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ONTOLOGY REPORT - ANNOTATIONS


Term:CD8-positive, alpha-beta intraepithelial T cell differentiation
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Accession:GO:0002300 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation
 related_synonym: CD8-positive, alpha-beta intraepithelial T cell development


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CD8-positive, alpha-beta intraepithelial T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr18 G protein-coupled receptor 18 ISO MGI:MGI:5708707 (MGI:MGI:5629467|PMID:25348153) RGD PMID:25348153 MGI:MGI:5629467 NCBI chr15:108,323,157...108,326,907
Ensembl chr15:108,323,179...108,326,907
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    immune system process 2843
      leukocyte activation 1060
        lymphocyte activation 875
          T cell activation 524
            T cell differentiation 290
              alpha-beta T cell differentiation 124
                CD8-positive, alpha-beta T cell differentiation 18
                  CD8-positive, alpha-beta intraepithelial T cell differentiation 1
Path 2
Term Annotations click to browse term
  biological_process 20028
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            immune system development 1074
              hematopoietic or lymphoid organ development 1009
                hemopoiesis 957
                  leukocyte differentiation 598
                    lymphocyte differentiation 410
                      T cell differentiation 290
                        alpha-beta T cell differentiation 124
                          alpha-beta intraepithelial T cell differentiation 1
                            CD8-positive, alpha-beta intraepithelial T cell differentiation 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.