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ONTOLOGY REPORT - ANNOTATIONS


Term:lymphocyte activation involved in immune response
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Accession:GO:0002285 term browser browse the term
Definition:A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
Synonyms:related_synonym: lymphocyte activation during immune response


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B cell activation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GPR183 G protein-coupled receptor 183 JBrowse link 22 49,332,665 49,347,721 RGD:13508589
G IFNB1 interferon beta 1 JBrowse link 11 40,668,295 40,668,855 RGD:13508589
B cell proliferation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 9 53,118,462 53,262,092 RGD:13508589
G CD180 CD180 molecule JBrowse link 2 52,644,357 52,660,830 RGD:13508589
G CD19 CD19 molecule JBrowse link 6 18,419,092 18,425,524 RGD:13508589
G GAPT GRB2 binding adaptor protein, transmembrane JBrowse link 2 45,383,244 45,402,649 RGD:13508589
G PLCL2 phospholipase C like 2 JBrowse link 23 25,814,392 25,999,666 RGD:13508589
G TLR4 toll like receptor 4 JBrowse link 11 71,356,390 71,367,166 RGD:13508589
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EOMES eomesodermin JBrowse link 23 16,476,498 16,512,406 RGD:13508589
cytotoxic T cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RAB27A RAB27A, member RAS oncogene family JBrowse link 30 20,633,576 20,706,240 RGD:13508589
follicular B cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PLCG2 phospholipase C gamma 2 JBrowse link 5 70,054,683 70,233,459 RGD:13508589
germinal center B cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CDH17 cadherin 17 JBrowse link 29 38,918,098 38,980,709 RGD:13508589
G ITFG2 integrin alpha FG-GAP repeat containing 2 JBrowse link 27 41,933,741 41,944,464 RGD:13508589
isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 9 40,869,778 40,917,976 RGD:13508589
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 8 48,537,036 48,561,154 RGD:13508589
G CD40LG CD40 ligand JBrowse link X 107,001,421 107,023,007 RGD:13508589
G EXO1 exonuclease 1 JBrowse link 7 33,237,124 33,268,835 RGD:13508589
G EXOSC3 exosome component 3 JBrowse link 11 54,072,993 54,079,024 RGD:13508589
G LIG4 DNA ligase 4 JBrowse link 22 56,980,333 56,987,636 RGD:13508589
G MLH1 mutL homolog 1 JBrowse link 23 6,889,108 6,938,117 RGD:13508589
G MSH2 mutS homolog 2 JBrowse link 10 49,517,448 49,594,001 RGD:13508589
G MSH6 mutS homolog 6 JBrowse link 10 49,825,330 49,838,036 RGD:13508589
G NBN nibrin JBrowse link 29 35,416,093 35,477,569 RGD:13508589
G SWAP70 switching B cell complex subunit SWAP70 JBrowse link 21 32,910,547 32,985,617 RGD:13508589
isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HSPD1 heat shock protein family D (Hsp60) member 1 JBrowse link 37 7,010,421 7,025,912 RGD:13508589
marginal zone B cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CDH17 cadherin 17 JBrowse link 29 38,918,098 38,980,709 RGD:13508589
G DLL1 delta like canonical Notch ligand 1 JBrowse link 12 72,265,078 72,272,347 RGD:13508589
G LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase JBrowse link 6 14,631,638 14,640,147 RGD:13508589
G MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase JBrowse link 10 27,082,616 27,098,994 RGD:13508589
G NOTCH2 notch receptor 2 JBrowse link 17 56,854,825 57,020,157 RGD:13508589
G PTK2B protein tyrosine kinase 2 beta JBrowse link 25 30,137,546 30,264,221 RGD:13508589
mature B cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GPR183 G protein-coupled receptor 183 JBrowse link 22 49,332,665 49,347,721 RGD:13508589
memory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TSC1 TSC complex subunit 1 JBrowse link 9 51,409,307 51,459,546 RGD:13508589
natural killer cell activation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IFNA5 interferon, alpha 5 JBrowse link 11 40,726,568 40,727,131 RGD:13508589
G IFNA7 interferon, alpha 7 JBrowse link 11 40,862,587 40,863,150 RGD:13508589
G IFNK interferon kappa JBrowse link 11 45,641,627 45,642,256 RGD:13508589
