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ONTOLOGY REPORT - ANNOTATIONS


Term:germinal center B cell differentiation
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Accession:GO:0002314 term browser browse the term
Definition:The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: germinal center B lymphocyte differentiation
 related_synonym: germinal center B cell development


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germinal center B cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO MGI:MGI:1857117|MGI:MGI:2683027 (MGI:MGI:3619310|PMID:14607964) RGD PMID:14607964 MGI:MGI:3619310 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Cdh17 cadherin 17 ISO (MGI:MGI:3531365|PMID:15688343) RGD PMID:15688343 MGI:MGI:3531365 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Il21 interleukin 21 ISS
ISO
GO_REF:0000024
(MGI:MGI:5450752|PMID:23045607)
UniProt
RGD
PMID:23045607 GO_REF:0000024, MGI:MGI:5450752 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Il6 interleukin 6 ISS
ISO
GO_REF:0000024
(MGI:MGI:5450752|PMID:23045607)
UniProt
RGD
PMID:23045607 GO_REF:0000024, MGI:MGI:5450752 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 ISO MGI:MGI:4235940 (MGI:MGI:5547463|PMID:23997217) RGD PMID:23997217 MGI:MGI:5547463 NCBI chr 4:161,730,643...161,744,281
Ensembl chr 4:161,730,641...161,743,896
JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 ISO (MGI:MGI:5450752|PMID:23045607) RGD PMID:23045607 MGI:MGI:5450752 NCBI chr 8:55,603,968...55,631,448
Ensembl chr 8:55,603,968...55,631,446
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    immune system process 2843
      leukocyte activation 1060
        leukocyte activation involved in immune response 294
          lymphocyte activation involved in immune response 200
            B cell activation involved in immune response 88
              mature B cell differentiation involved in immune response 25
                germinal center B cell differentiation 6
Path 2
Term Annotations click to browse term
  biological_process 20028
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            animal organ development 4035
              hematopoietic or lymphoid organ development 1009
                hemopoiesis 957
                  leukocyte differentiation 598
                    lymphocyte differentiation 410
                      B cell differentiation 148
                        mature B cell differentiation 32
                          mature B cell differentiation involved in immune response 25
                            germinal center B cell differentiation 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.