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ONTOLOGY REPORT - ANNOTATIONS


Term:B cell activation involved in immune response
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Accession:GO:0002312 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
Synonyms:related_synonym: B lymphocyte activation during immune response;   B-cell activation during immune response


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B cell activation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpr183 G protein-coupled receptor 183 JBrowse link 15 108,364,701 108,376,221 RGD:13792537
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:1624291
B cell proliferation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Cd180 CD180 molecule JBrowse link 2 32,820,275 32,833,223 RGD:1624291
RGD:13792537
G Cd19 CD19 molecule JBrowse link 1 197,815,422 197,822,123 RGD:1624291
G Gapt Grb2-binding adaptor protein, transmembrane JBrowse link 2 41,869,555 41,874,130 RGD:1624291
RGD:13792537
G Plcl2 phospholipase C-like 2 JBrowse link 9 1,782,536 1,984,654 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
follicular B cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:1624291
RGD:1600115
germinal center B cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ada adenosine deaminase JBrowse link 3 160,115,840 160,139,947 RGD:1624291
G Cdh17 cadherin 17 JBrowse link 5 25,354,187 25,443,675 RGD:1624291
G Itfg2 integrin alpha FG-GAP repeat containing 2 JBrowse link 4 161,730,643 161,744,281 RGD:1624291
isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aicda activation-induced cytidine deaminase JBrowse link 4 155,359,909 155,371,104 RGD:1624291
G Atad5 ATPase family, AAA domain containing 5 JBrowse link 10 67,427,042 67,475,825 RGD:1624291
G Batf basic leucine zipper ATF-like transcription factor JBrowse link 6 109,562,415 109,584,541 RGD:1600115
RGD:1624291
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:1600115
RGD:1624291
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:1624291
G Exo1 exonuclease 1 JBrowse link 13 93,936,989 93,962,749 RGD:1624291
G Exosc3 exosome component 3 JBrowse link 5 60,866,498 60,871,734 RGD:1624291
G Exosc6 exosome component 6 JBrowse link 19 43,190,879 43,193,164 RGD:1624291
G Lig4 DNA ligase 4 JBrowse link 16 85,331,771 85,339,496 RGD:1624291
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:1624291
RGD:1600115
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:1600115
RGD:1624291
G Msh6 mutS homolog 6 JBrowse link 6 11,644,565 11,662,389 RGD:1624291
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:1600115
RGD:1624291
G Rnf168 ring finger protein 168 JBrowse link 11 71,721,242 71,743,421 RGD:1624291
RGD:1600115
G Rnf8 ring finger protein 8 JBrowse link 20 8,285,380 8,309,858 RGD:1624291
RGD:1600115
G Swap70 switching B-cell complex subunit SWAP70 JBrowse link 1 174,862,683 174,924,101 RGD:1624291
G Ung uracil-DNA glycosylase JBrowse link 12 48,246,593 48,255,547 RGD:1624291
G Xrcc4 X-ray repair cross complementing 4 JBrowse link 2 18,674,496 18,927,463 RGD:1624291
isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr6 C-C motif chemokine receptor 6 JBrowse link 1 53,063,380 53,087,519 RGD:1624291
isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:1624291
marginal zone B cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G Cdh17 cadherin 17 JBrowse link 5 25,354,187 25,443,675 RGD:1624291
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:1600115
RGD:1624291
G Dock10 dedicator of cytokinesis 10 JBrowse link 9
9
86,424,638
86,312,470
86,571,854
86,423,054
RGD:1624291
G Dock11 dedicator of cytokinesis 11 JBrowse link X 122,507,169 122,690,463 RGD:1624291
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase JBrowse link 12 16,117,767 16,126,211 RGD:1624291
RGD:1600115
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase JBrowse link 7 119,978,981 119,996,824 RGD:1624291
G Notch2 notch receptor 2 JBrowse link 2 200,187,184 200,320,403 RGD:1624291
RGD:1600115
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1624291
RGD:1600115
mature B cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpr183 G protein-coupled receptor 183 JBrowse link 15 108,364,701 108,376,221 RGD:1624291
G LOC688282 hypothetical protein LOC688282 JBrowse link 10 106,800,040 106,810,153 RGD:1624291
negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Parp3 poly (ADP-ribose) polymerase family, member 3 JBrowse link 8 115,173,440 115,179,543 RGD:1624291
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Da2-19 uncharacterized LOC302729 JBrowse link X 48,196,789 48,213,506 RGD:1600115
G Thoc1 THO complex 1 JBrowse link 18 1,142,540 1,177,084 RGD:1624291
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link 18 31,574,759 31,625,286 RGD:1624291
plasma cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Itm2a integral membrane protein 2A JBrowse link X 78,490,872 78,496,814 RGD:1624291
