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ONTOLOGY REPORT - ANNOTATIONS


Term:marginal zone B cell differentiation
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Accession:GO:0002315 term browser browse the term
Definition:The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: marginal zone B lymphocyte differentiation
 related_synonym: marginal zone B cell development


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marginal zone B cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl3 BCL3, transcription coactivator ISO MGI:MGI:1861796 (MGI:MGI:85481|PMID:9009202) RGD PMID:9009202 MGI:MGI:85481 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Cdh17 cadherin 17 ISO (MGI:MGI:3531365|PMID:15688343) RGD PMID:15688343 MGI:MGI:3531365 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Dll1 delta like canonical Notch ligand 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:3044313|PMID:15146182), (MGI:MGI:3838059|PMID:19217325)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:15146182, PMID:19217325 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3044313, MGI:MGI:3838059 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Dock10 dedicator of cytokinesis 10 ISO (MGI:MGI:5818419|PMID:25729399) RGD PMID:25729399 MGI:MGI:5818419 NCBI chr 9:86,424,638...86,571,854
NCBI chr 9:86,312,470...86,423,054
Ensembl chr 9:86,312,501...86,571,870
JBrowse link
G Dock11 dedicator of cytokinesis 11 ISO (MGI:MGI:5818419|PMID:25729399) RGD PMID:25729399 MGI:MGI:5818419 NCBI chr  X:122,507,169...122,690,463
Ensembl chr  X:122,507,374...122,690,465
JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISO
ISS
(MGI:MGI:3838059|PMID:19217325)
GO_REF:0000024
RGD
UniProt
PMID:19217325 GO_REF:0000024, MGI:MGI:3838059 NCBI chr12:16,117,767...16,126,211
Ensembl chr12:16,118,634...16,126,953
JBrowse link
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISO (MGI:MGI:3838059|PMID:19217325) RGD PMID:19217325 MGI:MGI:3838059 NCBI chr 7:119,978,981...119,996,824
Ensembl chr 7:119,978,983...119,996,824
JBrowse link
G Notch2 notch receptor 2 ISO
IEA
ISS
(MGI:MGI:3838059|PMID:19217325)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19217325 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3838059 NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO
ISS
(MGI:MGI:1860716|PMID:10881171)
GO_REF:0000024
RGD
UniProt
PMID:10881171 GO_REF:0000024, MGI:MGI:1860716 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    immune system process 2844
      leukocyte activation 1058
        leukocyte activation involved in immune response 294
          lymphocyte activation involved in immune response 200
            B cell activation involved in immune response 88
              mature B cell differentiation involved in immune response 25
                marginal zone B cell differentiation 9
Path 2
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            animal organ development 4035
              hematopoietic or lymphoid organ development 1008
                hemopoiesis 956
                  leukocyte differentiation 597
                    lymphocyte differentiation 409
                      B cell differentiation 148
                        mature B cell differentiation 32
                          mature B cell differentiation involved in immune response 25
                            marginal zone B cell differentiation 9
paths to the root

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