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ONTOLOGY REPORT - ANNOTATIONS


Term:pattern recognition receptor signaling pathway
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Accession:GO:0002221 term browser browse the term
Definition:Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
Synonyms:exact_synonym: PAMP receptor signaling pathway;   PRR signaling pathway;   pathogen receptor signaling pathway;   pathogen receptor signalling pathway


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pattern recognition receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec4e C-type lectin domain family 4, member E JBrowse link 4 156,271,087 156,276,243 RGD:1600115
RGD:1624291
G Inava innate immunity activator JBrowse link 13 53,088,438 53,108,713 RGD:1624291
G Lacc1 laccase domain containing 1 JBrowse link 15 59,199,537 59,217,200 RGD:1624291
G Nod1 nucleotide-binding oligomerization domain containing 1 JBrowse link 4 85,123,965 85,175,206 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
cell surface pattern recognition receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fcna ficolin A JBrowse link 3 2,850,006 2,853,230 RGD:1600115
G Fcnb ficolin B JBrowse link 3 6,617,816 6,626,193 RGD:1624291
G Ffar2 free fatty acid receptor 2 JBrowse link 1 89,268,197 89,271,942 RGD:1624291
RGD:1600115
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alpk1 alpha-kinase 1 JBrowse link 2 231,997,360 232,117,471 RGD:1624291
G Tifa TRAF-interacting protein with forkhead-associated domain JBrowse link 2 232,104,394 232,137,425 RGD:1600115
RGD:13792537
RGD:1624291
MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifih1 interferon induced with helicase C domain 1 JBrowse link 3 48,557,696 48,604,097 RGD:1624291
MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrfip2 LRR binding FLII interacting protein 2 JBrowse link 8 119,381,666 119,484,125 RGD:1624291
MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:1624291
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:1600115
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:1600115
G Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:1624291
G Reg3g regenerating family member 3 gamma JBrowse link 4 109,529,679 109,532,234 RGD:1624291
RGD:1600115
G Tlr1 toll-like receptor 1 JBrowse link 14 45,062,662 45,065,014 RGD:1600115
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1600115
RGD:1624291
G Tlr5 toll-like receptor 5 JBrowse link 13 101,364,784 101,385,764 RGD:1600115
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1624291
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:1600115
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:1600115
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
G Tnip1 TNFAIP3 interacting protein 1 JBrowse link 10 40,255,776 40,303,092 RGD:1624291
MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrfip2 LRR binding FLII interacting protein 2 JBrowse link 8 119,381,666 119,484,125 RGD:1624291
G Ticam1 toll-like receptor adaptor molecule 1 JBrowse link 9 10,780,185 10,790,280 RGD:1624291
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1600115
G Tnip3 TNFAIP3 interacting protein 3 JBrowse link 4 96,386,207 96,490,517 RGD:1624291
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Riok3 RIO kinase 3 JBrowse link 18 3,565,166 3,590,739 RGD:1624291
G Tkfc triokinase and FMN cyclase JBrowse link 1 226,642,901 226,657,698 RGD:1624291
RGD:1600115
negative regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:1624291
G Cd300lf Cd300 molecule-like family member F JBrowse link 10 103,669,781 103,690,584 RGD:1624291
RGD:1600115
negative regulation of MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sarm1 sterile alpha and TIR motif containing 1 JBrowse link 10 65,742,343 65,766,050 RGD:1600115
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Erbin erbb2 interacting protein JBrowse link 2 33,880,860 33,952,806 RGD:1624291
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:13792537
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
negative regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:1600115
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G Gpatch3 G patch domain containing 3 JBrowse link 5 151,796,456 151,806,007 RGD:1624291
RGD:13792537
G Nlrx1 NLR family member X1 JBrowse link 8 48,583,559 48,600,203 RGD:1624291
RGD:1600115
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link 10 109,553,518 109,610,087 RGD:1600115
RGD:1624291
G Rnf125 ring finger protein 125 JBrowse link 18 15,193,226 15,225,454 RGD:1624291
G Sec14l1 SEC14-like lipid binding 1 JBrowse link 10 106,065,712 106,112,859 RGD:1624291