G LOC100685213 interferon alpha-1/2 JBrowse link 11 40,816,731 40,817,513 RGD:13508589
G LOC100687928 interferon alpha-1/2 JBrowse link 11 40,749,643 40,750,398 RGD:13508589
G LOC100688084 interferon alpha-1/2 JBrowse link 11 40,765,515 40,766,521 RGD:13508589
natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CORO1A coronin 1A JBrowse link 6 18,161,850 18,167,915 RGD:13508589
G RAB27A RAB27A, member RAS oncogene family JBrowse link 30 20,633,576 20,706,240 RGD:13508589
G UNC13D unc-13 homolog D JBrowse link 9 4,753,300 4,766,751 RGD:13508589
negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARP3 poly(ADP-ribose) polymerase family member 3 JBrowse link 20 37,767,336 37,774,269 RGD:13508589
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G THOC1 THO complex 1 JBrowse link 7 67,082,100 67,136,592 RGD:13508589
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL6 BCL6 transcription repressor JBrowse link 34 20,112,302 20,135,705 RGD:13508589
negative regulation of memory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FGL2 fibrinogen like 2 JBrowse link 18 17,328,794 17,335,429 RGD:13508589
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PGLYRP1 peptidoglycan recognition protein 1 JBrowse link 1 109,614,404 109,618,242 RGD:13508589
G PGLYRP2 peptidoglycan recognition protein 2 JBrowse link 20 46,724,906 46,730,227 RGD:13508589
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HAVCR2 hepatitis A virus cellular receptor 2 JBrowse link 4 53,018,990 53,032,035 RGD:13508589
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL2 interleukin 2 JBrowse link 19 17,750,780 17,756,394 RGD:13508589
G IL4 interleukin 4 JBrowse link 11 20,972,693 20,981,539 RGD:13508589
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 7 25,265,836 25,312,417 RGD:13508589
G SMAD7 SMAD family member 7 JBrowse link 7 79,706,485 79,734,673 RGD:13508589
G ZBTB7B zinc finger and BTB domain containing 7B JBrowse link 7 42,468,376 42,482,219 RGD:13508589
G ZC3H12A zinc finger CCCH-type containing 12A JBrowse link 15 4,972,369 4,984,218 RGD:13508589
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TBX21 T-box transcription factor 21 JBrowse link 9 24,077,752 24,086,560 RGD:13508589
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANXA1 annexin A1 JBrowse link 1 84,744,159 84,763,011 RGD:13508589
G BCL6 BCL6 transcription repressor JBrowse link 34 20,112,302 20,135,705 RGD:13508589
G HLX H2.0 like homeobox JBrowse link 38 15,538,744 15,543,686 RGD:13508589
G LOC111089966 zinc finger protein 271 JBrowse link 7 54,714,912 54,727,638 RGD:13508589
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 10 48,916,446 48,977,183 RGD:13508589
plasma cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NKX2-3 NK2 homeobox 3 JBrowse link 28 12,466,319 12,469,467 RGD:13508589
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IFNG interferon gamma JBrowse link 10 10,406,866 10,411,698 RGD:13508589
positive regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EXOSC3 exosome component 3 JBrowse link 11 54,072,993 54,079,024 RGD:13508589
G HMCES 5-hydroxymethylcytosine binding, ES cell specific JBrowse link 20 2,808,687 2,831,123 RGD:13508589
G KMT5B lysine methyltransferase 5B JBrowse link 18 49,655,783 49,691,899 RGD:13508589
G KMT5C lysine methyltransferase 5C JBrowse link 1 102,334,687 102,342,090 RGD:13508589
G MAD2L2 mitotic arrest deficient 2 like 2 JBrowse link 2 84,539,724 84,549,402 RGD:13508589
G RIF1 replication timing regulatory factor 1 JBrowse link 19 52,661,278 52,711,969 RGD:13508589
G SHLD1 shieldin complex subunit 1 JBrowse link 24 15,957,863 16,037,336 RGD:13508589
G TFRC transferrin receptor JBrowse link 33 29,206,024 29,237,221 RGD:13508589
G TP53BP1 tumor protein p53 binding protein 1 JBrowse link 30 10,263,650 10,362,646 RGD:13508589
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B9D2 B9 domain containing 2 JBrowse link 1 112,621,832 112,627,726 RGD:13508589
G MLH1 mutL homolog 1 JBrowse link 23 6,889,108 6,938,117 RGD:13508589
G MSH2 mutS homolog 2 JBrowse link 10 49,517,448 49,594,001 RGD:13508589
G NSD2 nuclear receptor binding SET domain protein 2 JBrowse link 3 62,164,888 62,228,006 RGD:13508589