G Lgals1 galectin 1 JBrowse link 7 120,153,184 120,156,290 RGD:1624291
G Lgals8 galectin 8 JBrowse link 17 66,487,451 66,515,316 RGD:1624291
G Nkx2-3 NK2 homeobox 3 JBrowse link 1 263,361,238 263,371,043 RGD:1624291
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
positive regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Exosc3 exosome component 3 JBrowse link 5 60,866,498 60,871,734 RGD:1624291
G Exosc6 exosome component 6 JBrowse link 19 43,190,879 43,193,164 RGD:1624291
G Hmces 5-hydroxymethylcytosine binding, ES cell specific JBrowse link 4 119,841,088 119,864,115 RGD:1600115
RGD:1624291
G Kmt5b lysine methyltransferase 5B JBrowse link 1 219,000,844 219,050,211 RGD:1600115
RGD:1624291
G Kmt5c lysine methyltransferase 5C JBrowse link 1 72,666,662 72,674,271 RGD:1600115
RGD:1624291
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link 5 164,943,183 164,956,255 RGD:1624291
G Paxip1 PAX interacting protein 1 JBrowse link 4 3,956,931 4,008,326 RGD:1624291
G Rif1 replication timing regulatory factor 1 JBrowse link 3 37,599,540 37,648,818 RGD:1624291
G Shld1 shieldin complex subunit 1 JBrowse link 3 125,318,682 125,396,705 RGD:1624291
RGD:13792537
G Shld2 shieldin complex subunit 2 JBrowse link 16 10,570,307 10,661,528 RGD:1624291
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:1624291
RGD:1600115
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link 3 113,160,030 113,259,701 RGD:1624291
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:1600115
RGD:1624291
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:1600115
RGD:1624291
G Nsd2 nuclear receptor binding SET domain protein 2 JBrowse link 14 82,119,210 82,196,501 RGD:1624291
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:1624291
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
G Tnfsf13 TNF superfamily member 13 JBrowse link 10 56,286,964 56,290,680 RGD:1624291
RGD:13792537
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clcf1 cardiotrophin-like cytokine factor 1 JBrowse link 1 219,468,866 219,472,445 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
RGD:13792537
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:1624291
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atad5 ATPase family, AAA domain containing 5 JBrowse link 10 67,427,042 67,475,825 RGD:1624291
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:1624291
RGD:1600115
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:1624291
RGD:13792537
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
RGD:13792537
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:1600115
RGD:1624291
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:1600115
RGD:1624291
G Pagr1 Paxip1-associated glutamate-rich protein 1 JBrowse link 1 198,448,790 198,451,078 RGD:1624291
G Paxip1 PAX interacting protein 1 JBrowse link 4 3,956,931 4,008,326 RGD:1624291
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:1624291
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
positive regulation of plasma cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
RGD:1600115
regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aplf aprataxin and PNKP like factor JBrowse link 4 119,514,822 119,568,764 RGD:1624291
G Mir181b1 microRNA 181b-1 JBrowse link 13 54,952,903 54,953,012 RGD:1624291
G Mir181b2 microRNA 181b-2 JBrowse link 3 23,151,455 23,151,542 RGD:1624291
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor JBrowse link 10 65,470,470 65,507,581 RGD:1624291
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
G Il27ra interleukin 27 receptor subunit alpha JBrowse link 19 25,151,835 25,163,995 RGD:1624291
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link 18 31,574,759 31,625,286 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19575
    immune system process 2692
      leukocyte activation 1006
        leukocyte activation involved in immune response 279
          lymphocyte activation involved in immune response 190
            B cell activation involved in immune response 82
              B cell proliferation involved in immune response 6
              isotype switching + 56
              mature B cell differentiation involved in immune response + 19
Path 2
Term Annotations click to browse term
  biological_process 19575
    cellular process 18359
      cell activation 1129
        cell activation involved in immune response 284
          leukocyte activation involved in immune response 279
            lymphocyte activation involved in immune response 190
              B cell activation involved in immune response 82
                B cell proliferation involved in immune response 6
                isotype switching + 56
                mature B cell differentiation involved in immune response + 19
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.