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 JBrowse link 11 86,304,836 86,328,478 RGD:1624291
RGD:1600115
negative regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acod1 aconitate decarboxylase 1 JBrowse link 15 93,612,968 93,622,322 RGD:1624291
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1624291
RGD:1600115
G Mfhas1 malignant fibrous histiocytoma amplified sequence 1 JBrowse link 16 60,120,457 60,208,550 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1624291
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:1624291
RGD:1600115
negative regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acod1 aconitate decarboxylase 1 JBrowse link 15 93,612,968 93,622,322 RGD:1624291
G Bpifb1 BPI fold containing family B, member 1 JBrowse link 3 149,668,099 149,702,399 RGD:1624291
RGD:13792537
RGD:1600115
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
RGD:1624291
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1624291
RGD:1600115
G Mfhas1 malignant fibrous histiocytoma amplified sequence 1 JBrowse link 16 60,120,457 60,208,550 RGD:1624291
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 JBrowse link 10 86,683,875 86,690,815 RGD:1624291
RGD:1600115
G Rab7b Rab7b, member RAS oncogene family JBrowse link 13 48,456,143 48,483,714 RGD:1624291
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:1624291
negative regulation of toll-like receptor 5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
negative regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gramd4 GRAM domain containing 4 JBrowse link 7 126,939,819 127,013,455 RGD:1624291
RGD:13792537
G Ptprs protein tyrosine phosphatase, receptor type, S JBrowse link 9 10,585,360 10,646,205 RGD:1600115
RGD:1624291
G Rab7b Rab7b, member RAS oncogene family JBrowse link 13 48,456,143 48,483,714 RGD:1624291
negative regulation of toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
G Cactin cactin, spliceosome C complex subunit JBrowse link 7 11,258,526 11,266,509 RGD:1624291
G Gps2 G protein pathway suppressor 2 JBrowse link 10 56,524,327 56,527,447 RGD:1624291
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:1624291
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:1624291
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 JBrowse link 3 101,051,960 101,152,119 RGD:1624291
RGD:1600115
G Lrrc14 leucine rich repeat containing 14 JBrowse link 7 117,773,219 117,779,555 RGD:1600115
RGD:1624291
G Nfkbil1 NFKB inhibitor like 1 JBrowse link 20 4,823,590 4,839,202 RGD:1624291
RGD:13792537
RGD:1600115
G Nlrp6 NLR family, pyrin domain containing 6 JBrowse link 1 213,676,954 213,683,114 RGD:1624291
G Otud4 OTU deubiquitinase 4 JBrowse link 19 31,895,753 31,942,509 RGD:1624291
RGD:13792537
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1624291
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 JBrowse link 1 260,527,344 260,679,132 RGD:1624291
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B JBrowse link 5 150,925,150 150,946,994 RGD:1624291
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
G Tyro3 TYRO3 protein tyrosine kinase JBrowse link 3 111,597,102 111,616,142 RGD:1600115
RGD:1624291
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tspan6 tetraspanin 6 JBrowse link X 104,719,930 104,729,606 RGD:1624291
nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Inava innate immunity activator JBrowse link 13 53,088,438 53,108,713 RGD:1624291
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G Lacc1 laccase domain containing 1 JBrowse link 15 59,199,537 59,217,200 RGD:1624291
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Otulin OTU deubiquitinase with linear linkage specificity JBrowse link 2 80,267,724 80,293,204 RGD:1624291
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
positive regulation of MDA-5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07025140.1 RGD:1600115
G Ankrd17 ankyrin repeat domain 17 JBrowse link 14 19,291,025 19,431,521 RGD:1624291
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc46a2 solute carrier family 46, member 2 JBrowse link 5 77,165,463 77,174,177 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1624291
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1624291
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
positive regulation of pattern recognition receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 JBrowse link 3 72,090,526 72,118,406 RGD:1624291
positive regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07025140.1 RGD:1600115
G Ankrd17 ankyrin repeat domain 17 JBrowse link 14 19,291,025 19,431,521 RGD:1624291
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:1624291
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