G TGFB1 transforming growth factor beta 1 JBrowse link 1 112,629,476 112,643,885 RGD:13508589
G TNFSF13 TNF superfamily member 13 JBrowse link 5 32,482,723 32,484,790 RGD:13508589
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL4 interleukin 4 JBrowse link 11 20,972,693 20,981,539 RGD:13508589
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 9 40,869,778 40,917,976 RGD:13508589
G CD40 CD40 molecule JBrowse link 24 33,352,992 33,383,488 RGD:13508589
G IL2 interleukin 2 JBrowse link 19 17,750,780 17,756,394 RGD:13508589
G IL4 interleukin 4 JBrowse link 11 20,972,693 20,981,539 RGD:13508589
G MLH1 mutL homolog 1 JBrowse link 23 6,889,108 6,938,117 RGD:13508589
G MSH2 mutS homolog 2 JBrowse link 10 49,517,448 49,594,001 RGD:13508589
G PAXIP1 PAX interacting protein 1 JBrowse link 16 18,066,289 18,116,007 RGD:13508589
G TBX21 T-box transcription factor 21 JBrowse link 9 24,077,752 24,086,560 RGD:13508589
positive regulation of memory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL23A interleukin 23 subunit alpha JBrowse link 10 635,384 640,715 RGD:13508589
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LAMP1 lysosomal associated membrane protein 1 JBrowse link 22 60,678,116 60,695,619 RGD:13508589
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD81 CD81 molecule JBrowse link 18 46,466,484 46,474,236 RGD:13508589
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANXA1 annexin A1 JBrowse link 1 84,744,159 84,763,011 RGD:13508589
G HLX H2.0 like homeobox JBrowse link 38 15,538,744 15,543,686 RGD:13508589
G RIPK2 receptor interacting serine/threonine kinase 2 JBrowse link 29 35,283,209 35,311,608 RGD:13508589
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 10 48,916,446 48,977,183 RGD:13508589
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MALT1 MALT1 paracaspase JBrowse link 1 17,351,458 17,412,591 RGD:13508589
G NFKBID NFKB inhibitor delta JBrowse link 1 116,763,371 116,770,683 RGD:13508589
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 8 251,776 313,290 RGD:13508589
G TYROBP transmembrane immune signaling adaptor TYROBP JBrowse link 1 116,757,271 116,760,453 RGD:13508589
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL23A interleukin 23 subunit alpha JBrowse link 10 635,384 640,715 RGD:13508589
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL18 interleukin 18 JBrowse link 5 20,972,742 20,995,327 RGD:13508589
G NLRP3 NLR family pyrin domain containing 3 JBrowse link 8 251,776 313,290 RGD:13508589
G PRKCZ protein kinase C zeta JBrowse link 5 57,012,020 57,113,346 RGD:13508589
G RARA retinoic acid receptor alpha JBrowse link 9 22,254,803 22,298,614 RGD:13508589
positive regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SHB SH2 domain containing adaptor protein B JBrowse link 11 54,189,580 54,329,004 RGD:13508589
regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APLF aprataxin and PNKP like factor JBrowse link 10 67,454,500 67,522,659 RGD:13508589
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor JBrowse link 9 42,859,154 42,896,044 RGD:13508589
regulation of memory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL6 BCL6 transcription repressor JBrowse link 34 20,112,302 20,135,705 RGD:13508589
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ZNF683 zinc finger protein 683 JBrowse link 2 73,656,842 73,667,621 RGD:13508589
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL27 interleukin 27 JBrowse link 6 18,243,988 18,248,369 RGD:13508589
T cell activation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD74 CD74 molecule JBrowse link 4 58,689,745 58,698,421 RGD:13508589
G F2RL1 F2R like trypsin receptor 1 JBrowse link 3 29,801,119 29,810,006 RGD:13508589
G IFNA5 interferon, alpha 5 JBrowse link 11 40,726,568 40,727,131 RGD:13508589
G IFNA7 interferon, alpha 7 JBrowse link 11 40,862,587 40,863,150 RGD:13508589
G IFNK interferon kappa JBrowse link 11 45,641,627 45,642,256 RGD:13508589
G LOC100685213 interferon alpha-1/2 JBrowse link 11 40,816,731 40,817,513 RGD:13508589
G LOC100687928 interferon alpha-1/2 JBrowse link 11 40,749,643 40,750,398 RGD:13508589
