID:15661922 MGI:MGI:3530402 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Tlr4 toll-like receptor 4 ISO
IEA
MGI:MGI:1860885 (MGI:MGI:3530402|PMID:15661922)
GO_REF:0000107
RGD
Ensembl
PMID:15661922 GO_REF:0000107, MGI:MGI:3530402 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr9 toll-like receptor 9 ISO (MGI:MGI:5887188|PMID:25686612) RGD PMID:25686612 MGI:MGI:5887188 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Trim5 tripartite motif-containing 5 ISO (PMID:21512573) RGD PMID:21512573 NCBI chr 1:169,446,774...169,463,760
Ensembl chr 1:169,446,805...169,534,896
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 ISO (PMID:28712728) RGD PMID:28712728 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 ISO (PMID:28712728) RGD PMID:28712728 NCBI chr 7:123,259,881...123,280,613
Ensembl chr 7:123,259,761...123,280,612
JBrowse link
G Zbp1 Z-DNA binding protein 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:6434626|PMID:32296175), (MGI:MGI:6436412|PMID:32200799)
UniProt
RGD
PMID:32200799, PMID:32296175 GO_REF:0000024, MGI:MGI:6434626, MGI:MGI:6436412 NCBI chr 3:171,276,062...171,292,062
Ensembl chr 3:171,276,062...171,286,537
JBrowse link
G Zcchc3 zinc finger CCHC-type containing 3 ISO (PMID:30135424), (PMID:30193849)
(MGI:MGI:6209107|PMID:30135424), (MGI:MGI:6271678|PMID:30193849)
RGD PMID:30135424, PMID:30193849 MGI:MGI:6209107, MGI:MGI:6271678 NCBI chr 3:147,877,321...147,881,434
Ensembl chr 3:147,878,936...147,880,138
JBrowse link
cell surface pattern recognition receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcna ficolin A ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 3:2,850,006...2,853,230
Ensembl chr 3:2,849,984...2,853,272
JBrowse link
G Fcnb ficolin B ISO (PMID:21037097) RGD PMID:21037097 NCBI chr 3:6,617,816...6,626,193
Ensembl chr 3:6,617,751...6,626,284
JBrowse link
G Ffar2 free fatty acid receptor 2 ISO
ISS
(PMID:21037097)
GO_REF:0000024
RGD
UniProt
PMID:21037097 GO_REF:0000024 NCBI chr 1:89,268,197...89,271,942
Ensembl chr 1:89,268,938...89,269,930
JBrowse link
G Tlr2 toll-like receptor 2 ISO MGI:MGI:2178675 (MGI:MGI:3042099|PMID:12719478) RGD PMID:12719478 MGI:MGI:3042099 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
innate immune response-activating signal transduction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr4 toll-like receptor 4 IMP RGD PMID:19226379 RGD:2312509 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
stimulatory C-type lectin receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klre1 killer cell lectin-like receptor, family E, member 1 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:163,346,684...163,355,050
Ensembl chr 4:163,349,125...163,354,976
JBrowse link
G Klrk1 killer cell lectin like receptor K1 ISO
IEA
(MGI:MGI:2450811|PMID:12645935)
GO_REF:0000107
RGD
Ensembl
PMID:12645935 GO_REF:0000107, MGI:MGI:2450811 NCBI chr 4:163,392,652...163,403,735
Ensembl chr 4:163,393,217...163,403,653
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    immune system process 2837
      activation of immune response 417
        activation of innate immune response 52
          induced systemic resistance, ethylene mediated signaling pathway 0
          induced systemic resistance, jasmonic acid mediated signaling pathway 0
          innate immune response-activating signal transduction + 7
Path 2
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      response to biotic stimulus 1738
        response to external biotic stimulus 1706
          response to other organism 1702
            defense response to other organism 1113
              innate immune response 829
                regulation of innate immune response 220
                  positive regulation of innate immune response 148
                    activation of innate immune response 52
                      induced systemic resistance, ethylene mediated signaling pathway 0
                      induced systemic resistance, jasmonic acid mediated signaling pathway 0
                      innate immune response-activating signal transduction + 7
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.