G Pum1 pumilio RNA-binding family member 1 JBrowse link 5 148,781,239 148,911,776 RGD:1624291
G Pum2 pumilio RNA-binding family member 2 JBrowse link 6 33,786,184 33,865,693 RGD:1624291
G Trim15 tripartite motif containing 15 JBrowse link 20 2,194,293 2,203,636 RGD:1624291
G Usp15 ubiquitin specific peptidase 15 JBrowse link 7 66,595,707 66,687,707 RGD:1600115
RGD:1624291
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 JBrowse link 4 66,012,111 66,062,160 RGD:1624291
G Zcchc3 zinc finger CCHC-type containing 3 JBrowse link 3 147,877,321 147,881,434 RGD:1624291
positive regulation of toll-like receptor 13 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Treml4 triggering receptor expressed on myeloid cells-like 4 JBrowse link 9 14,668,691 14,707,122 RGD:1624291
positive regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyba cytochrome b-245 alpha chain JBrowse link 19 55,249,634 55,257,824 RGD:1624291
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
G Mfhas1 malignant fibrous histiocytoma amplified sequence 1 JBrowse link 16 60,120,457 60,208,550 RGD:1624291
G Pja2 praja ring finger ubiquitin ligase 2 JBrowse link 9 111,998,204 112,048,847 RGD:1600115
RGD:1624291
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Tlr1 toll-like receptor 1 JBrowse link 14 45,062,662 45,065,014 RGD:1624291
RGD:1600115
positive regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1600115
RGD:1624291
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:1624291
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link 14 106,008,086 106,062,566 RGD:1624291
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:13792537
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Wdfy1 WD repeat and FYVE domain containing 1 JBrowse link 9 85,477,070 85,528,885 RGD:1624291
positive regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:1624291
RGD:1600115
G Ltf lactotransferrin JBrowse link 8 119,290,416 119,313,261 RGD:1624291
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 JBrowse link 3 80,004,130 80,014,197 RGD:1624291
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link 14 106,008,086 106,062,566 RGD:1624291
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:13792537
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:1624291
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Wdfy1 WD repeat and FYVE domain containing 1 JBrowse link 9 85,477,070 85,528,885 RGD:1624291
positive regulation of toll-like receptor 7 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddx3x DEAD-box helicase 3, X-linked JBrowse link X 10,400,363 10,414,010 RGD:1624291
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:13792537
G Rsad2 radical S-adenosyl methionine domain containing 2 JBrowse link 6 45,655,947 45,669,083 RGD:1600115
RGD:1624291
G Treml4 triggering receptor expressed on myeloid cells-like 4 JBrowse link 9 14,668,691 14,707,122 RGD:1624291
RGD:13792537
positive regulation of toll-like receptor 8 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddx3x DEAD-box helicase 3, X-linked JBrowse link X 10,400,363 10,414,010 RGD:1624291
positive regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1600115
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:13792537
G Rsad2 radical S-adenosyl methionine domain containing 2 JBrowse link 6 45,655,947 45,669,083 RGD:1600115
RGD:1624291
G Rtn4 reticulon 4 JBrowse link 14 114,126,931 114,174,459 RGD:1600115
RGD:1624291
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
G Treml4 triggering receptor expressed on myeloid cells-like 4 JBrowse link 9 14,668,691 14,707,122 RGD:1624291
positive regulation of toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 JBrowse link 1 260,527,344 260,679,132 RGD:1624291
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1624291
G Tlr5 toll-like receptor 5 JBrowse link 13 101,364,784 101,385,764 RGD:1624291
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:1600115
RGD:1624291
G Irf7 interferon regulatory factor 7 JBrowse link 1 214,249,388 214,252,909 RGD:1624291
regulation of MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Irf7 interferon regulatory factor 7 JBrowse link 1 214,249,388 214,252,909 RGD:1624291
regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:1624291
regulation of RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nop53 NOP53 ribosome biogenesis factor JBrowse link 1 77,836,522 77,843,991 RGD:1624291
regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flot2 flotillin 2 JBrowse link 10 65,304,901 65,329,332 RGD:1624291
regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 JBrowse link 16 2,560,103 2,602,035 RGD:1624291
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 JBrowse link 7 26,256,179 26,306,128 RGD:1624291