G LOC100688084 interferon alpha-1/2 JBrowse link 11 40,765,515 40,766,521 RGD:13508589
G PSEN1 presenilin 1 JBrowse link 8 46,495,551 46,569,532 RGD:13508589
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APBB1IP amyloid beta precursor protein binding family B member 1 interacting protein JBrowse link 2 7,151,443 7,250,412 RGD:13508589
G FGL2 fibrinogen like 2 JBrowse link 18 17,328,794 17,335,429 RGD:13508589
G ICAM1 intercellular adhesion molecule 1 JBrowse link 20 50,818,715 50,827,914 RGD:13508589
G ITGAL integrin subunit alpha L JBrowse link 6 17,605,611 17,645,134 RGD:13508589
T cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FCER1G Fc fragment of IgE receptor Ig JBrowse link 38 21,267,841 21,271,036 RGD:13508589
G LOC611538 C-type lectin domain family 4 member E JBrowse link 27 37,561,445 37,568,652 RGD:13508589
T cell proliferation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SLC11A1 solute carrier family 11 member 1 JBrowse link 37 25,039,203 25,047,461 RGD:13508589
G TNFSF18 TNF superfamily member 18 JBrowse link 7 25,983,064 25,994,605 RGD:13508589
G TP53 tumor protein p53 JBrowse link 5 32,561,406 32,565,149 RGD:13508589
T follicular helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GPR183 G protein-coupled receptor 183 JBrowse link 22 49,332,665 49,347,721 RGD:13508589
G RC3H1 ring finger and CCCH-type domains 1 JBrowse link 7 25,265,836 25,312,417 RGD:13508589
T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HMGB1 high mobility group box 1 JBrowse link 25 9,431,223 9,558,167 RGD:13508589
G IL18R1 interleukin 18 receptor 1 JBrowse link 10 40,614,336 40,653,300 RGD:13508589
G RELB RELB proto-oncogene, NF-kB subunit JBrowse link 1 110,436,677 110,466,709 RGD:13508589
G SEMA4A semaphorin 4A JBrowse link 7 41,670,814 41,695,349 RGD:13508589
G TMEM98 transmembrane protein 98 JBrowse link 9 40,130,421 40,144,120 RGD:13508589
T-helper 1 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MTOR mechanistic target of rapamycin kinase JBrowse link 2 84,818,893 84,939,283 RGD:13508589
T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RORA RAR related orphan receptor A JBrowse link 30 25,315,974 26,026,708 RGD:13508589
T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 8 48,537,036 48,561,154 RGD:13508589
G IL6 interleukin 6 JBrowse link 14 36,474,268 36,478,519 RGD:13508589
G IRF4 interferon regulatory factor 4 JBrowse link 35 760,367 782,314 RGD:13508589
G LY9 lymphocyte antigen 9 JBrowse link 38 21,522,898 21,554,652 RGD:13508589
G STAT3 signal transducer and activator of transcription 3 JBrowse link 9 20,539,660 20,614,631 RGD:13508589
T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BATF basic leucine zipper ATF-like transcription factor JBrowse link 8 48,537,036 48,561,154 RGD:13508589
G GATA3 GATA binding protein 3 JBrowse link 2 28,068,143 28,098,445 RGD:13508589
G IL4 interleukin 4 JBrowse link 11 20,972,693 20,981,539 RGD:13508589
T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL12B interleukin 12B JBrowse link 4 51,178,637 51,194,606 RGD:13508589
G PTGER4 prostaglandin E receptor 4 JBrowse link 4 68,663,362 68,676,241 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14453
    immune system process 1450
      leukocyte activation 495
        lymphocyte activation 417
          lymphocyte activation involved in immune response 114
            B cell activation involved in immune response + 51
            T cell activation involved in immune response + 63
            natural killer cell activation involved in immune response + 13
Path 2
Term Annotations click to browse term
  biological_process 14453
    cellular process 13629
      cell activation 565
        cell activation involved in immune response 152
          leukocyte activation involved in immune response 149
            lymphocyte activation involved in immune response 114
              B cell activation involved in immune response + 51
              T cell activation involved in immune response + 63
              natural killer cell activation involved in immune response + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.