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:1624291
regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
regulation of toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:1624291
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:1624291
RGD:1600115
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link 14 3,058,035 3,073,332 RGD:1624291
G Mfhas1 malignant fibrous histiocytoma amplified sequence 1 JBrowse link 16 60,120,457 60,208,550 RGD:1624291
RIG-I signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clpb caseinolytic mitochondrial matrix peptidase chaperone subunit B JBrowse link 1 166,739,372 166,866,095 RGD:1624291
G Ddx58 DEXD/H-box helicase 58 JBrowse link 5 56,486,584 56,536,898 RGD:1624291
G Lsm14a LSM14A mRNA processing body assembly factor JBrowse link 1 90,200,866 90,246,292 RGD:1624291
G Mavs mitochondrial antiviral signaling protein JBrowse link 3 123,776,147 123,790,572 RGD:1624291
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:1624291
G Phb2 prohibitin 2 JBrowse link 4 157,230,769 157,235,375 RGD:1624291
G Rnf135 ring finger protein 135 JBrowse link 10 67,531,989 67,551,237 RGD:1600115
RGD:1624291
G Trim25 tripartite motif-containing 25 JBrowse link 10 76,343,847 76,362,159 RGD:1624291
TIRAP-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
toll-like receptor 1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tlr1 toll-like receptor 1 JBrowse link 14 45,062,662 45,065,014 RGD:1600115
toll-like receptor 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
RGD:13792537
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 JBrowse link 1 260,527,344 260,679,132 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1600115
G Tnip2 TNFAIP3 interacting protein 2 JBrowse link 14 81,487,934 81,505,889 RGD:1624291
RGD:13792537
toll-like receptor 3 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:1624291
G Colec12 collectin sub-family member 12 JBrowse link 18 867,048 1,054,047 RGD:1624291
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:10054077
G LOC103694380 tumor necrosis factor-like JBrowse link 20 4,855,792 4,858,447 RGD:10054077
G Rftn1 raftlin lipid raft linker 1 JBrowse link 9 12,740,885 12,942,358 RGD:1624291
G Scara3 scavenger receptor class A, member 3 JBrowse link 15 42,605,505 42,638,409 RGD:1624291
G Scimp SLP adaptor and CSK interacting membrane protein JBrowse link 10 57,415,429 57,436,412 RGD:1624291
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1600115
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:10054077
G Tnip2 TNFAIP3 interacting protein 2 JBrowse link 14 81,487,934 81,505,889 RGD:1624291
RGD:13792537
G Unc93b1 unc-93 homolog B1, TLR signaling regulator JBrowse link 1 219,172,987 219,183,941 RGD:1624291
RGD:13792537
toll-like receptor 4 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:1624291
RGD:13792537
RGD:1600115
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
RGD:13792537
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Ly96 lymphocyte antigen 96 JBrowse link 5 1,972,212 1,989,448 RGD:1624291
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1624291
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:1624291
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:1600115
RGD:1624291
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 JBrowse link 1 260,527,344 260,679,132 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G S100a14 S100 calcium binding protein A14 JBrowse link 2 189,913,433 189,919,947 RGD:1624291
G Scimp SLP adaptor and CSK interacting membrane protein JBrowse link 10 57,415,429 57,436,412 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1600115
RGD:1624291
G Tnip3 TNFAIP3 interacting protein 3 JBrowse link 4 96,386,207 96,490,517 RGD:1624291
G Tril TLR4 interactor with leucine-rich repeats JBrowse link 4 83,967,695 83,972,540 RGD:1624291
RGD:13792537
toll-like receptor 5 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Tlr5 toll-like receptor 5 JBrowse link 13 101,364,784 101,385,764 RGD:1600115
toll-like receptor 6 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1600115
toll-like receptor 7 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 JBrowse link 1 260,527,344 260,679,132 RGD:1624291
G Scimp SLP adaptor and CSK interacting membrane protein JBrowse link 10 57,415,429 57,436,412 RGD:1624291
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:1624291
RGD:13792537
G Unc93b1 unc-93 homolog B1, TLR signaling regulator JBrowse link 1 219,172,987 219,183,941 RGD:1624291
RGD:13792537
toll-like receptor 8 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:1624291
toll-like receptor 9 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Epg5 ectopic P-granules autophagy protein 5 homolog JBrowse link 18 74,299,965 74,397,115 RGD:1624291
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:1600115
RGD:1624291
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 JBrowse link 1 260,527,344 260,679,132 RGD:1624291
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1600115
G Tnip2 TNFAIP3 interacting protein 2 JBrowse link 14 81,487,934 81,505,889 RGD:1624291
G Unc93b1 unc-93 homolog B1, TLR signaling regulator JBrowse link 1 219,172,987 219,183,941 RGD:1624291
RGD:13792537
toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07039446.2 RGD:1600115
G Bcl10 BCL10, immune signaling adaptor JBrowse link 2 251,805,392 251,814,957 RGD:1624291
G Cd180 CD180 molecule JBrowse link 2 32,820,275 32,833,223 RGD:1600115
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:1624291
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:9068941
G Lrrc19 leucine rich repeat containing 19 JBrowse link 5 113,614,164 113,626,834 RGD:1624291
G Mapkapk2 MAPK activated protein kinase 2 JBrowse link 13 47,785,157 47,871,684 RGD:1624291
RGD:13792537
G Mapkapk3 MAPK activated protein kinase 3 JBrowse link 8 116,012,126 116,046,012 RGD:1624291
RGD:13792537
RGD:1600115
G Rps6ka3 ribosomal protein S6 kinase A3 JBrowse link X 37,469,736 37,576,055 RGD:1624291
G Tlr1 toll-like receptor 1 JBrowse link 14 45,062,662 45,065,014 RGD:1643119
RGD:13792537
G Tlr11 toll-like receptor 11 JBrowse link 15 27,177,900 27,182,339 RGD:13792537
G Tlr12 toll-like receptor 12 JBrowse link 5 146,791,705 146,795,919 RGD:13792537
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1643119
RGD:13792537
RGD:5684896
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1643119
RGD:13792537
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1643119
RGD:13792537
G Tlr5 toll-like receptor 5 JBrowse link 13 101,364,784 101,385,764 RGD:13792537
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1643119
RGD:13792537
RGD:5684896
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:1643119
RGD:13792537
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:1643119
RGD:13792537
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1643119
RGD:13792537
G Traf3 Tnf receptor-associated factor 3 JBrowse link 6 135,610,698 135,720,247 RGD:1624291
G Unc93b1 unc-93 homolog B1, TLR signaling regulator JBrowse link 1 219,172,987 219,183,941 RGD:1624291
toll-like receptor TLR1:TLR2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Scimp SLP adaptor and CSK interacting membrane protein JBrowse link 10 57,415,429 57,436,412 RGD:1624291
TRAM-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:1624291
RGD:1600115
G Rab11fip2 RAB11 family interacting protein 2 JBrowse link 1 281,065,346 281,101,163 RGD:1624291
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:1624291
TRIF-dependent toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd300lf Cd300 molecule-like family member F JBrowse link 10 103,669,781 103,690,584 RGD:1624291
RGD:1600115
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:13792537
G Irf3 interferon regulatory factor 3 JBrowse link 1 100,992,244 100,997,202 RGD:1624291
G Ticam1 toll-like receptor adaptor molecule 1 JBrowse link 9 10,780,185 10,790,280 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1600115
RGD:1624291
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    signaling 7553
      signal transduction 6968
        pattern recognition receptor signaling pathway 155
          PAMP-triggered immunity signalling pathway 0
          cell surface pattern recognition receptor signaling pathway 4
          cytoplasmic pattern recognition receptor signaling pathway + 48
          intracellular endosomal pattern recognition receptor signaling pathway 0
          positive regulation of pattern recognition receptor signaling pathway + 41
          regulation of pattern recognition receptor signaling pathway + 90
          toll-like receptor signaling pathway + 107
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            pattern recognition receptor signaling pathway 155
              PAMP-triggered immunity signalling pathway 0
              cell surface pattern recognition receptor signaling pathway 4
              cytoplasmic pattern recognition receptor signaling pathway + 48
              intracellular endosomal pattern recognition receptor signaling pathway 0
              positive regulation of pattern recognition receptor signaling pathway + 41
              regulation of pattern recognition receptor signaling pathway + 90
              toll-like receptor signaling pathway + 107
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.